Results 341 to 350 of about 504,196 (405)

Inhibitors of cyclin-dependent kinase and cancer

Journal of Molecular Medicine, 1995
Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
Andrew S. Kraft, Joseph R. Biggs
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Cyclin-dependent kinase pathways as targets for cancer treatment.

Journal of Clinical Oncology, 2006
Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic and epigenetic events cause universal overactivity of the cell cycle cdks in human cancer, and their inhibition can lead to both
G. Shapiro
semanticscholar   +1 more source

Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology, 1996
The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function ...
openaire   +3 more sources

Designing Inhibitors of Cyclin-Dependent Kinases

Annual Review of Pharmacology and Toxicology, 2002
Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle   +2 more
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Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
Shreyans K. Jain, Sandip B. Bharate, Ram A. Vishwakarma   +2 more
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Quinazolines as cyclin dependent kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2001
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
Haiying Chen, Jie Liu, Jodi K. Muckelbauer, Steven P. Seitz, Pamela A. Benfield, Sarah Cox, John F. Boylan, Tricia L. Johnson, Chong-Hwan Chang, Catherine R. Burton, Robert H. Grafstrom, Angela Smallwood, Michael D. Boisclair, Thais M. Sielecki, George L. Trainor   +14 more
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Chemical inhibitors of cyclin-dependent kinases

Trends in Cell Biology, 1995
The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
openaire   +5 more sources

Identification of substrates for cyclin dependent kinases

Advances in Enzyme Regulation, 2010
Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes. From yeast to humans, cell cycle progression and cell division require the activation of a group of serine– threonine protein kinases called cyclin dependent kinases (CDKs) (Morgan, 1997), which initiate and coordinate these processes by orderly phosphorylation ...
Krupa Deshmukh, Andrei Pozniakovsky, Yoshimi Tanaka, Tim Hunt, Alessia Errico   +4 more
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Pharmacological inhibitors of cyclin-dependent kinases

Trends in Pharmacological Sciences, 2002
Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. Deregulation of CDKs in various diseases has stimulated an intensive search for selective pharmacological inhibitors of these kinases.
Marie Knockaert, Paul Greengard, Laurent Meijer   +2 more
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Cyclins, cyclin‐dependent kinases and differentiation

BioEssays, 1997
AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
Chun Y. Gao, Peggy S. Zelenka
openaire   +3 more sources