Results 71 to 80 of about 383,210 (284)
Proceedings of the National Academy of Sciences of the United States of America, 1995 The transforming growth factor beta s (TGF-beta s) are a group of multifunctional growth factors which inhibit cell cycle progression in many cell types.
M. Datto +5 more
semanticscholar +1 more source
Cyclin-dependent kinases in C. elegans.
Cell division, 2006 Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machinery has been identified, and a major challenge in coming years will be to understand the complex interplay between cell division and ...
openaire +4 more sources
An RB insensitive to CDK regulation
Molecular & Cellular Oncology, 2017 The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays ...
Manel Joaquin +2 more
doaj +1 more source
Overview of Current Type I/II Kinase Inhibitors [PDF]
arXiv, 2018 Research on kinase-targeting drugs has made great strides over the last 30 years and is attracting greater attention for the treatment of yet more kinase-related diseases. Currently, 42 kinase drugs have been approved by the FDA, most of which (39) are Type I/II inhibitors.
arxiv
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.
Journal of Clinical Investigation, 2012 Altered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains poorly understood at the molecular level.
Xiaoping Zhao +18 more
semanticscholar +1 more source
Inhibition of cyclin-dependent kinases by p21. [PDF]
Molecular Biology of the Cell, 1995 p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We have explored the interaction of p21 with the currently known Cdks. p21 effectively inhibits Cdk2, Cdk3, Cdk4, and Cdk6 kinases (Ki 0.5-15 nM) but is much less effective toward Cdc2/cyclin B (Ki approximately 400 nM) and Cdk5 ...
Chang Bai +9 more
openaire +3 more sources
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
Nature Structural &Molecular Biology, 2012 Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation and RNA quality control. Structural considerations suggested a requirement for initiation-factor eviction in elongation-factor engagement and pausing of ...
S. Larochelle +8 more
semanticscholar +1 more source
CDK12/CDK13: New Hope for Targeted Therapy of Human Malignant Tumors
Zhongliu Fangzhi YanjiuCell cycle turnover depends on cyclin-dependent kinase (CDKs). CDK is the protein kinase family that plays the key role in regulating cell cycle and gene transcription.
CHEN Kaixing, WU Zhouying, YU Lan
doaj +1 more source
Cyclin C: The Story of a Non-Cycling Cyclin
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek +8 more
doaj +1 more source
A three-state kinetic mechanism for scaffold mediated signal transduction [PDF]
, 2008 Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert numerous physical effects on signaling pathways. To study these effects, we consider a minimal, three-state kinetic model of scaffold mediated kinase activation.
arxiv +1 more source