Results 141 to 150 of about 109,030,997 (289)

Cyclin-dependent kinase 1 depolymerizes nuclear lamin filaments by disrupting the head-to-tail interaction of the lamin central rod domain. [PDF]

J Biol Chem, 2022
Jeong S, Ahn J, Jo I, Kang SM, Park BJ, Cho HS, Kim YH, Ha NC.   +7 more
europepmc   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Cyclin-Dependent Kinase Inhibitor 1 [PDF]

, 2020
openaire   +1 more source

MicroRNA-195-3p inhibits cyclin dependent kinase 1 to induce radiosensitivity in nasopharyngeal carcinoma. [PDF]

Bioengineered, 2021
Xie F, Xiao W, Tian Y, Lan Y, Zhang C, Bai L.   +5 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Cyclin-Dependent Kinases Regulatory Subunit 1 [PDF]

, 2020
openaire   +1 more source

Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling - a hypothesis on neuronal migration

, 2006
Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling - a hypothesis on neuronal ...
Li-Huei Tsai (203109), Benjamin Adam Samuels (16429428), Zhigang Xie (203103)   +2 more
core   +1 more source

A CDK-4EBP1 signaling axis drives HSV-1 replication and underscores a druggable pathway for potent antiviral intervention

mBio
Herpes simplex virus type 1 (HSV-1) poses a persistent public health challenge, particularly due to the emergence of drug-resistant strains and the limited efficacy of current monotherapies.
Krishnaraju Madavaraju, Tejabhiram Yadavalli, Sudhanshu Kumar Singh, Chandrashekhar D. Patil, Hemant Borase, Deepak Shukla   +5 more
doaj   +1 more source

MicroRNA-337-3p impedes breast cancer progression by targeting cyclin-dependent kinase 1. [PDF]

Oncol Lett, 2022
Kong S, Liu J, Zhang B, Lv F, Yu Y, Qin T.   +5 more
europepmc   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source