Results 1 to 10 of about 161,781 (188)

Cyclin Dependent Kinase 2 (CDK2) Inhibitors in Oncology Clinical Trials: A Review [PDF]

Journal of Immunotherapy and Precision Oncology
Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with various cancers, most commonly breast, ovarian, prostate, leukemia ...
Isabelle House, Mari Valore-Caplan, Elijah Maris, Gerald S. Falchook   +3 more
doaj   +2 more sources

COMPUTATIONAL STUDY OF THE INTERACTION BETWEEN INDENE PYRAZOLE AND CYCLIN DEPENDENT KINASE 2

Química Nova, 2017
Proteins have been traditionally out of reach of electronic structure methods. But with technological advances in the development of powerful computers and the need to extend the methods of computational chemistry to problems of biological interest, such
Juan Enrique Torres, Juan Pablo Toro, Javier Vergara, Rosa Baldiris, Ricardo Vivas Reyes   +4 more
doaj   +2 more sources

Cyclin-dependent kinase 2 protects podocytes from apoptosis. [PDF]

Sci Rep, 2016
AbstractLoss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of DN, downregulated CDK2 (cyclin-dependent kinase 2). LPS-treatment of mice also
Saurus P, Kuusela S, Dumont V, Lehtonen E, Fogarty CL, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Lehtonen S.   +10 more
europepmc   +7 more sources

Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2 [PDF]

The Journal of Neuroscience, 2008
Accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (Cdk5) activity is associated with apoptosis in various neurodegenerative disease models. Interestingly, recent studies suggest that Cdk5 may also favor neuronal survival.
Zelda H. Cheung, Ke Gong, Nancy Y. Ip
openalex   +6 more sources

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers. [PDF]

J Breast Cancer, 2020
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel is a cause of poor response in the patients. The aim of this study was to examine the role of protein phosphatase 1H (PPM1H) in paclitaxel resistance in breast cancer patients.To investigate the function of ...
Hur S, Kim JH, Yun J, Ju YW, Han JM, Heo W, Kim K, Jeong K, Lee HB, Han W, Noh DY, Kim JI, Moon HG.   +12 more
europepmc   +4 more sources

Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313. [PDF]

Acta Crystallogr F Struct Biol Commun, 2020
Talapati SR, Nataraj V, Pothuganti M, Gore S, Ramachandra M, Antony T, More SS, Krishnamurthy NR.   +7 more
europepmc   +3 more sources

Cyclin-dependent kinase 2 controls peripheral immune tolerance. [PDF]

J Immunol, 2012
Abstract Adaptive immunity requires signals from both the TCR and the costimulatory molecule CD28. These receptors activate multiple signaling pathways, including the cyclin-dependent kinase (CDK) cascade, and antigenic signals in the absence of costimulation result in a tolerant state that is enforced by the CDK inhibitory protein ...
Chunder N, Wang L, Chen C, Hancock WW, Wells AD.   +4 more
europepmc   +4 more sources

Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma [PDF]

Translational Oncology, 2016
Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear.
Jia Wang, Tong Yang, Gaofeng Xu, Hao Liu, Chunying Ren, Wanfu Xie, Maode Wang   +6 more
doaj   +2 more sources

Phosphorylations of Cyclin-dependent Kinase 2 Revisited Using Two-dimensional Gel Electrophoresis [PDF]

Journal of Biological Chemistry, 2003
To control the G1/S transition and the progression through the S phase, the activation of the cyclin-dependent kinase (CDK) 2 involves the binding of cyclin E then cyclin A, the activating Thr-160 phosphorylation within the T-loop by CDK-activating kinase (CAK), inhibitory phosphorylations within the ATP binding region at Tyr-15 and Thr-14 ...
Katia Coulonval, Laurence Bockstaele, Sabine Paternot, Pierre P. Roger   +3 more
openalex   +4 more sources

Foxp3 protein stability is regulated by cyclin-dependent kinase 2. [PDF]

J Biol Chem, 2013
Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and inflammatory disease. Expression of Foxp3 is necessary for the anti-inflammatory capacity of Treg, but whether Foxp3 activity is further subject to regulation by extracellular
Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD.   +4 more
europepmc   +4 more sources