Results 1 to 10 of about 684,636 (226)

Cyclin-dependent kinase 2 controls peripheral immune tolerance. [PDF]

J Immunol, 2012
Abstract Adaptive immunity requires signals from both the TCR and the costimulatory molecule CD28. These receptors activate multiple signaling pathways, including the cyclin-dependent kinase (CDK) cascade, and antigenic signals in the absence of costimulation result in a tolerant state that is enforced by the CDK inhibitory protein ...
Chunder N, Wang L, Chen C, Hancock WW, Wells AD.   +4 more
europepmc   +6 more sources

Role for cyclin-dependent kinase 2 in mitosis exit [PDF]

Current Biology, 2001
Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity [1]. Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B [2]. Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable [5]. At the end of mitosis, downregulation of cdk2-cyclin
Vincenzo D’Angiolella, Vincenzo Costanzo, Max E. Gottesman, Enrico V. Avvedimento, Jean Gautier, Domenico Grieco   +5 more
openalex   +6 more sources

Cyclin Dependent Kinase 2 (CDK2) Inhibitors in Oncology Clinical Trials: A Review [PDF]

Journal of Immunotherapy and Precision Oncology
Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with various cancers, most commonly breast, ovarian, prostate, leukemia ...
Isabelle House, Mari Valore-Caplan, Elijah Maris, Gerald S. Falchook   +3 more
doaj   +2 more sources

Cyclin-dependent Kinase 2 Nucleocytoplasmic Translocation Is Regulated by Extracellular Regulated Kinase [PDF]

Journal of Biological Chemistry, 2001
Activation of cyclin-dependent kinase 2 (CDK2)-cyclin E in the late G(1) phase of the cell cycle is important for transit into S phase. In Chinese hamster embryonic fibroblasts (IIC9) phosphatidylinositol 3-kinase and ERK regulate alpha-thrombin-induced G(1) transit by their effects on cyclin D1 protein accumulation (Phillips-Mason, P. J., Raben, D. M.,
Susan M. Keenan, Clifford J. Bellone, Joseph J. Baldassare   +2 more
openalex   +5 more sources

Molecular Motions of Human Cyclin-dependent Kinase 2 [PDF]

Journal of Biological Chemistry, 2005
We present a comprehensive description of the dynamic behavior of CDK2 in complex with cyclin A, arrived at by analysis of a total of 0.25 micros of solvated molecular dynamics trajectories and 42 deposited CDK2 structures, and refined using other protein simulation algorithms. The CDK2-cyclin A dimer is a dynamic complex of 6 subdomains.
C. Paul Barrett, M.E.M. Noble
openalex   +5 more sources

Cyclin-dependent kinase 2 protects podocytes from apoptosis. [PDF]

Sci Rep, 2016
AbstractLoss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of DN, downregulated CDK2 (cyclin-dependent kinase 2). LPS-treatment of mice also
Saurus P, Kuusela S, Dumont V, Lehtonen E, Fogarty CL, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Lehtonen S.   +10 more
europepmc   +8 more sources

Modulation of β-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2 [PDF]

Journal of Biological Chemistry, 2004
beta-Catenin functions as a downstream component of the Wnt/Wingless signal transduction pathway, and inappropriate control of cytosolic beta-catenin is a crucial step in the genesis of several human cancers. Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in
Chun Shik Park, Sung Il Kim, Mi Su Lee, Cho-ya Youn, Dae Joong Kim, Eek‐hoon Jho, Woo Keun Song   +6 more
openalex   +5 more sources

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers. [PDF]

J Breast Cancer, 2020
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel is a cause of poor response in the patients. The aim of this study was to examine the role of protein phosphatase 1H (PPM1H) in paclitaxel resistance in breast cancer patients.To investigate the function of ...
Hur S, Kim JH, Yun J, Ju YW, Han JM, Heo W, Kim K, Jeong K, Lee HB, Han W, Noh DY, Kim JI, Moon HG.   +12 more
europepmc   +5 more sources

Foxp3 protein stability is regulated by cyclin-dependent kinase 2. [PDF]

J Biol Chem, 2013
Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and inflammatory disease. Expression of Foxp3 is necessary for the anti-inflammatory capacity of Treg, but whether Foxp3 activity is further subject to regulation by extracellular
Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD.   +4 more
europepmc   +5 more sources

Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma [PDF]

Translational Oncology, 2016
Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear.
Jia Wang, Tong Yang, Gaofeng Xu, Hao Liu, Chunying Ren, Wanfu Xie, Maode Wang   +6 more
doaj   +2 more sources