Results 1 to 10 of about 152,744 (302)

Cyclin Dependent Kinase 2 (CDK2) Inhibitors in Oncology Clinical Trials: A Review [PDF]

Journal of Immunotherapy and Precision Oncology
Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with various cancers, most commonly breast, ovarian, prostate, leukemia ...
Isabelle House, Mari Valore-Caplan, Elijah Maris, Gerald S. Falchook   +3 more
doaj   +2 more sources

Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma [PDF]

Translational Oncology, 2016
Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear.
Jia Wang, Tong Yang, Gaofeng Xu, Hao Liu, Chunying Ren, Wanfu Xie, Maode Wang   +6 more
doaj   +2 more sources

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

ASSOCIATION OF RS2069502 CYCLIN-DEPENDENT KINASE 4 GENE WITH BREAST CANCER [PDF]

Euromediterranean Biomedical Journal, 2020
The goal of this project was to evaluate the association of candidate genetic variant rs2069502 of the CDK4 gene with breast cancer and the effect of variant genotypes on the serum concentration of CDK4 enzyme and consequently, on the occurrence of ...
Dalya Shakir Al-owaidi
doaj   +1 more source

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

PLoS ONE, 2023
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in ...
Anna McGriff, William J Placzek
doaj   +1 more source

Study of cytostatic and cytotoxic characteristics of modified peptide CDK4/6 inhibitors – functional analogs of p16INK4a (90-97)

Успехи молекулярной онкологии, 2021
Background. Application of mathematical modeling for search for biologically active molecules is currently a promising scientific approach. Application of numerical algorithms for optimization of peptide sequences and molecular dynamics allowed to obtain
V. K. Bozhenko, T. M. Kulinich, E. A. Kudinova, A. V. Ivanov, A. M. Shishkin, V. A. Solodkiy   +5 more
doaj   +1 more source

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Journal of Translational Medicine, 2021
Background Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu   +6 more
doaj   +1 more source

CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors

Biomolecules, 2022
In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro, Mathias Fagbemi, Michael Tellier, Justyna Zaborowska, Stephanie Barker, Marjorie Fournier, Shona Murphy   +6 more
doaj   +1 more source

Investigation of the effect of 5-Aza-2'-deoxycytidine in comparison to and in combination with trichostatin a on p16INK4a, p14ARF, p15INK4b gene expression, cell growth inhibition and apoptosis induction in colon cancer Caco-2 cell line

International Journal of Preventive Medicine, 2021
Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei, Fraidoon Kavoosi, Vahid Ghasemzadeh   +2 more
doaj   +1 more source

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific Reports, 2023
p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina   +8 more
doaj   +1 more source