Results 1 to 10 of about 8,638 (116)
Cyclin C: The Story of a Non-Cycling Cyclin [PDF]
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek +8 more
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Cyclin K and cyclin D1b are oncogenic in myeloma cells [PDF]
Molecular Cancer, 2010 Background Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two ...
Renoir Jack-Michel +8 more
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Mesenchymal stem cell derived exosome promotes the viability of ameloblast-like cells [PDF]
Nanomedicine Research Journal, 2023 Objective(s): To assess the effects of the exosome produced by mesenchymal stem cells (MSCs) on ameloblast-like cells' capacity to proliferate.Methods: The exosomes were isolated from the human BM-MSCs and characterized by TEM images and western blotting.
Bardia Mortezagholi +6 more
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Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin–cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
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Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
Life Science Alliance, 2021 Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1. Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry.
Helena Silva Cascales +8 more
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BMC Cancer, 2020 Background A. oxyphylla extract is known to possess a wide range of pharmacological activites. However, the molecular mechanism of A. oxyphylla and its bioactive compound nootkatone in colorectal cancer is unknown.
Eunsu Yoo +6 more
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Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Annals of Agricultural and Environmental Medicine, 2015 [b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska +5 more
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The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
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Folia Histochemica et Cytobiologica, 2012 Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic ...
Ana Alekseenko +6 more
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Living with or without cyclins and cyclin-dependent kinases [PDF]
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. Studies performed over more than a decade have supported the view that these holoenzymes are important, if not ...
Charles J, Sherr, James M, Roberts
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