DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]
, 2016 Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona +11 more
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Molecular Cancer, 2007 Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao John P
doaj +1 more source
Cyclin K and cyclin D1b are oncogenic in myeloma cells
Molecular Cancer, 2010 Background Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two ...
Renoir Jack-Michel +8 more
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Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6 [PDF]
Structure, 1999 Cyclin-dependent kinases (CDKs) have a central role in cell-cycle control and are activated by complex formation with positive regulatory proteins called cyclins and by phosphorylation. The overexpression and mutation of cyclins and CDKs has been associated with tumorigenesis and oncogenesis.
Schulze-Gahmen, Ursula +2 more
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Cyclin E Expression and Proliferation in Breast Cancer
Analytical Cellular Pathology, 1998 Cyclin E is a part of the cell cycle machinery and aberrantly expressed in several malignancies including breast cancer. Since cyclin E is cell cycle specifically expressed, we wanted to examine the relation between proliferation and expression of cyclin
Niels H. Nielsen +3 more
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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]
PLoS Biology, 2007 Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist +3 more
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A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]
, 2008 A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza +7 more
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Oncology Letters, 2014 Cell cycles, ordered series of events modulating cell growth and division, are tightly regulated by complexes containing cyclin-dependent kinases (CDKs) and cyclins. Cyclin O is a novel cyclin family protein which interacts with CDK2. However, the molecular effects of cyclin O on the activity of CDK2 have not been fully evaluated.
KIM, DO HYUNG +5 more
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Immunohistochemical analysis of cyclin A expression in Wilms tumor [PDF]
PeerJ, 2019 Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative ...
Sanja Radojević-Škodrić +9 more
doaj +2 more sources
eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]
, 2019 CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina +13 more
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