Results 21 to 30 of about 406,416 (358)
iScience, 2020 Summary: Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth.
Xian-Feng Wang +8 more
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Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K. Teixeira
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Reversal of terminal differentiation and control of DNA replication [PDF]
, 1993 DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina +2 more
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Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]
The EMBO Journal, 2018 AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia +12 more
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siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. [PDF]
PLoS ONE, 2010 Cyclin E is aberrantly expressed in many types of cancer including breast cancer. High levels of the full length as well as the low molecular weight isoforms of cyclin E are associated with poor prognosis of breast cancer patients.
Yulong Liang +5 more
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Arabidopsis D-Type Cyclin CYCD4;1 Is a Novel Cyclin Partner of B2-Type Cyclin-Dependent Kinase [PDF]
Plant Physiology, 2003 Abstract B-type cyclin-dependent kinases (CDKs) are unique to plants and are assumed to be involved in the control of the G2-to-M phase progression and mitotic events. However, little is known about their cyclin partners. In Arabidopsis, we isolated cDNA encoding the D-type cyclin CYCD4;1 by a yeast (Saccharomyces cerevisiae) two-hybrid ...
Atsushi, Kono +5 more
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Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
BMC Gastroenterology, 2004 Background Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.
Mahmoud Moustafa +6 more
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Determinants of human cyclin B1 association with mitotic chromosomes. [PDF]
PLoS ONE, 2013 Cyclin B1-CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several compartments of a mitotic cell ...
Kathleen L Pfaff, Randall W King
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Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]
Cell Cycle, 2007 The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
Brown, N. R. +5 more
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The cyclin D1b splice variant: an old oncogene learns new tricks
Cell Division, 2006 The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
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