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The double dealing of cyclin D1 [PDF]
Cell Cycle, 2019 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
Guergana Tchakarska, B. Sola
semanticscholar +9 more sources
Cyclin D1 expression in prostate carcinoma [PDF]
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
doaj +6 more sources
Molecular Cancer, 2007 Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao John P
doaj +2 more sources
PLoS ONE, 2017 The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein ...
Angela B Ortiz +5 more
doaj +2 more sources
Cyclin D1 expression in penile cancer. [PDF]
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE +11 more
europepmc +3 more sources
Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma [PDF]
The Journal of Clinical InvestigationOncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ).
Jithma P. Abeykoon +19 more
doaj +2 more sources
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [PDF]
eLifeIn healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.
Nelson García-Vázquez +12 more
doaj +2 more sources
Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh +7 more
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Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression [PDF]
Cancer Science, 2007 Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1‐ to S‐phase and for DNA replication.
Etsu, Tashiro +2 more
openaire +2 more sources
METTL16 promotes cell proliferation by up‐regulating cyclin D1 expression in gastric cancer
Journal of Cellular and Molecular Medicine, 2021 N6‐methyladenosine (m6A) is a well‐known modification of RNA. However, as a key m6A methyltransferase, METTL16 has not been thoroughly studied in gastric cancer (GC).
Xiao-Kun Wang +9 more
semanticscholar +1 more source