Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage. [PDF]
Aging, 2015 Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has ...
Casimiro, Mathew C +12 more
core +13 more sources
The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention [PDF]
Molecular Cancer, 2007 Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao John P
doaj +4 more sources
Cyclin d1 induces chromosomal instability. [PDF]
Oncotarget, 2012 We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly ...
Casimiro, Mathew C, Pestell, Richard
core +5 more sources
Cyclin D1 expression in prostate carcinoma [PDF]
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
doaj +4 more sources
The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer [PDF]
Chinese Journal of Lung Cancer, 2010 Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU +4 more
doaj +1 more source
Cyclin D1 expression in penile cancer. [PDF]
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE +11 more
europepmc +3 more sources
Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma [PDF]
The Journal of Clinical InvestigationOncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ).
Jithma P. Abeykoon +19 more
doaj +2 more sources
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [PDF]
eLifeIn healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.
Nelson García-Vázquez +12 more
doaj +2 more sources
Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh +7 more
doaj +1 more source
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
eLife, 2023 Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu +5 more
doaj +1 more source