Results 41 to 50 of about 299,961 (316)

Cyclin D1 immunohistochemical expression and somatic mutations in canine oral melanoma [PDF]

, 2019
Canine oral melanoma (COM) is the most frequent tumour with oral localization in dogs. Copy number gains and amplifications of CCND1, a gene coding for Cyclin D1, are the most frequent chromosomal aberrations described in human non-UV induced melanomas ...
Iussich, Selina, Ginevra Brocca, Silvia Ferro, Paloma J. de Andres, Chiara Dal Corso, Castagnaro, Massimo, Ferro, Silvia, Serena Ferraresso, Valentina Zappulli, Massimo Castagnaro, Zamboni, Clarissa, Dal Corso, Chiara, Cavicchioli, Laura, Sammarco, Alessandro, Clarissa Zamboni, Martínez De Merlo, Elena, Ferraresso, Serena, Zappulli, Valentina, Selina Iussich, Laura Cavicchioli, Andrés Gamazo, Paloma Jimena de, Brocca, Ginevra, Alessandro Sammarco, Elena M. Martìnez de Merlo   +23 more
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Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Popp, Oliver, Nalabothula, Narasimharao, Gil-Parrado, S., Jochum, M., Ghosh, M., Machleidt, W., Machleidt, Werner, Ghosh, Madhumita, Gil-Parrado, Shirley, Holak, Tad A., Joy, J., Joy, Joma, Holak, T. A., Jochum, Marianne, Popp, O., Nalabothula, N.   +15 more
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Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer

Current Issues in Molecular Biology, 2022
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha   +7 more
doaj   +1 more source

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms [PDF]

, 2018
Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored.
Beà, Sílvia, Colomer, Dolors, Albero, Robert, Enjuanes, A., Karube, Ken, Martin-Subero, Jose Ignacio, Jares, Pedro, Clot, Guillem, Demajo, Santiago, García, Noelia, Suárez-Cisneros, Helena, Pinyol, Magda, Capdevila, Cristina, Castellano, Giancarlo, Shimada, Mariko, Lopez-Guerra, Monica, Campo, Elías   +16 more
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Galectin-3 and cyclin D1 expression in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2011
Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin, Kowal Aneta, Piesiak Paweł, Kosacka Monika, Jankowska Renata   +4 more
doaj   +1 more source

The extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim, Dondu Nergiz, Canan Sadullahoglu, Zelal Akgunduz, Senay Yildirim, Selen Dogan, Cem Sezer   +6 more
doaj   +1 more source

Regulation of Cyclin D1 by Calpain Protease [PDF]

Journal of Biological Chemistry, 1997
Cyclin D1, a critical positive regulator of G1 progression, has been implicated in the pathogenesis of certain cancers. Regulation of cyclin D1 occurs at the transcriptional and posttranscriptional level. Here we present evidence that cyclin D1 levels are regulated at the posttranscriptional level by the Ca2+-activated protease calpain.
Y H, Choi, S J, Lee, P, Nguyen, J S, Jang, J, Lee, M L, Wu, E, Takano, M, Maki, P A, Henkart, J B, Trepel   +9 more
openaire   +2 more sources

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
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Cyclin d1 expression in odontogenic cysts [PDF]

Turkish Journal of Pathology, 2013
In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions.Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n ...
Nasim, Taghavi, Shirin, Modabbernia, Alireza, Akbarzadeh, Samad, Sajjadi   +3 more
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Prognostic Potential of Cyclin D1 Expression in Colorectal Cancer [PDF]

, 2023
Cyclin D1 is mainly known as an oncogenic driver in cancers, and the dysregulated cyclin D1/cyclin-dependent kinase (CDK) 4/6 axis is considered an attractive target for cancer therapy.
Lee-So Maeng, Sun-Young Jun, Jae Ho Byun, Nara Yoon, Jiyoung Kim, Maeng, Lee-So, Byun, Jae Ho, Yoon, Nara, Jun, Sun-Young, Kim, Jiyoung   +9 more
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