Results 41 to 50 of about 154,360 (283)
Cyclin D1 as a Useful Marker for the Differentiation of Ewing’s Sarcoma from Rhabdomyosarcoma
Middle East Journal of Cancer, 2020 Background: The main oncogenic action of CD99 and cyclin D1 biomarkers is referred to any mutation, amplification, and overexpression in cyclin D1 coding gene, altering cell cycle progression as the main mechanism observed in a variety of tumors.
Tina Shooshtarizadeh +2 more
doaj +1 more source
Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression [PDF]
, 2015 Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis1-3; dysregulation of this axis causes diabetes2,4. PGC-1α links insulin signaling to the expression of glucose and lipid metabolic genes5-7.
Camporez, Joao Paulo +13 more
core +1 more source
The Breast, 2006 Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues.
Pankaj G, Roy, Alastair M, Thompson
openaire +2 more sources
DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1. [PDF]
, 2015 Let-7 miRNAs act as tumour suppressors by directly binding to the 3\u27UTRs of downstream gene products. The regulatory role of let-7 in downstream gene expression has gained much interest in the cancer research community, as it controls multiple ...
Du, Ning +12 more
core +2 more sources
Cyclin D1 integrates G9a-mediated histone methylation. [PDF]
, 2019 Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.
Casimiro, Mathew C. +13 more
core +2 more sources
Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma
Acta Pharmaceutica Sinica BCyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu +10 more
doaj +1 more source
Diagnostic Pathology, 2013 Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases
Wang Yu +3 more
doaj +1 more source
E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Signal Transduction and Targeted Therapy, 2023 Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang +15 more
doaj +1 more source
Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Objective Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation and apoptosis of OA chondrocytes ...
Yi-Yue Chen +7 more
doaj +1 more source
Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes
Mutiara Medika, 2021 Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression.
Alfun Dhiya An +1 more
doaj +1 more source