Results 41 to 50 of about 250,304 (196)
E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Signal Transduction and Targeted Therapy, 2023 Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang +15 more
doaj +1 more source
An update on the implications of cyclin D1 in melanomas [PDF]
Pigment Cell & Melanoma Research, 2020 AbstractCyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation.
Lucia González‐Ruiz +5 more
openaire +3 more sources
Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes
Mutiara Medika, 2021 Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression.
Alfun Dhiya An +1 more
doaj +1 more source
, 2012 <p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L. +12 more
core +1 more source
Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India [PDF]
Archive of Oncology, 2018 Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. The percent-age of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced.
Ahmad Gatoo Manzoor, Mahmood Dar Ayaz
doaj
Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Objective Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation and apoptosis of OA chondrocytes ...
Yi-Yue Chen +7 more
doaj +1 more source
SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy
Cell Division, 2007 Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I +2 more
doaj +1 more source
Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation
, 2007 PURPOSE: To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention.
Betticher, Daniel C +9 more
core +1 more source
Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]
, 2011 A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed.
I. C. Baianu
core
Pharmaceuticals, 2012 The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins,
Kasturi Ranganna +3 more
doaj +1 more source