Results 61 to 70 of about 250,304 (196)
The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2010 Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU +4 more
doaj
Degradation strategy of cyclin D1 in cancer cells and the potential clinical application
Frontiers in Oncology, 2022 Cyclin D1 has been reported to be upregulated in several solid and hematologic tumors, promoting cancer progression. Thus, decreasing cyclin D1 by degradation could be a promising target strategy for cancer therapy.
Shuyi Chen, Ling Li
doaj +1 more source
Prognostic Potential of Cyclin D1 Expression in Colorectal Cancer
, 2023 Cyclin D1 is mainly known as an oncogenic driver in cancers, and the dysregulated cyclin D1/cyclin-dependent kinase (CDK) 4/6 axis is considered an attractive target for cancer therapy.
Lee-So Maeng +9 more
core +1 more source
Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels
BMC Cell Biology, 2006 Background The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of
Hitomi Masahiro +6 more
doaj +1 more source
Cyclin D1 Functions in Cell Migration [PDF]
Cell Cycle, 2006 Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer.
Zhiping, Li +3 more
openaire +2 more sources
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
Neural Development, 2009 Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon +3 more
doaj +1 more source
The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC
Analytical Cellular Pathology, 2022 Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its ...
Yan Shi +8 more
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Protein expression patterns of cell cycle regulators in operable breast cancer.
PLoS ONE, 2017 Background-aimTo evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes.MethodsCyclin E1, cyclin D1, p53, p21 and p27 were evaluated with ...
Flora Zagouri +23 more
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Cyclin D1 expression in penile cancer. [PDF]
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE +11 more
europepmc +3 more sources
The cyclin D1 expression in hepatocellular carcinoma.
, 2013 A- the immunoreactivity of cyclin D1 in HCC tumor; B- the cyclin D1 immunoreactivity in fibrolamellar carcinoma; scale bar 5 µm; C- Spearman's rank graph showing a negative correlation between the SHP and cyclin D1 immunoreactivity in G3 hepatocellular ...
Ewa Wilczek (88420) +7 more
core +1 more source