Results 61 to 70 of about 299,961 (316)

E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

Signal Transduction and Targeted Therapy, 2023
Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang, Xiangyu Gao, Yanyun He, Gengjia Chen, Fengxiang Lv, Peng Jiang, Yumei Li, Wenwen Li, Peng Jiang, Lin Wang, Jiafu Ji, Xinli Hu, Rui-Ping Xiao   +15 more
doaj   +1 more source

MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinoma

Cell Death and Disease, 2017
DNA replication is a central procedure of cell proliferation, whereas aberrant DNA replication is indicated to be a driving force of oncogenesis. Minichromosome maintenance complex component 7 (MCM7) plays an essential role in initiating DNA replication.
K. Qu, Zhi-xin Wang, H. Fan, Juan Li, Jie Liu, Pingping Li, Zheyong Liang, Hongli An, Yina Jiang, Q. Lin, Xiaoqun Dong, Peijun Liu, Chang Liu   +12 more
semanticscholar   +1 more source

Assembly, Activation, and Substrate Specificity of Cyclin D1/Cdk2 Complexes [PDF]

, 2016
Previous studies have shown conflicting data regarding cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes, and considering the widespread overexpression of cyclin D1 in cancer, it is important to fully understand their relevance.
Patrick E. Corsino (1956751), Thomas C. Rowe (1956754), Stephan C. Jahn (1956757), Bradley J. Davis (577823), Brian K. Law (577824), Mary E. Law (577821)   +5 more
core   +3 more sources

High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers

Breast Cancer Research and Treatment, 2017
PurposeCyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER ...
Cecilia Ahlin, C. Lundgren, Elin Embretsén-Varro, K. Jirström, C. Blomqvist, C. Blomqvist, M. Fjällskog   +6 more
semanticscholar   +1 more source

Aberrant Expression of Cyclin D1 in Cancer [PDF]

Signal Transduction Insights, 2015
Cyclin D1 binds and activates cyclin-dependent kinases 4/6 (Cdk4/6) to phosphorylate the retinoblastoma (RB) family proteins, relieving E2F/DPs from the negative restraint of RB proteins and histone deacetylases (HDACs). The cyclin D-Cdk4/6 complexes activate cyclin E/Cdk2 through titration of the Cdk inhibitors p21Cip1/p27Kip1.
Kazushi, Inoue, Elizabeth A, Fry
openaire   +2 more sources

Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India [PDF]

Archive of Oncology, 2018
Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. The percent-age of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced.
Ahmad Gatoo Manzoor, Mahmood Dar Ayaz
doaj  

Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Objective Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation and apoptosis of OA chondrocytes ...
Yi-Yue Chen, You Chen, Wan-Chuan Wang, Qi- Tang, Ren Wu, Wei-Hong Zhu, Ding Li, Le-Le Liao   +7 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Cyclin D1 and P27KIP1: The Gatekeepers of Dysplasia [PDF]

, 2018
There is increasing evidence suggesting that cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors (CDIs) either are themselves targets for genetic change in cancer or are disrupted secondarily by other oncogenic events. Cyclin
Bakr, Mahmoud, Guan, Simon, Love, Robert
core  

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

Cell Division, 2007
Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I, Barbash Olena, Diehl J Alan   +2 more
doaj   +1 more source