Results 71 to 80 of about 259,083 (282)

Regulation of cyclin D1 gene expression

Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. in different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas ...
Witzel II, Koh LF, Perkins ND
core   +5 more sources

Cyclin D1 Functions in Cell Migration [PDF]

Cell Cycle, 2006
Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer.
Zhiping, Li, Chenguang, Wang, George C, Prendergast, Richard G, Pestell   +3 more
openaire   +2 more sources

Transcriptional regulation by a DNA-associated form of cyclin D1. [PDF]

, 2005
Besides its function as a cell cycle regulator, cyclin D1 interacts with transcription factors to regulate gene activation. In this study, we show that cyclin D1 is recruited to the p21waf1 promoter by a STAT3-NcoA complex.
B. Barré, Olivier Coqueret, Sylvie Avril, O. Coqueret, Frédéric Bienvenu, Benjamin Barré, Bienvenu, Frédéric, Sandrine Giraud, Barré, Benjamin, Coqueret, Olivier, Avril, Sylvie, S. Giraud, F. Bienvenu, S. Avril, Giraud, Sandrine   +14 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells

Neural Development, 2009
Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon, Das Gaurav, Sicinski Piotr, Levine Edward M   +3 more
doaj   +1 more source

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Analytical Cellular Pathology, 2022
Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its ...
Yan Shi, Meng-Yan Li, Hui Wang, Chao Li, Wen-Ying Liu, Yong-Mei Gao, Bo Wang, Jia-Wei Song, Yu-Qing Ma   +8 more
doaj   +1 more source

v-Src oncogene induces Trop2 proteolytic activation via cyclin D1 [PDF]

, 2016
Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment of Src tyrosine kinase activity in approximately 90% of patients.
Gomella, Leonard G., Di Sante, Gabriele, Ju, Xiaoming, Di Rocco, Agnese, Andò, Sebastiano, Hawkins, Adam, Stoyanova, Tanya, Casimiro, Mathew C., Jiao, Xuanmao, Fatatis, Alessandro, Li, Zhiping, Lisanti, Michael P., Deng, Shengqiong, Zhan, Tingting, Ertel, Adam, Pestell, Richard G., Disante, Gabriele, Languino, Lucia R.   +17 more
core   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Protein expression patterns of cell cycle regulators in operable breast cancer.

PLoS ONE, 2017
Background-aimTo evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes.MethodsCyclin E1, cyclin D1, p53, p21 and p27 were evaluated with ...
Flora Zagouri, Vassiliki Kotoula, George Kouvatseas, Maria Sotiropoulou, Triantafyllia Koletsa, Theofani Gavressea, Christos Valavanis, Helen Trihia, Mattheos Bobos, Georgios Lazaridis, Angelos Koutras, George Pentheroudakis, Pantelis Skarlos, Dimitrios Bafaloukos, Niki Arnogiannaki, Sofia Chrisafi, Christos Christodoulou, Pavlos Papakostas, Gerasimos Aravantinos, Paris Kosmidis, Charisios Karanikiotis, George Zografos, Christos Papadimitriou, George Fountzilas   +23 more
doaj   +1 more source

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source