Results 71 to 80 of about 250,304 (196)

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2019
Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong   +7 more
doaj   +1 more source

Cyclin D1 and P27KIP1: The Gatekeepers of Dysplasia

, 2018
There is increasing evidence suggesting that cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors (CDIs) either are themselves targets for genetic change in cancer or are disrupted secondarily by other oncogenic events. Cyclin
Bakr, Mahmoud, Guan, Simon, Love, Robert
core  

Assembly, Activation, and Substrate Specificity of Cyclin D1/Cdk2 Complexes

, 2016
Previous studies have shown conflicting data regarding cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes, and considering the widespread overexpression of cyclin D1 in cancer, it is important to fully understand their relevance.
Patrick E. Corsino (1956751), Thomas C. Rowe (1956754), Stephan C. Jahn (1956757), Bradley J. Davis (577823), Brian K. Law (577824), Mary E. Law (577821)   +5 more
core   +2 more sources

Cyclin D₁ and Rb protein expression and their correlation with prognosis in patients with colon cancer

World Journal of Surgical Oncology, 2006
Background Cyclin D1 plays a major role as a potential contributor to the multistep process of oncogenesis; nevertheless its prognostic significance in colon cancer has already been examined in a few studies and needs to be further delineated. The aim of
Giaginis Costas, Vagianos Costas, Glinavou Andromahi, Vamvakas Panayiotis, Theocharis Stamos, Kouraklis Gregory, Sioka Crysoula   +6 more
doaj   +1 more source

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Oncogenesis
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W. Ashton, Zhiping Li, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, Tamas Lazar, Peter Tompa, Chenguang Wang, Zuoren Yu, Zhao Zhang, Kawthar Aldaaysi, Ratna Vadlamudi, Monica Mann, Emmanuel Skordalakes, Andrew Kossenkov, Yanming Du, Richard G. Pestell   +22 more
doaj   +1 more source

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

Haematologica, 2012
Background Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior.
Julia Slotta-Huspenina, Ina Koch, Laurence de Leval, Gisela Keller, Margit Klier, Karin Bink, Marcus Kremer, Mark Raffeld, Falko Fend, Leticia Quintanilla-Martinez   +9 more
doaj   +1 more source

Cyclin D1 expression in acute leukemia

Hematology, 2006
Disorders of the cell cycle regulatory machinery play a key role in the pathogenesis of cancer. Over expression of cyclin D1 protein has been reported in several solid tumors and certain lymphoid malignancies, but little is known about the involvement of cyclin D1 in acute leukemia.In this study, we analyzed the expression of cyclin D1 at protein level
Salah, Aref, M, Mabed, M, El-Sherbiny, T, Selim, A, Metwaly   +4 more
openaire   +2 more sources

Prolactin Promotes Mammary Pathogenesis Independently from Cyclin D1 [PDF]

, 2012
Epidemiological and experimental studies have revealed an important role for prolactin (PRL) in breast cancer. Cyclin D1 is a major downstream target of PRL in lobuloalveolar development during pregnancy and is amplified and/or overexpressed in many ...
Rugowski, Debra E., Kathleen A. O'Leary, Debra E. Rugowski, Linda A. Schuler, Jennifer M. Asher, Arendt, Lisa M., Schuler, Linda A., Lisa M. Arendt, O'Leary, Kathleen A., Asher, Jennifer M.   +9 more
core   +1 more source

Cyclin D1 is a NF-κB corepressor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
NF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-κB activity. We found that CD1 inhibits NF-κB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3.
Rubio, Maria Fernanda, Fernández Larrosa, Pablo Nicolás, Alvarado, Cecilia Viviana, Panelo, Laura Carolina, Ruiz Grecco, Marina, Colo, Georgina Pamela, Martínez Noël, Giselle María Astrid, Micenmacher, Sabrina Mariel, Costas, Monica Alejandra   +8 more
openaire   +3 more sources

The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian Cancers [PDF]

Cyclin-dependent kinases (CDK2, CDK4, CDK6), cyclin D1, cyclin E1 and phosphorylated retinoblastoma (pRB1) are key regulators of the G1/S cell cycle checkpoint and may influence platinum response in ovarian cancers.
Jennie N. Jeyapalan, Nigel P. Mongan, Sheha, Amera, Mashael Algethami, Shoqafi, Ahmed, Emad A. Rakha, Amera Sheha, Ayat Lashen, Ahmed Shoqafi, Madhusudan, Srinivasan, Srinivasan Madhusudan, Mongan, Nigel P., Rakha, Emad A., Jeyapalan, Jennie N., Lashen, Ayat, Algethami, Mashael, Shatha Alqahtani, Alqahtani, Shatha   +17 more
core   +1 more source