Results 91 to 100 of about 250,304 (196)
Activation of cyclin D1 expression by the ERK5 cascade
, 2003 Transcriptional activation of the cyclin D1 gene is a key step in cell proliferation. Accordingly, cyclin D1 overexpression is frequently an early step in neoplastic transformation, particularly in mammary epithelium.
Hipskind, R. A. +3 more
core +1 more source
Cyclin D1 Overexpression in Laryngeal Carcinomas.
Nippon Jibiinkoka Gakkai Kaiho, 1998 Overexpression of cyclin D1 has been found in a variety of malignancies and is suggested to be related to tumor progression. We immunohistochemically investigated the overexpression of cyclin D1 protein in 92 laryngeal carcinomas. Twenty-eight (30.4%) of the carcinoma specimens showed overexpression of cyclin D1.
Wang, Xue-feng +5 more
openaire +3 more sources
Caffeine, Cyclin D1 and Cell Proliferation
, 2012 Although well characterized as an inhibitor of DNA damage-induced checkpoint signaling, caffeine has also been reported to delay G1-S-phase cell cycle progression in various cell lines.
Alao, John Patrick,, John P. Alao
core +1 more source
CYPJ regulates the transcription of cyclin D1.
, 2015 (A) Effects of CYPJ overexpression on the expression of several cell cycle controllers. The mRNA levels of each gene were evaluated by quantitative real-time RT-PCR, and subsequently normalized by internal GAPDH ...
Jiahui Wang (746367) +10 more
core +1 more source
Mechanism of cyclin D1-dependent genomic instability and neoplastic transformation [PDF]
, 2011 Regulation of cyclin D1-dependent kinase activity is essential for cell cycle progression and DNA replication fidelity. Critically, impaired cyclin D1 phosphorylation and ubiquitin-mediated proteolysis following the G1/S transition drives neoplastic ...
Vaites, Laura Pontano +1 more
core
Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress
, 2006 The understanding of endothelial cell responses to oxidative stress may provide insights into aging mechanisms and into the pathogenesis of numerous cardiovascular diseases.
CAPOGROSSI MC +8 more
core +1 more source
The role of cyclin D1 in cancer
, 2004 Cyclin D1 protein levels are elevated by mitogenic and oncogenic signaling pathways as cyclin D1 protein is rate-limiting for G1-phase cell cycle progression in many cell types as well as over-expressed in 20--30% of human breast cancers and elevated in ...
Hulit, James
core
Lung IndiaBackground Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.
Neeraja Panakkal +3 more
doaj +1 more source
Cyclin D1 and Cdk4 Mediate Development of Neurologically Destructive Oligodendroglioma
, 2011 Although the molecular changes that characterize gliomas have been studied, the pathogenesis of tumor development remains unclear. p21 contributes to gliomagenesis by stabilizing cyclin D1–cdk4 kinase complexes, suggesting that cyclin D1 and cdk4 may ...
Yuhui Liu +4 more
core +1 more source
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
, 2013 Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma protein.
Muñoz Terol, Alberto +1 more
core +1 more source