Results 91 to 100 of about 259,083 (282)

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Cyclin D₁ and Rb protein expression and their correlation with prognosis in patients with colon cancer

World Journal of Surgical Oncology, 2006
Background Cyclin D1 plays a major role as a potential contributor to the multistep process of oncogenesis; nevertheless its prognostic significance in colon cancer has already been examined in a few studies and needs to be further delineated. The aim of
Giaginis Costas, Vagianos Costas, Glinavou Andromahi, Vamvakas Panayiotis, Theocharis Stamos, Kouraklis Gregory, Sioka Crysoula   +6 more
doaj   +1 more source

Cyclin D1 expression in acute leukemia

Hematology, 2006
Disorders of the cell cycle regulatory machinery play a key role in the pathogenesis of cancer. Over expression of cyclin D1 protein has been reported in several solid tumors and certain lymphoid malignancies, but little is known about the involvement of cyclin D1 in acute leukemia.In this study, we analyzed the expression of cyclin D1 at protein level
Salah, Aref, M, Mabed, M, El-Sherbiny, T, Selim, A, Metwaly   +4 more
openaire   +2 more sources

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol [PDF]

, 2008
Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Androic, Ilija, Yuan Juping, Strebhardt Klaus, Yan Ruilan, Yan, Ruilan, Gätje Regine, Krämer, Andrea, Gätje, Regine, Androic Ilija, Andrea Krämer, Rödel, Franz, Yuan, Juping, Krämer Andrea, Ilija Androic, Manfred Kaufmann, Ruilan Yan, Klaus Strebhardt, Rödel Franz, Strebhardt, Klaus, Juping Yuan, Kaufmann Manfred, Franz Rödel, Regine Gätje, Kaufmann, Manfred   +23 more
core   +2 more sources

Video‐Assisted Intralesional Curettage for Invasive Nonmalignant Giant Cell Tumors

Arthroscopy Techniques, EarlyView.
Abstract Giant cell tumor of bone is a locally aggressive benign neoplasm with a strong tendency for local recurrence after surgical treatment. Intralesional excision and curettage is preferred in most cases to maximize tumor removal while preserving the affected joint.
George Loria, Mohamed Ahmed Mohamed, George Alexander Rublev, Irakli Gogua, Giorgi Zimlitski, Mikheil Zimlitski   +5 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

Haematologica, 2012
Background Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior.
Julia Slotta-Huspenina, Ina Koch, Laurence de Leval, Gisela Keller, Margit Klier, Karin Bink, Marcus Kremer, Mark Raffeld, Falko Fend, Leticia Quintanilla-Martinez   +9 more
doaj   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Cyclin D1 expression in penile cancer. [PDF]

Oncotarget
The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE, Pinho JD, Melo SPDC, Duarte DRD, Carmo JMDGRD, Khayat AS, Calixto JRR, Campos MAG, Correa RDGCF, Júnior AMA, Teixeira-Júnior AAL, Silva GEB.   +11 more
europepmc   +3 more sources