Results 91 to 100 of about 299,961 (316)

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

Molecular Cancer, 2006
Background The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the
Coombes R Charles, Lam Eric, Pomeranz Karen M, Stavropoulou Alexandra V, Gamble Simon C, Alao John P, Vigushin David M   +6 more
doaj   +1 more source

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models*

Journal of Biological Chemistry, 2016
Deubiquitinases are important components of the protein degradation regulatory network. We report the discovery of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biology of USP2 and its putative substrate ...
Mindy I. Davis, R. Pragani, Jennifer T Fox, M. Shen, K. Parmar, Emily F. Gaudiano, Li Liu, C. Tanega, L. McGee, M. Hall, Crystal McKnight, P. Shinn, H. Nelson, D. Chattopadhyay, A. D’Andrea, D. Auld, L. DeLucas, Zhuyin Li, M. Boxer, A. Simeonov   +19 more
semanticscholar   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

Cyclin D1 Expression Is Regulated Positively by the p42/p44MAPK and Negatively by the p38/HOGMAPK Pathway*

Journal of Biological Chemistry, 1996
We have previously shown that the persistent activation of p42/p44MAPK is required to pass the G1 restriction point in fibroblasts (Pagès, G., Lenormand, P., L'Allemain, G., Chambard, J. C., Meloche, S., and Pouysségur, J. (1993) Proc. Natl. Acad. Sci. U.
J. Lavoie, G. l'Allemain, A. Brunet, R. Müller, J. Pouysségur   +4 more
semanticscholar   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress [PDF]

, 2006
The understanding of endothelial cell responses to oxidative stress may provide insights into aging mechanisms and into the pathogenesis of numerous cardiovascular diseases.
CAPOGROSSI MC, BIGLIOLI P, MARTELLI F., FUCILE, Sergio, MAGENTA A, FASANARO P, EUSEBI, Fabrizio, ZACCAGNINI G, CICCHILLITTI L   +8 more
core   +1 more source

Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma

World Journal of Surgical Oncology, 2012
Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu, Cheng Sou-De, Chuang Wen-Yu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Hsieh Ling-Ling   +6 more
doaj   +1 more source

Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1

Journal of experimental & clinical cancer research : CR, 2016
HOXA1 is a member of the Homeobox gene family, which encodes a group of highly conserved transcription factors that are important in embryonic development. However, it has been reported that HOXA1 exhibits oncogenic properties in many malignancies.
Chenwei Yuan, Xingwu Zhu, Yang Han, Chenlong Song, Chenchen Liu, Su Lu, Meng Zhang, Fudong Yu, Zhihai Peng, Chongzhi Zhou   +9 more
semanticscholar   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Cyclin D1 Functions in Cell Migration [PDF]

Cell Cycle, 2006
Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer.
Zhiping, Li, Chenguang, Wang, George C, Prendergast, Richard G, Pestell   +3 more
openaire   +2 more sources