British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian Cancers [PDF]
Cyclin-dependent kinases (CDK2, CDK4, CDK6), cyclin D1, cyclin E1 and phosphorylated retinoblastoma (pRB1) are key regulators of the G1/S cell cycle checkpoint and may influence platinum response in ovarian cancers.
Jennie N. Jeyapalan +17 more
core +2 more sources
Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels
BMC Cell Biology, 2006 Background The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of
Hitomi Masahiro +6 more
doaj +1 more source
Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. [PDF]
PLoS ONE, 2015 Huachansu, a traditional Chinese medicine prepared from the dried toad skin, has been used in clinical studies for various cancers in China. Resibufogenin is a component of huachansu and classified as bufadienolides.
Masami Ichikawa +4 more
doaj +1 more source
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis
OncoTarget, 2015 Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Mathew C. Casimiro +18 more
semanticscholar +1 more source
What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
wiley +1 more source
CYPJ regulates the transcription of cyclin D1. [PDF]
, 2015 (A) Effects of CYPJ overexpression on the expression of several cell cycle controllers. The mRNA levels of each gene were evaluated by quantitative real-time RT-PCR, and subsequently normalized by internal GAPDH ...
Jiahui Wang (746367) +10 more
core +1 more source
Protein expression patterns of cell cycle regulators in operable breast cancer.
PLoS ONE, 2017 Background-aimTo evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes.MethodsCyclin E1, cyclin D1, p53, p21 and p27 were evaluated with ...
Flora Zagouri +23 more
doaj +1 more source
Cyclin D1 Loss Distinguishes Prostatic Small Cell Carcinoma from Most Prostatic Adenocarcinomas
Clinical Cancer Research, 2015 Purpose: Small-cell neuroendocrine differentiation in prostatic carcinoma is an increasingly common resistance mechanism to potent androgen deprivation therapy (ADT), but can be difficult to identify morphologically. We investigated whether cyclin D1 and
H. Tsai +17 more
semanticscholar +1 more source
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation [PDF]
Genes & Development, 2000 GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved. For example, phosphorylation of nuclear cyclin D1 could increase its rate of nuclear export relative to nuclear import ...
J R, Alt +3 more
openaire +2 more sources