Results 111 to 120 of about 259,083 (282)
Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1
, 2000 A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs).
Laurent Meijer +11 more
core +1 more source
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development [PDF]
, 2012 We have previously demonstrated that ras-mediated skin tumorigenesis depends on signaling pathways that act preferentially through cyclin D1 and D2. Interestingly, the expression of cyclin D3 inhibits skin tumor development, an observation that conflicts
Miliani De Marval, Paula L. +9 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao +7 more
wiley +1 more source
Biology of Sex Differences, 2011 Background Although colorectal cancer (CRC) is generally not considered to be a hormone-dependent malignancy, several sex-related differences in incidence, molecular characteristics and survival have been reported.
Wangefjord Sakarias +5 more
doaj +1 more source
New twist in the regulation of cyclin D1
bmc, 2010 Abstract Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of ...
Kato Jun-ya, Yoneda-Kato Noriko
openaire +3 more sources
, 2012 (A) Cyclin D1 depletion by siRNA in A549 cells led to reduced cyclin E expression, but conversely, the expression of cyclin D1 was not significantly changed (p = 0.944) in cells with knocked down cyclin E by siRNA, suggesting a unidirectional regulatory ...
Endi Wang (164292) +6 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast cancer (BC) is poorly understood.
Na Wang, Ming Huang
wiley +1 more source
Cyclin D1 Overexpression in Laryngeal Carcinomas.
Nippon Jibiinkoka Gakkai Kaiho, 1998 Overexpression of cyclin D1 has been found in a variety of malignancies and is suggested to be related to tumor progression. We immunohistochemically investigated the overexpression of cyclin D1 protein in 92 laryngeal carcinomas. Twenty-eight (30.4%) of the carcinoma specimens showed overexpression of cyclin D1.
Wang, Xue-feng +5 more
openaire +3 more sources
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
, 2002 Cyclin D1 and cyclin E are overexpressed in ∼45% and 30% of breast cancers, respectively, and adverse associations with patient outcome have been reported.
Sutherland, Robert L. +5 more
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