Results 101 to 110 of about 259,083 (282)
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm
Gut Medicine, EarlyView.ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang +5 more
wiley +1 more source
Acta Medica Indonesiana, 2020 Background: nasopharyngeal cancer (NPC) is the most common type of head and neck cancer in Indonesia (28.4%). Reports showed that 18.9% of cases came with advanced stage. Chemotherapy play important role in advanced stage. However, patients with the same
Cosphiadi Irawan +4 more
doaj +2 more sources
Kinase independent oncogenic cyclin D1
Aging, 2015 Strong evidence implicates cyclin D1 overexpression as a driving force in breast cancer and many other types of human tumors. Cyclin D1 overexpression is found in up to 50% of human breast cancers, and the pattern of cyclin D1 overexpression in tissues along the spectrum from normal epithelium to invasive breast cancer suggests its involvement in the ...
Casimiro, Mathew C +2 more
openaire +2 more sources
Diagnostic Pathology, 2019 Background Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis.
Nasir Uddin +4 more
doaj +1 more source
Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]
, 2011 A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed.
I. C. Baianu
core
International Journal of Cancer, EarlyView.What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin +9 more
wiley +1 more source
PLoS ONE, 2017 The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein ...
Angela B Ortiz +5 more
doaj +1 more source
MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility
International Journal of Cancer, EarlyView.ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih +10 more
wiley +1 more source
Brucine Inhibits the Proliferation of Human Lung Cancer Cell Line PC-9 via Arresting Cell Cycle
Chinese Journal of Lung Cancer, 2014 Background and objective It has been proven that Cyclin D1 and Cyclin E are the important positive regulators of cell cycle, they are closely related to the tumor proliferation. The aim of this study is to explore the relationship between Brucine and the
Miao LI +4 more
doaj +1 more source