Results 81 to 90 of about 299,961 (316)

New Roles of Cyclin D1

The American Journal of Pathology, 2013
Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of ...
openaire   +2 more sources

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Yu-Chang Huang, Kazunari K. Yokoyama, Koji Nakade, Satoko Masuzaki, Takehide Murata, Naoto Yamaguchi, Hitomi Hasegawa, Yuichi Obata, Jianzhi Pan, Atsushi Yoshiki   +9 more
core   +1 more source

Prolactin Promotes Mammary Pathogenesis Independently from Cyclin D1 [PDF]

, 2012
Epidemiological and experimental studies have revealed an important role for prolactin (PRL) in breast cancer. Cyclin D1 is a major downstream target of PRL in lobuloalveolar development during pregnancy and is amplified and/or overexpressed in many ...
Rugowski, Debra E., Kathleen A. O'Leary, Debra E. Rugowski, Linda A. Schuler, Jennifer M. Asher, Arendt, Lisa M., Schuler, Linda A., Lisa M. Arendt, O'Leary, Kathleen A., Asher, Jennifer M.   +9 more
core   +1 more source

Cyclin D1 expression in multiple myeloma by immunohistochemistry: Case series of 14 patients and literature review

Indian Journal of Medical and Paediatric Oncology, 2013
Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multiple myeloma (MM). This may be detected up to 30% cases by immunohistochemistry (IHC) and up to 40-50% cases by molecular studies.
Somanath Padhi, Renu G′Boy Varghese, Anita Ramdas   +2 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Cyclin D1 and Cdk4 Mediate Development of Neurologically Destructive Oligodendroglioma [PDF]

, 2011
Although the molecular changes that characterize gliomas have been studied, the pathogenesis of tumor development remains unclear. p21 contributes to gliomagenesis by stabilizing cyclin D1–cdk4 kinase complexes, suggesting that cyclin D1 and cdk4 may ...
Yuhui Liu, Eric C. Holland, Daniel Ciznadija, Stephanie M. Pyonteck, Andrew Koff   +4 more
core   +1 more source

Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export

BMC Complementary and Alternative Medicine, 2018
Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park, Gwang Hun Park, Ha Na Kim, Hun Min Song, Ho-Jun Son, Ji Ae Park, Hyun-Seok Kim, Jin Boo Jeong   +7 more
doaj   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Caffeine, Cyclin D1 and Cell Proliferation [PDF]

, 2012
Although well characterized as an inhibitor of DNA damage-induced checkpoint signaling, caffeine has also been reported to delay G1-S-phase cell cycle progression in various cell lines.
Alao, John Patrick,, John P. Alao
core   +1 more source