Results 81 to 90 of about 259,083 (282)
Advanced Science, EarlyView.TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang +8 more
wiley +1 more source
miR-195 downregulates cyclin D1 and cyclin E1 by directly targeting their 3
, 2013 ′-UTRs. A, Predicted miR-195 target sequence in the 3′-UTR of cyclin D1 and cyclin E1 (cyclin D1 3′-UTR and cyclin E1 3′-UTR) and illustration of the three altered nucleotides in miR-195-mut.
Li WenSheng (277431) +6 more
core +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
BMC Complementary and Alternative Medicine, 2019 Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim +7 more
doaj +1 more source
Cyclin D1 and P27KIP1: The Gatekeepers of Dysplasia
, 2018 There is increasing evidence suggesting that cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors (CDIs) either are themselves targets for genetic change in cancer or are disrupted secondarily by other oncogenic events. Cyclin
Bakr, Mahmoud, Guan, Simon, Love, Robert
core
MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer
Annals of Gastroenterological Surgery, EarlyView.Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li +5 more
wiley +1 more source
Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation
, 2007 PURPOSE: To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention.
Betticher, Daniel C +14 more
core +1 more source
Prognostic Significance of Cyclin D1 Expression in Small Intestinal Adenocarcinoma
, 2023 Cyclin D1, a critical cyclin-dependent kinase (CDK) 4/6-dependent regulator of G1/S transition, has attracted much interest as a therapeutic target. The cyclin D1 expression in small intestinal adenocarcinomas (SIACs) has not yet been comprehensively ...
Sun-Young Jun +2 more
core +1 more source
The Anatomical Record, EarlyView.Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli +6 more
wiley +1 more source
Cyclin D1 is a NF-κB corepressor
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 NF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-κB activity. We found that CD1 inhibits NF-κB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3.
Rubio, Maria Fernanda +8 more
openaire +3 more sources