Results 121 to 130 of about 299,961 (316)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Cyclin D1 regulates hepatic estrogen and androgen metabolism [PDF]

, 2010
Mullany LK, Hanse EA, Romano A, Blomquist CH, Mason JI, Delvoux B, Anttila C, Albrecht JH. Cyclin D1 regulates hepatic estrogen and androgen metabolism. Am J Physiol Gastrointest Liver Physiol 298: G884-G895, 2010. First published March 25, 2010; doi: 10.
Blomquist, Charles H., Anttila, Chelsea, Mason, J. Ian, Delvoux, Bert, Romano, Andrea; id_orcid, Albrecht, Jeffrey H., Mullany, Lisa K., Hanse, Eric A., Romano, Andrea   +8 more
core   +1 more source

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2019
Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong   +7 more
doaj   +1 more source

Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells

Biomolecules & Therapeutics, 2015
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. However, more detailed mechanism by which NAR exerts anti-cancer properties still remains unanswered.
Hun Min Song, G. Park, H. Eo, Jin Wook Lee, M. K. Kim, Jeong Rak Lee, M. Lee, J. Koo, J. Jeong   +8 more
semanticscholar   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

CDK-Independent Activation of Estrogen Receptor by Cyclin D1 [PDF]

, 1997
Both cyclin D1 and estrogens have an essential role in regulating proliferation of breast epithelial cells. We show here a novel role for cyclin D1 in growth regulation of estrogen-responsive tissues by potentiating transcription of estrogen receptor ...
Wientjens, Ellen, van der Sman, Jeroen, Michalides, Rob J.A.M, Klompmaker, Rob, Zwijsen, Renate M.L, Bernards, René   +5 more
core   +1 more source

Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression

Nature, 2014
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining glucose homeostasis; dysregulation of this axis causes diabetes. PGC-1α (peroxisome-proliferator-activated receptor-γ coactivator-1α) links insulin signalling to the ...
Yoonjin Lee, John E. Dominy, Y. Choi, M. Jurczak, N. Tolliday, J. Camporez, H. Chim, Ji‐Hong Lim, Hai-Bin Ruan, Xiaoyong Yang, F. Vazquez, P. Sicinski, G. Shulman, P. Puigserver   +13 more
semanticscholar   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development [PDF]

, 2012
We have previously demonstrated that ras-mediated skin tumorigenesis depends on signaling pathways that act preferentially through cyclin D1 and D2. Interestingly, the expression of cyclin D3 inhibits skin tumor development, an observation that conflicts
Miliani De Marval, Paula L., Paula L. Miliani de Marval, Christopher Sistrunk, Rodriguez-Puebla, Marcelo L., Marcelo L. Rodriguez-Puebla, Sistrunk, Christopher, Xian Wang, Yongbaek Kim, Wang, Xian, Kim, Yongbaek   +9 more
core   +2 more sources

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Oncogenesis
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W. Ashton, Zhiping Li, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, Tamas Lazar, Peter Tompa, Chenguang Wang, Zuoren Yu, Zhao Zhang, Kawthar Aldaaysi, Ratna Vadlamudi, Monica Mann, Emmanuel Skordalakes, Andrew Kossenkov, Yanming Du, Richard G. Pestell   +22 more
doaj   +1 more source