Results 141 to 150 of about 259,083 (282)
Distinct Clinical Features of Multiple Myeloma With t(11;14): A Post Hoc Analysis of JSH‐MM‐15 Study
Cancer Science, EarlyView.t(11;14)‐positive MM is a clinically distinct subgroup characterized by intermediate prognostic risk, modest response depth, and treatment‐dependent outcomes. ABSTRACT t(11;14) (q13;q32) occurs in approximately 15%–25% of multiple myeloma (MM) cases and has traditionally been regarded as a standard cytogenetic risk factor.
Taku Tsukamoto +24 more
wiley +1 more source
Immunohistochemistry analysis of cyclin D1 expression in subcutaneous tumor tissues.
, 2017 A: Immunohistochemistry images of cyclin D1 expression in subcutaneous tumor tissues; B: Comparison of the cyclin D1 positive areas between the quercetin-treated and control groups (*p < 0.05).
Zhujuan Xiong (3815341) +6 more
core +1 more source
Cancer Science, EarlyView.LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu +16 more
wiley +1 more source
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma [PDF]
, 2011 The chromosomal translocation t(11;14)(q13;q32) leading to cyclin-D1 overexpression plays an essential role in the development of mantle cell lymphoma (MCL), an aggressive tumor that remains incurable with current treatment strategies. Cyclin-D1 has been
Almada, L.L. (Luciana L.) +17 more
core
Cell Proliferation, EarlyView.This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo +5 more
wiley +1 more source
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
Diagnostic Utility of p16 and MTAP Immunohistochemistry for Cellular Neurothekeomas
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Aims Cellular neurothekeoma (cNTK) is a benign cutaneous tumor of uncertain histogenesis. Recent genomic characterization identified recurrent deletions on chromosome 9p21.3, encompassing CDKN2A (p16), as a primary driver event in cNTK. We assessed the potential utility of p16 and MTAP immunohistochemistry for discriminating cNTKs from ...
Joseph S. Durgin +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong +6 more
wiley +1 more source
A frontal lobe mass in a 6‐year‐old girl
Brain Pathology, EarlyView.
Francesca S. Vacca +5 more
wiley +1 more source
Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix
Histopathology, EarlyView.Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake +12 more
wiley +1 more source