Results 141 to 150 of about 299,961 (316)
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism [PDF]
, 2013 Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma protein.
Muñoz Terol, Alberto +1 more
core +1 more source
Diagnostic Pathology, 2019 Background Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis.
Nasir Uddin +4 more
doaj +1 more source
Cyclin D1 is a NF-κB corepressor
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 NF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-κB activity. We found that CD1 inhibits NF-κB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3.
Rubio, Maria Fernanda +8 more
openaire +3 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Since 2019, coronavirus disease 2019 (COVID‐19) has been associated with increased risks of preterm birth and placental complications. We prospectively investigated alterations in microRNAs (miRNAs) and cytokines in placental and amniotic tissues from pregnant women with and without COVID‐19 to evaluate the infection's impact on pregnancy ...
Wei‐Chun Chen +3 more
wiley +1 more source
Cyclin D1 is one of downstream target genes of Kaiso. [PDF]
, 2012 (A) Western blot analyses show the increased expression of Kaiso in A549 cells transfected with Kaiso cDNA. Kaiso overexpression remarkably down-regulated the expression of cyclin D1 (p = 0.000) and cyclin E (p = 0.003).
Endi Wang (164292) +6 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao +7 more
wiley +1 more source
Acta Medica Indonesiana, 2020 Background: nasopharyngeal cancer (NPC) is the most common type of head and neck cancer in Indonesia (28.4%). Reports showed that 18.9% of cases came with advanced stage. Chemotherapy play important role in advanced stage. However, patients with the same
Cosphiadi Irawan +4 more
doaj +2 more sources
Brucine Inhibits the Proliferation of Human Lung Cancer Cell Line PC-9 via Arresting Cell Cycle
Chinese Journal of Lung Cancer, 2014 Background and objective It has been proven that Cyclin D1 and Cyclin E are the important positive regulators of cell cycle, they are closely related to the tumor proliferation. The aim of this study is to explore the relationship between Brucine and the
Miao LI +4 more
doaj +1 more source
Haematologica, 2012 Background Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior.
Julia Slotta-Huspenina +9 more
doaj +1 more source
Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α
Diabetes, 2014 Hepatic gluconeogenesis is crucial to maintain normal blood glucose during periods of nutrient deprivation. Gluconeogenesis is controlled at multiple levels by a variety of signal transduction and transcriptional pathways. However, dysregulation of these
K. Bhalla +12 more
semanticscholar +1 more source