Results 161 to 170 of about 259,083 (282)

The role of cyclin D1 in nuclear localization in B cell lymphomagenesis

, 2005
The control of cell proliferation is crucial in maintaining cellular homeostasis and loss of this mechanism is a principle hallmark of cancer cells. A primary target of growth factor signaling is the cyclin D1-dependent kinase (D1/CDK4) whose activity ...
Gladden, Andrew B
core  

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Cytoplasmic cyclin D1 modulates brain cortex development. [PDF]

Cell Mol Life Sci
Pedraza N, Rocandio D, Zammou B, Monserrat MV, Ortiz-Brugués A, Marfull-Oromí P, Chauhan D, Encinas M, Dolcet X, Ferrezuelo F, Garí E, Egea J.   +11 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

AI-Assisted Identification of a Putative Allosteric Ligand Targeting the CDK4/Cyclin D1 Protein-Protein Interface. [PDF]

Pharmaceuticals (Basel)
Kurt B.
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

A cyclin D1-CDK4/6-E2F dependency represents an acquired vulnerability in cisplatin-resistant bladder cancer. [PDF]

Biol Direct
Hsieh TH, Kuo HP, Pan CH, Lin YC, Lin BJ, Chen MC, Chen CH.   +6 more
europepmc   +1 more source

Successful Endoscopic Submucosal Dissection for Primary Esophageal Mucosa‐Associated Lymphoid Tissue Lymphoma

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Primary esophageal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) is extremely rare, and its optimal management has not been established. We report a case of primary esophageal MALT lymphoma that was successfully treated by endoscopic submucosal dissection (ESD).
Junya Makiyama, Hiroko Fukuda, Kyoko Minamino, Yukiyoshi Moriuchi, Koichi Ohshima   +4 more
wiley   +1 more source

Incidental CD5 Negative Mantle Cell Lymphoma in a Gastrointestinal Stromal Tumor: An Unusual Case Suspicious for a Non‐Nodal Variant

International Journal of Laboratory Hematology, EarlyView.
Elizabeth Tingey, Ashley Stueck, Ibrahim Elsharawi   +2 more
wiley   +1 more source

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source