Results 171 to 180 of about 259,083 (282)

Response profile and long-term outcomes in Cyclin D1-overexpressing multiple myeloma: insights from the CASSIOPEIA trial. [PDF]

Blood Cancer J
Perrot A, Touzeau C, Minvielle S, Hulin C, Caillot D, Manier S, Leleu X, Sonntag C, Belhadj K, Arnulf B, Chalopin T, Eveillard JR, Escoffre-Barbe M, Karlin L, Vincent L, Macro M, Avet-Loiseau H, Wuilleme S, Boumendil A, Corre J, Moreau P.   +20 more
europepmc   +1 more source

Systems‐level phosphoproteomics reveals calcium/calmodulin‐dependent protein kinase kinase 2‐driven kinase signaling underlying malignant phenotypes in gastric cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
CAMKK2 inhibition induces extensive phosphoproteomic remodeling associated with cell cycle regulation, RNA processing, and kinase signaling networks in gastric cancer. Integrated systems‐level analyses identified dysregulated CDK, SRPK, MAPK, and AKT signaling pathways underlying malignant phenotypes and highlighted CAMKK2 as a potential therapeutic ...
Mohd. Altaf Najar, T. S. Keshava Prasad, Prashant Kumar Modi   +2 more
wiley   +1 more source

eEF2K promotes immune evasion in melanoma via Cyclin D1-mediated stabilization of PD-L1. [PDF]

J Immunol
Ren Y, Ballard DJ, Kumar A, Song AF, Gupta M, Xiong X, Ren X, Das JK, Yang JM, Song J.   +9 more
europepmc   +1 more source

Deubiquitinase USP5 suppresses ferroptosis in lung adenocarcinoma by deubiquitinating and stabilizing GPX3

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
1. USP5 overexpression in LUAD predicts poor prognosis, linking to tumor progression and therapy resistance. 2. USP5 deubiquitinates/stabilizes GPX3, maintaining antioxidant defense against ferroptosis. 3. Targeting inhibition of USP5 enhances LUAD ferroptosis sensitivity, offering therapeutic potential. Abstract Ferroptosis is a regulated form of cell
Xin Fan, Yubiao Lin, Zhigao Zhen, Yingqin Gao, Wenhui Zhen, Siyuan Zeng, Yufei Ji, Kaida Huang, Shuitu Feng   +8 more
wiley   +1 more source

Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratio. [PDF]

Commun Biol
Ferrick KR, Upadhya SW, Fan Y, Ratnayeke N, Teruel MN, Meyer T.   +5 more
europepmc   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

[Retracted] Knockdown of MALAT1 inhibits osteosarcoma progression via regulating the miR‑34a/cyclin D1 axis. [PDF]

Int J Oncol
Duan G, Zhang C, Xu C, Xu C, Zhang L, Zhang Y.   +5 more
europepmc   +1 more source

Network based approach identifies miR‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

The Journal of Pathology, Volume 270, Issue 4, Page 468-480, December 2026.
Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella, Manuela Petti, Zein Mersini Besharat, Caterina Alfano, Elena Splendiani, Sofia Trocchianesi, Sara Cassandro, Martina Chiacchiarini, Claudia Sabato, Francesca Gianno, Tanja Milena Autilio, Martina Brunetti, Giuseppina Catanzaro, Antonella Verrienti, Rossella Elisei, Raffaele Ciampi, Cristina Romei, Maria Grazia Castagna, Silvia Cantara, Vincenzo Marotta, Luciano Pezzullo, Lorenzo Farina, Cosimo Durante, Agnese Po, Elisabetta Ferretti   +24 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, Volume 20, Issue 11, Page 2699-2717, November 2026.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

GDPPH1 induces cell cycle arrest by downregulation of CDK4/Cyclin D1 via the m⁶A-METTL14-YTHDF2 axis, attenuating glioblastoma progression. [PDF]

Cell Death Dis
Li S, Yuan R, Su J, Chen R, Qu X, Zhao L, Zhou X, Zou Q, Zhang Z, Yang S, Lai J, Zhuang X, Li Z, Cui K, Hu S, Liu Y, Liu L, Luo Z, Luo Z, Li W, Yan Y, Zhang Y, Zheng Z, Qi Q.   +23 more
europepmc   +1 more source