Results 191 to 200 of about 154,360 (283)

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Regulatory interplay of cyclin D1 and INSM1 in suppressing INSL6 expression: Implications for breast cancer biology. [PDF]

Biochem Biophys Rep
Homma K, Hasegawa T, Umezu S, Osawa K, Sato H, Sato K, Sakamaki T.   +6 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Immunohistochemical Expression of p16, p53, BCL2, and Cyclin D1 in Gastrointestinal Stromal Tumors: Correlation With Clinicopathological Parameters. [PDF]

Cureus
Zaki MM, Enan ET, Hany H.
europepmc   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer. [PDF]

Cancer Discov
Shirole NH, Kesar D, Lee Y, Goodale A, Syamala S, Kukreja S, Li R, Qiu X, Yu W, Goldman S, Cejas P, Long HW, Adelman K, Doench JG, Sellers WR, Kaelin WG.   +15 more
europepmc   +1 more source

Asiatic Acid Ameliorates MNNG‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis

Phytotherapy Research, Volume 40, Issue 5, Page 2210-2229, May 2026.
ABSTRACT Chronic atrophic gastritis (CAG), a widespread gastrointestinal condition, is widely acknowledged as a precursor to gastric cancer (GC). The incidence of CAG has been steadily increasing, yet effective pharmacological interventions remain unavailable.
Feifei Zhou, Cuiyu Zhu, Wanwan Yuan, Wenkun Peng, Qianqian Xu, Hongli Yang, Ruofan Cao, Ben Wang, Meiqian Wang, Hongwei Xu   +9 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation. [PDF]

Mol Oncol
Cardona-Benavides IJ, Cristobal-Vargas S, De Ramón C, Rojas EA, Misiewicz-Krzeminska I, Isidro I, Pérez JJ, Paiva B, Puig N, Alcoceba M, Mateos MV, Corchete LA, Cuadrado M, Gutiérrez NC.   +13 more
europepmc   +1 more source

Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim The liver exhibits a remarkable regenerative capacity, enabling this organ to maintain homeostasis even after significant injury. However, hepatic regeneration requires sufficient energy to sustain cellular hypertrophy and proliferation, thus ensuring efficient tissue repair.
A. L. Vieira‐da‐Silva, M. V. Esteca, F. A. Silva, I. A. Divino, F. S. Carneiro, E. R. Ropelle, A. S. Torsoni, I. L. Baptista   +7 more
wiley   +1 more source

Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate. [PDF]

Blood Adv
Zhang J, Zhang Z, Liu J, Luan S, Qu J, Wu Z, Kuang Y, Gong P, Bao Y, Wang Y, Yan X, Waxman S, Zhao L, Jing Y.   +13 more
europepmc   +1 more source