Results 191 to 200 of about 299,961 (316)

Cyclin D1 in Regulation of Liver Cancer Stem Cells [PDF]

, 2014
Cancer stem cells (CSCs) are capable of self-renewal, multipotency, in vivo tumorigenicity, and driving metastasis, leading to recurrence of tumor. Thus, novel therapies capable of eliminating CSCs are needed. Cyclin D1 is deregulated in many types
Wang, X, Tsao, G, Poon, RTP, Xia, W
core  

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Successful Endoscopic Submucosal Dissection for Primary Esophageal Mucosa‐Associated Lymphoid Tissue Lymphoma

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Primary esophageal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) is extremely rare, and its optimal management has not been established. We report a case of primary esophageal MALT lymphoma that was successfully treated by endoscopic submucosal dissection (ESD).
Junya Makiyama, Hiroko Fukuda, Kyoko Minamino, Yukiyoshi Moriuchi, Koichi Ohshima   +4 more
wiley   +1 more source

Diagnostic potential of B‐cell translocation gene 2 in IgA nephropathy: Insights from molecular mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Diagnostic value of BTG2 and its immunoregulatory mechanism in IgAN. This study reveals that BTG2 improves immune microenvironment dysregulation, attenuates inflammation, and reduces fibrosis by promoting the expansion of T follicular helper cells, inducing macrophage polarization toward an M2 anti‐inflammatory phenotype, and inhibiting the TGF‐β1 ...
Min Kou, Mo Dan, Juan Cheng, Sheng Ge, Ruimin Ren   +4 more
wiley   +1 more source

Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Xi Yang, Ya Wang, Yanjiao Yi, Yang Yang, Hongjiang Wang   +4 more
wiley   +1 more source

Understanding the Molecular Processes of Obesity and the Anti‐Obesity Properties of Bioactive Substances Found in Tea

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
ABSTRACT Obesity, a severe worldwide health concern, is characterized as an excessive deposit of fat in the human body. It has various ramifications that endanger human health and increase the financial expense. Obesity raises the risk of several illnesses, notably cardiovascular disease, NALFD, and diabetes, and has been associated with shorter ...
Sakhawat Riaz, Fan Wenni, Danish Kamal, Umber Mubeen, Abul Hassan, Arslan Ahmed, Munir Ahmed   +6 more
wiley   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Cytoplasmic cyclin D1 modulates brain cortex development. [PDF]

Cell Mol Life Sci
Pedraza N, Rocandio D, Zammou B, Monserrat MV, Ortiz-Brugués A, Marfull-Oromí P, Chauhan D, Encinas M, Dolcet X, Ferrezuelo F, Garí E, Egea J.   +11 more
europepmc   +1 more source