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Potential oncogenic role of occult hepatitis B virus pre-S mutations: Activation of Akt/mTOR/Cyclin D1 signaling drives cell cycle dysregulation and proliferation in hepatocellular carcinogenesis. [PDF]
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Breast Cancer Research and Treatment, 1998
Cyclin D1 protein plays an important part in regulating the progress of the cell during the G1 phase of the cell cycle. The cyclin D1 gene, CCND1, is amplified in approximately 20% of mammary carcinomas, and the protein is over-expressed in approximately 50% of cases. This has led to intensive study to ascertain whether cyclin D1 is a biological marker
D M, Barnes, C E, Gillett
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Cyclin D1 protein plays an important part in regulating the progress of the cell during the G1 phase of the cell cycle. The cyclin D1 gene, CCND1, is amplified in approximately 20% of mammary carcinomas, and the protein is over-expressed in approximately 50% of cases. This has led to intensive study to ascertain whether cyclin D1 is a biological marker
D M, Barnes, C E, Gillett
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Cyclin D1 expression in gliomas
Acta Neuropathologica, 1998Cyclin D1 (cycD1) expression was defined immunohistochemically using monoclonal antibody DCS-6 and polyclonal antiserum H-295 in 50 glioma biopsies. The number of positive nuclei was higher for H-295 than for DCS-6, with a ratio of 3:1. The labelling index (LI) was compared to the grade of histological malignancy and to Ki-67 MIB-1 LI. The LI for cycD1
CAVALLA P +5 more
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Cyclin D1 as a target for chemoprevention
Lung Cancer, 2003Lung cancer is the leading cause of cancer mortality. Chemoprevention is an attractive strategy to combat this major public health problem. Pre-clinical and clinical studies have identified diverse candidate chemopreventive agents that affect cellular proliferation, differentiation, apoptosis and tumor angiogenesis, among other pathways.
W Jeffrey, Petty +2 more
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Cyclin D1 Immunoreactivity in Meningiomas
Cellular and Molecular Neurobiology, 2008Cyclin D1 is an important nuclear protein required for progression of cells through the G1 phase of the cell cycle. The proliferative potential of meningiomas has been studied using various proliferative markers. However, there have been only few published studies evaluating Cyclin D1 immunoreactivity in meningiomas.The aim of our study was to analyze ...
Sanja, Milenković +5 more
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Cyclin D1 in mammary carcinoma
The Journal of Pathology, 1997The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer.
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Cyclin D1 as a cellular proto-oncogene
Seminars in Cancer Biology, 1995Deregulated expression of cyclin D1 occurs in several types of human cancer. Since it often results from a specific chromosomal abnormality, this over-expression is likely to be significant in the development of the disease. Cyclin D1 is also implicated in virally induced tumors in mice and transgenic models based on ectopic expression if cyclin D1 ...
S, Bates, G, Peters
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Cyclin D1 positive follicular lymphoma
Journal of Clinical Pathology, 2009This report describes an unusual case of cyclin D1 expression by an otherwise typical follicular lymphoma, of low histological grade. BCL2–IGH and CCND1–IGH fusions were identified by interphase fluorescence in situ hybridisation.
B, Olsen +4 more
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The activities of cyclin D1 that drive tumorigenesis
Trends in Molecular Medicine, 2004The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of human tumors from diverse histological origins. It has long been assumed that the action of cyclin D1, as an activator of cdk4 and cdk6 and leading to progression through the G1 phase of the cell cycle, underlies its pathological activity.
Mark E, Ewen, Justin, Lamb
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