Results 151 to 160 of about 299,961 (316)

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Transcriptional regulation by a DNA-associated form of cyclin D1. [PDF]

, 2005
Besides its function as a cell cycle regulator, cyclin D1 interacts with transcription factors to regulate gene activation. In this study, we show that cyclin D1 is recruited to the p21waf1 promoter by a STAT3-NcoA complex.
B. Barré, Olivier Coqueret, Sylvie Avril, O. Coqueret, Frédéric Bienvenu, Benjamin Barré, Bienvenu, Frédéric, Sandrine Giraud, Barré, Benjamin, Coqueret, Olivier, Avril, Sylvie, S. Giraud, F. Bienvenu, S. Avril, Giraud, Sandrine   +14 more
core   +2 more sources

Kinase independent oncogenic cyclin D1

Aging, 2015
Strong evidence implicates cyclin D1 overexpression as a driving force in breast cancer and many other types of human tumors. Cyclin D1 overexpression is found in up to 50% of human breast cancers, and the pattern of cyclin D1 overexpression in tissues along the spectrum from normal epithelium to invasive breast cancer suggests its involvement in the ...
Casimiro, Mathew C, Arnold, Andrew, Pestell, Richard   +2 more
openaire   +2 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Regulation of cyclin D1 RNA stability by SNIP1 [PDF]

, 2008
Cyclin D1 expression represents one of the key mitogen-regulated events during the G1 phase of the cell cycle, whereas Cyclin D1 overexpression is frequently associated with human malignancy.
Perkins, N., Panov, Konstantin; id_orcid, Bracken, C., Panov, K., Ajuh, P.M., Bracken, Cameron P., Wall, S., Barre, B., Wall, Steven J., Barré, Benjamin, Perkins, Neil D., Perkins, N.D., Panov, Kostya I., Bracken, C.P., Ajuh, P., Ajuh, Paul M., Wall, S.J.   +16 more
core   +1 more source

New twist in the regulation of cyclin D1

bmc, 2010
Abstract Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of ...
Kato Jun-ya, Yoneda-Kato Noriko
openaire   +3 more sources

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, EarlyView.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions (*)

Journal of Biological Chemistry, 1995
Several different oncogenes and growth factors promote G1 phase progression. Cyclin D1, the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of shortening, the G1 phase of the cell cycle. The present study demonstrates
C. Albanese, J. Johnson, G. Watanabe, Nathan W. Eklund, D. Vu, A. Arnold, R. Pestell   +6 more
semanticscholar   +1 more source

Cyclin D1 Overexpression in Laryngeal Carcinomas.

Nippon Jibiinkoka Gakkai Kaiho, 1998
Overexpression of cyclin D1 has been found in a variety of malignancies and is suggested to be related to tumor progression. We immunohistochemically investigated the overexpression of cyclin D1 protein in 92 laryngeal carcinomas. Twenty-eight (30.4%) of the carcinoma specimens showed overexpression of cyclin D1.
Wang, Xue-feng, Nakashima, Torahiko, Masuda, Muneyuki, Matsui, Katsuko, Yamamoto, Tomoya, Komiyama, Sohtaro   +5 more
openaire   +3 more sources