Results 51 to 60 of about 299,961 (316)

Cyclin D1 as a Useful Marker for the Differentiation of Ewing’s Sarcoma from Rhabdomyosarcoma

Middle East Journal of Cancer, 2020
Background: The main oncogenic action of CD99 and cyclin D1 biomarkers is referred to any mutation, amplification, and overexpression in cyclin D1 coding gene, altering cell cycle progression as the main mechanism observed in a variety of tumors.
Tina Shooshtarizadeh, Ladan Fereidooni, Dorna Motevalli   +2 more
doaj   +1 more source

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma.

Blood, 2019
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1. However, a small subset of cyclin D1- MCL has been recognized, and approximately one-half of them harbor CCND2 translocations ...
D. Martín-García, A. Navarro, R. Valdés-Mas, G. Clot, J. Gutiérrez-Abril, Míriam Prieto, Inmaculada Ribera‐Cortada, R. Woroniecka, G. Rymkiewicz, S. Bens, L. de Leval, A. Rosenwald, J. Ferry, E. Hsi, K. Fu, J. Delabie, D. Weisenburger, D. de Jong, F. Climent, S. O'Connor, S. Swerdlow, D. Torrents, Sergi Beltran, B. Espinet, B. González-Farré, L. Veloza, D. Costa, E. Matutes, R. Siebert, G. Ott, L. Quintanilla‐Martinez, E. Jaffe, C. López‐Otín, I. Salaverria, X. Puente, E. Campo, S. Beá   +36 more
semanticscholar   +1 more source

Cycling to Cancer with Cyclin D1 [PDF]

Cancer Biology & Therapy, 2002
Genetic aberrations in the regulatory circuits that govern transit through the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations. Cyclin D1 accumulates and activates its cognate CDK (CDK4/6) in response to mitogenic growth factors in ...
openaire   +2 more sources

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Genes & Development, 1993
A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase. We have studied cyclin D1, a putative G1 cyclin, in normal diploid
ronique Baldin, J. Lukas, Maria Jesfis Marcote, M. Pagano, G. Draetta   +4 more
semanticscholar   +1 more source

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Hepatology, 2018
Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)‐
Shan-Ying Wu, S. Lan, Shang-Rung Wu, Yen-Chi Chiu, Xi-Zhang Lin, I. Su, T. Tsai, C. Yen, T. Lu, F. Liang, Chung-Yi Li, H. Su, C. Su, H-S Liu   +13 more
semanticscholar   +1 more source

An update on the implications of cyclin D1 in melanomas [PDF]

Pigment Cell & Melanoma Research, 2020
AbstractCyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation.
Lucia González‐Ruiz, Miguel Ángel González‐Moles, Isabel González‐Ruiz, Isabel Ruiz‐Ávila, Ángela Ayén, Pablo Ramos‐García   +5 more
openaire   +3 more sources

Cyclin D1 and breast cancer

The Breast, 2006
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues.
Pankaj G, Roy, Alastair M, Thompson
openaire   +2 more sources

The cyclin D1 expression in hepatocellular carcinoma. [PDF]

, 2013
A- the immunoreactivity of cyclin D1 in HCC tumor; B- the cyclin D1 immunoreactivity in fibrolamellar carcinoma; scale bar 5 µm; C- Spearman's rank graph showing a negative correlation between the SHP and cyclin D1 immunoreactivity in G3 hepatocellular ...
Ewa Wilczek (88420), Grzegorz M. Wilczynski (231452), Aleksander Wasiutynski (334445), Barbara Gornicka (334446), Dominika Lukasik (334443), Lukasz Koperski (334444), Magdalena Winiarska (88418), Grzegorz Szparecki (334442)   +7 more
core   +1 more source

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

Acta Pharmaceutica Sinica B
Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu, Ming Zhang, Hongyu Qin, Siyu Shen, Haiqing Song, Hua Jiang, Chunxiang Zhang, Guozhi Xiao, Liping Tong, Qing Jiang, Di Chen   +10 more
doaj   +1 more source

An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas

Diagnostic Pathology, 2013
Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases
Wang Yu, Zhu Jin-fu, Liu Ying-ying, Han Gui-ping   +3 more
doaj   +1 more source