Results 51 to 60 of about 154,360 (283)

Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b) [PDF]

, 2009
Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870).
Benavides, Fernando, Blando, Jorge, Cardenas, Kim, Conti, Claudio, Johnson, David G., Knudsen, Erik S., Pérez, Carlos, Richie, Ellen, Rodriguez Puebla, Marcelo L., Rojas, Paola Andrea, Senderowicz, Adrian M.   +10 more
core   +1 more source

Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India [PDF]

Archive of Oncology, 2018
Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. The percent-age of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced.
Ahmad Gatoo Manzoor, Mahmood Dar Ayaz
doaj  

Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a [PDF]

, 2017
USP2a is a deubiquitinase responsible for stabilization of cyclin D1 – a crucial regulatorbof cell cycle progression and a proto-oncoprotein overexpressed in numerous cancer types.
Alao, Bartkova, Beers, Bernstein, Chambard, Cheng, Coverley, Davis, Diehl, Diehl, Farhana, Fukami-Kobayashi, Goldberg, Grillo, Hofmann, Houten, Issaenko, Jackson, Katona, Kim, Matulis, Musgrove, Májer, Nagengast, Nicholson, Pantoliano, Payne, Prasad, Renatus, Ritorto, Sa, Schneider, Shan, Sharma, Sherr, Shi, Shimura, Singh, Stacey, Staels, Tari, van Kuppeveld, Vogel, Wachs, Yin, Yui   +45 more
core   +4 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

Cell Division, 2007
Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I, Barbash Olena, Diehl J Alan   +2 more
doaj   +1 more source

Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma [PDF]

, 2006
Background Cyclin D1 and p16 are involved in the regulation of G1 checkpoint and may play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC).
Berry, Gerald J, Fee, Willard E, Jr, Lin, Ho-Sheng, Sun, Zijie   +3 more
core   +3 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In Vivo [PDF]

, 2013
Some phytochemicals with the characteristics of cytotoxicity and/or antimetastasis have generated intense interest among the anticancer studies. In this study, a natural flavonoid baicalein was evaluated in bladder cancer in vitro and in vivo.
Jiann-Der Wu, Jin-Yi Wu, Kun-Wei Tsai, Yi-Chien Lai, Yi-Sheng Chang, Yi-Wen Liu, Yi-Zhen Li, Yu-Han Laio   +7 more
core   +1 more source

Cyclin d1 expression in odontogenic cysts [PDF]

Turkish Journal of Pathology, 2013
In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions.Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n ...
Nasim, Taghavi, Shirin, Modabbernia, Alireza, Akbarzadeh, Samad, Sajjadi   +3 more
openaire   +2 more sources