Results 51 to 60 of about 250,304 (196)
Aberrant Expression of Cyclin D1 in Cancer [PDF]
Signal Transduction Insights, 2015 Cyclin D1 binds and activates cyclin-dependent kinases 4/6 (Cdk4/6) to phosphorylate the retinoblastoma (RB) family proteins, relieving E2F/DPs from the negative restraint of RB proteins and histone deacetylases (HDACs). The cyclin D-Cdk4/6 complexes activate cyclin E/Cdk2 through titration of the Cdk inhibitors p21Cip1/p27Kip1.
Kazushi, Inoue, Elizabeth A, Fry
openaire +2 more sources
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]
, 2009 We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Yu-Chang Huang +9 more
core
Cyclin D1 immunohistochemical expression and somatic mutations in canine oral melanoma
, 2019 Canine oral melanoma (COM) is the most frequent tumour with oral localization in dogs. Copy number gains and amplifications of CCND1, a gene coding for Cyclin D1, are the most frequent chromosomal aberrations described in human non-UV induced melanomas ...
Iussich, Selina +23 more
core +1 more source
Indian Journal of Medical and Paediatric Oncology, 2013 Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multiple myeloma (MM). This may be detected up to 30% cases by immunohistochemistry (IHC) and up to 40-50% cases by molecular studies.
Somanath Padhi +2 more
doaj +1 more source
The American Journal of Pathology, 2013 Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of ...
openaire +2 more sources
BMC Complementary and Alternative Medicine, 2018 Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park +7 more
doaj +1 more source
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
Molecular Cancer, 2006 Background The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the
Coombes R Charles +6 more
doaj +1 more source
Regulation of cyclin D1 gene expression
Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. in different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas ...
Witzel II, Koh LF, Perkins ND
core +5 more sources
The role of anchorage in cell cycle control [PDF]
, 2009 Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint ...
Cremona, C.A.
core
Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma
World Journal of Surgical Oncology, 2012 Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu +6 more
doaj +1 more source