Results 31 to 40 of about 154,360 (283)

Consequence of the tumor-associated conversion to cyclin D1b. [PDF]

, 2015
Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to
Akihiro Yoshida, Augello MA, Bigoni R, Bosch F, Carrere N, Erhe Gao, Felix Y Feng, Jeffrey L Benovic, Jeffry L Dean, John Alan Diehl, Karen E Knudsen, Knudsen KE, Lisa D Berman‐Booty, Lu F, Matthew J Schiewer, Michael A Augello, Petre‐Draviam CE, Powers JT, Richard Carr, Scott A Tomlins, Walter J Koch   +20 more
core   +7 more sources

Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation

Frontiers in Endocrinology, 2019
Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals.
Louis Masclef, Vanessa Dehennaut, Marlène Mortuaire, Céline Schulz, Maïté Leturcq, Tony Lefebvre, Anne-Sophie Vercoutter-Edouart   +6 more
doaj   +1 more source

The extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim, Dondu Nergiz, Canan Sadullahoglu, Zelal Akgunduz, Senay Yildirim, Selen Dogan, Cem Sezer   +6 more
doaj   +1 more source

Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer

Current Issues in Molecular Biology, 2022
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha   +7 more
doaj   +1 more source

Direct repression of cyclin d1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition [PDF]

, 2007
Zinc finger transcription factors of the Snail/Slug and ZEB-1/SIP1 families control epithelial-mesenchymal transitions in development in cancer. Here, we studied SIP1-regulated mesenchymal conversion of epidermoid A431 cells.
Jakob Mejlvang, Marina Kriajevska, Cindy Vandewalle, Tatyana Chernova, A. Emre Sayan, Geert Berx, J. Kilian Mellon, Eugene Tulchinsky, Ben Margolis, Aigner K., Andersen H., Batlle E., Berx G., Blanco M. J., Bolos V., Brockbank E. C., Burstyn-Cohen T., Cano A., Carver E., Christofori G., Comijn J., De Craene B., De Craene B., Dohadwala M., Eger A., Elloul S., Franci C., Furusawa T., Guilford P., Imamichi Y., Imai T., Jiang R., Jorda M., Krishnamachary B., Knudsen K. E., Lin S., Lochter A., Maeda G., Malumbres M., McGarry L., Mejlvang J., Moreno-Bueno G., Murray S., Ohkubo T., Patrone G., Peinado H., Perez-Moreno M. A., Postigo A., Remacle J., Rosivatz E., Shy Y., Spoelstra N., Sugimachi K., Taki M., Thiery J. P., Thiery J. P., Turner F., van de Putte T., van Grunsven L. A., van Grunsven L. A., Vandewalle C., Vega S., Walker J. L., Walker J. L., Zhou B. P.   +64 more
core   +2 more sources

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +4 more sources

Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner [PDF]

, 2011
Neural stem and progenitor cells undergo an important transition from proliferation to differentiation in the G1 phase of the cell cycle. The mechanisms coordinating this transition are incompletely understood.
A. I. Lukaszewicz, Altman, Bae, Bertrand, Bienvenu, Briscoe, Budirahardja, Bylund, Bystron, Calegari, Cremisi, D. J. Anderson, Dasen, Dehay, Dehay, Donovan, Fior, Glover, Gui, Hinds, Humbert, Huttner, Jhas, Kageyama, Kerkhoff, Koyano-Nakagawa, Kuida, Lange, Lobjois, Lukaszewicz, Ma, Massagu  , Megason, Mizutani, O'Leary, Ohnuma, Perez, Rao, Rao, Roztocil, Sherr, Tanabe, Tsuchida, Ulloa, White, Zhao, Zhou   +46 more
core   +3 more sources

Galectin-3 and cyclin D1 expression in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2011
Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin, Kowal Aneta, Piesiak Paweł, Kosacka Monika, Jankowska Renata   +4 more
doaj   +1 more source

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth [PDF]

, 2017
The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast ...
Addya, Ashkar, Banerjee, Ben-Ze’ev, Bissell, Blagosklonny, Bosco, Broering, Bronte, Burbelo, Calvo, Chambon, Cox, Cullen, Cullen, Cullen, Dubois, Engelhardt, Epstein, Ertel, Esumi, Fusenig, Garcia, Grotendorst, Hanahan, Hopkinson, Hortobagyi, Howell, Jain, Jeannin, Jecrois, Jukkola-Vuorinen, Kalluri, Kang, Leung, Levine, Liaw, Lisanti, Lisanti, Lisanti, Lisanti, Mann, Martinez-Outschoorn, Matrisian, McKeehan, Nagaraj, Nakamura, Nevalainen, Orimo, Papanikolaou, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pollard, Pollard, Pollard, Pollard, Pollard, Pontén, Prisco, Rimm, Rui, Rushton, Rønnov-Jessen, Sakakura, Samant, Scherer, Sicinski, Soloff, Sotgia, Soucek, Speicher, Speicher, Tanes, Tang, Tarkowski, Uede, Wang, Weinberg, Weinberg, West, Wong, Xiang   +90 more
core   +3 more sources

The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma [PDF]

, 2007
Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis.
Arnerlov C, Berry N, Camp RL, Croce MV, Gendler S, Gendler SJ, Hayes DF, Hilkens J, Kohlgraf KG, Ligtenberg MJ, Wesseling J   +10 more
core   +2 more sources