Results 31 to 40 of about 299,961 (316)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol [PDF]

, 2008
Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Androic, Ilija, Yuan Juping, Strebhardt Klaus, Yan Ruilan, Yan, Ruilan, Gätje Regine, Krämer, Andrea, Gätje, Regine, Androic Ilija, Andrea Krämer, Rödel, Franz, Yuan, Juping, Krämer Andrea, Ilija Androic, Manfred Kaufmann, Ruilan Yan, Klaus Strebhardt, Rödel Franz, Strebhardt, Klaus, Juping Yuan, Kaufmann Manfred, Franz Rödel, Regine Gätje, Kaufmann, Manfred   +23 more
core   +1 more source

Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase [PDF]

Molecular and Cellular Biology, 2003
The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest.
J Alan, Diehl, Wensheng, Yang, Ronald A, Rimerman, Hua, Xiao, Andrew, Emili   +4 more
openaire   +2 more sources

Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2017
Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim, Jin Boo Jeong   +6 more
doaj   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation [PDF]

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation

Cell Division, 2008
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj   +1 more source

Cyclin D1, Cancer Progression and Opportunities in Cancer Treatment

Journal of molecular medicine, 2016
Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle transition from G1 to S phase.
Shuo Qie, J. Diehl
semanticscholar   +1 more source

Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation [PDF]

, 2007
PURPOSE: To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention.
Betticher, Daniel C, Oliver Gautschi, Gautschi, Oliver, Daniel C. Betticher, Jim Heighway, Ratschiller, Daniel, Daniel Ratschiller, Gugger, Mathias, Heighway, Jim, Mathias Gugger   +9 more
core   +1 more source

Histone deacetylase inhibitor, Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells

Molecular Cancer, 2006
Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R, Lam Eric, Stavropoulou Alexandra V, Alao John P, Vigushin David M   +4 more
doaj   +1 more source

Cyclin D1 goes metabolic [PDF]

Cell Cycle, 2012
Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
openaire   +2 more sources