Results 31 to 40 of about 250,304 (196)

Galectin-3 and cyclin D1 expression in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2011
Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin, Kowal Aneta, Piesiak Paweł, Kosacka Monika, Jankowska Renata   +4 more
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Regulation of Cyclin D1 by Calpain Protease [PDF]

Journal of Biological Chemistry, 1997
Cyclin D1, a critical positive regulator of G1 progression, has been implicated in the pathogenesis of certain cancers. Regulation of cyclin D1 occurs at the transcriptional and posttranscriptional level. Here we present evidence that cyclin D1 levels are regulated at the posttranscriptional level by the Ca2+-activated protease calpain.
Y H, Choi, S J, Lee, P, Nguyen, J S, Jang, J, Lee, M L, Wu, E, Takano, M, Maki, P A, Henkart, J B, Trepel   +9 more
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Cycling to Cancer with Cyclin D1 [PDF]

Cancer Biology & Therapy, 2002
Genetic aberrations in the regulatory circuits that govern transit through the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations. Cyclin D1 accumulates and activates its cognate CDK (CDK4/6) in response to mitogenic growth factors in ...
openaire   +2 more sources

Cyclin d1 expression in odontogenic cysts [PDF]

Turkish Journal of Pathology, 2013
In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions.Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n ...
Nasim, Taghavi, Shirin, Modabbernia, Alireza, Akbarzadeh, Samad, Sajjadi   +3 more
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Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
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Cyclin D1 as a Useful Marker for the Differentiation of Ewing’s Sarcoma from Rhabdomyosarcoma

Middle East Journal of Cancer, 2020
Background: The main oncogenic action of CD99 and cyclin D1 biomarkers is referred to any mutation, amplification, and overexpression in cyclin D1 coding gene, altering cell cycle progression as the main mechanism observed in a variety of tumors.
Tina Shooshtarizadeh, Ladan Fereidooni, Dorna Motevalli   +2 more
doaj   +1 more source

The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]

, 2012
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
Madhuri, K, Giannopoulos, T, P Chivers, D P Lovell, Crook, T, H M Coley, E Papacharalbous, T Giannopoulos, Coley, HM, Butler-Manuel, S, S Butler-Manuel, K Madhuri, Papacharalbous, E, Lovell, DP, N A M Safuwan, Safuwan, NA, T Crook, Chivers, P   +17 more
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Cyclin D1 and breast cancer

The Breast, 2006
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues.
Pankaj G, Roy, Alastair M, Thompson
openaire   +2 more sources

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

Acta Pharmaceutica Sinica B
Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu, Ming Zhang, Hongyu Qin, Siyu Shen, Haiqing Song, Hua Jiang, Chunxiang Zhang, Guozhi Xiao, Liping Tong, Qing Jiang, Di Chen   +10 more
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An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas

Diagnostic Pathology, 2013
Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases
Wang Yu, Zhu Jin-fu, Liu Ying-ying, Han Gui-ping   +3 more
doaj   +1 more source