Results 11 to 20 of about 259,083 (282)
Cyclin D1 expression in prostate carcinoma [PDF]
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
doaj +6 more sources
The double dealing of cyclin D1 [PDF]
Cell Cycle, 2019 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
Tchakarska, Guergana, Sola, Brigitte
openaire +6 more sources
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]
Cell, 1999 D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y +7 more
core +6 more sources
Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation [PDF]
Frontiers in Endocrinology, 2019 Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals.
Louis Masclef +6 more
doaj +2 more sources
Role of cyclin D1 in breast carcinoma
Journal of Research in Medical Sciences, 2013 Background: Breast carcinoma is the most frequent cancer among women with considerable invasive and metastatic behavior. CCND1, the oncogene encoding cyclin D1, is amplified in a substantial proportion of human cancers.
Fereshteh Mohammadizadeh +3 more
doaj +3 more sources
Cyclin D1 Induces Chromosomal Instability [PDF]
Oncotarget, 2012 We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly with CIN. We also used a mammary gland targeted model (MMTV) to continuously express cyclin D1.
Casimiro, Mathew C, Pestell, Richard
core +5 more sources
A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription [PDF]
OncogenesisThe essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao +22 more
doaj +3 more sources
Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression [PDF]
Cancer Science, 2007 Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1‐ to S‐phase and for DNA replication.
Etsu, Tashiro +2 more
openaire +2 more sources
Cyclin D1 in parathyroid disease [PDF]
Frontiers in Bioscience, 2000 Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH. So far, abnormalities in two genes, cyclin D1 and MEN1, have been implicated in the development of parathyroid adenomas.
S M, Mallya, A, Arnold
openaire +2 more sources
Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms [PDF]
, 2018 Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored.
Beà, Sílvia +16 more
core +2 more sources