Results 11 to 20 of about 299,961 (316)
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]
Cell, 1999 D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y +7 more
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Role of cyclin D1 in breast carcinoma [PDF]
Journal of Research in Medical Sciences, 2013 Background: Breast carcinoma is the most frequent cancer among women with considerable invasive and metastatic behavior. CCND1, the oncogene encoding cyclin D1, is amplified in a substantial proportion of human cancers.
Fereshteh Mohammadizadeh +3 more
doaj +3 more sources
Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation [PDF]
Frontiers in Endocrinology, 2019 Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals.
Louis Masclef +6 more
doaj +3 more sources
Cyclin D1 Induces Chromosomal Instability [PDF]
Oncotarget, 2012 We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly with CIN. We also used a mammary gland targeted model (MMTV) to continuously express cyclin D1.
Casimiro, Mathew C, Pestell, Richard
openaire +5 more sources
PARP14 regulates cyclin D1 expression to promote cell cycle progression
Oncogene, 2021 Cyclin D1 is an essential regulator of the G1–S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways.
M. O’Connor +3 more
semanticscholar +1 more source
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
eLife, 2023 Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu +5 more
doaj +1 more source
Cells, 2020 Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis of cancer determining uncontrolled cellular proliferation.
F. Montalto, F. De Amicis
semanticscholar +1 more source
Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma
Frontiers in Oncology, 2023 Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression.
Wei Cai +5 more
doaj +1 more source
Cyclin D1 in parathyroid disease [PDF]
Frontiers in Bioscience, 2000 Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH. So far, abnormalities in two genes, cyclin D1 and MEN1, have been implicated in the development of parathyroid adenomas.
S M, Mallya, A, Arnold
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