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Cyclin D1 and human neoplasia [PDF]
Molecular Pathology, 1998 Neoplasia is characterised by abnormal regulation of the cell cycle. Cyclin D1 is a protein derived from the PRAD1, CCND1 or bcl-1 gene on chromosome 11q13, which is involved in both normal regulation of the cell cycle and neoplasia. In the G1 (resting) phase of the cell cycle, cyclin D1 together with its cyclin dependent kinase (cdk) partner, is ...
R, Donnellan, R, Chetty
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BMC Complementary and Alternative Medicine, 2017 Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park +6 more
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Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase [PDF]
Molecular and Cellular Biology, 2003 The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest.
J Alan, Diehl +4 more
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HIV-1 expression induces cyclin D expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy [PDF]
, 2002 Background The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium ...
Peter J Nelson +3 more
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Cell Division, 2008 Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
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Cyclin D1 goes metabolic [PDF]
Cell Cycle, 2012 Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
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Cytoplasmic cyclin D1 regulates glioblastoma dissemination [PDF]
The Journal of Pathology, 2019 AbstractGlioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The cyclin D1 (Ccnd1)/Cdk4–retinoblastoma 1 (RB1) axis is frequently altered in GBM, leading to overproliferation by RB1 deletion or by Ccnd1‐Cdk4 overactivation.
Tània Cemeli +12 more
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Molecular Cancer, 2006 Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R +4 more
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Transcriptional role of cyclin D1 in development revealed by a “genetic-proteomic” screen [PDF]
, 2010 Author manuscript: 2010 September 22.Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers[superscript 1, 2]. The full repertoire of cyclin D1 functions in normal development and oncogenesis is unclear at
A Flora +47 more
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Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression [PDF]
Cancer Science, 2007 Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1‐ to S‐phase and for DNA replication.
Etsu, Tashiro +2 more
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