Results 21 to 30 of about 299,961 (316)
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. [PDF]
PLoS ONE, 2006 Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
Hiroshi Okabe +5 more
doaj +1 more source
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
Nature Communications, 2020 Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer.
Qianfeng Shi +14 more
semanticscholar +1 more source
Nature Metabolism, 2020 Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient in older organisms.
Jamie O. Brett +14 more
semanticscholar +1 more source
P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. [PDF]
PLoS ONE, 2012 BackgroundThe different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date.Methods and findingsWe found that both cyclin D1 and cyclin E could be effectively restored by ...
Guiyang Jiang +6 more
doaj +1 more source
Cyclin D1 and Chemotherapy Response
, 2021 Cyclin D1 is a protein that plays a role in the transition from the G1 to S phase of the cell cycle. Cyclin D1 expression has been found to increase in various malignancies and, in many studies, was associated with tumor growth, stage, lymph node ...
Rahmat Cahyanur, C. Irawan
semanticscholar +1 more source
The cyclin D1b splice variant: an old oncogene learns new tricks
Cell Division, 2006 The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
doaj +1 more source
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. [PDF]
PLoS Pathogens, 2011 EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator of G1 to S phase progression, is tightly associated and aberrantly expressed in numerous human cancers ...
Abhik Saha +7 more
doaj +1 more source
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
Genes & Development, 1998 The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cyclins and their assembly into holoenzyme complexes depend
J. Diehl, M. Cheng, M. Roussel, C. Sherr
semanticscholar +1 more source
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Cell Reports, 2020 N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation. Herein, we demonstrate that fat mass and obesity-associated (FTO) demethylates m6A modification
Mayumi Hirayama +10 more
semanticscholar +1 more source
Cyclin D1 and human neoplasia [PDF]
Molecular Pathology, 1998 Neoplasia is characterised by abnormal regulation of the cell cycle. Cyclin D1 is a protein derived from the PRAD1, CCND1 or bcl-1 gene on chromosome 11q13, which is involved in both normal regulation of the cell cycle and neoplasia. In the G1 (resting) phase of the cell cycle, cyclin D1 together with its cyclin dependent kinase (cdk) partner, is ...
R, Donnellan, R, Chetty
openaire +2 more sources