Results 21 to 30 of about 250,304 (196)

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol [PDF]

, 2008
Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Androic, Ilija, Yuan Juping, Strebhardt Klaus, Yan Ruilan, Yan, Ruilan, Gätje Regine, Krämer, Andrea, Gätje, Regine, Androic Ilija, Andrea Krämer, Rödel, Franz, Yuan, Juping, Krämer Andrea, Ilija Androic, Manfred Kaufmann, Ruilan Yan, Klaus Strebhardt, Rödel Franz, Strebhardt, Klaus, Juping Yuan, Kaufmann Manfred, Franz Rödel, Regine Gätje, Kaufmann, Manfred   +23 more
core   +2 more sources

Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2017
Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim, Jin Boo Jeong   +6 more
doaj   +1 more source

Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase [PDF]

Molecular and Cellular Biology, 2003
The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest.
J Alan, Diehl, Wensheng, Yang, Ronald A, Rimerman, Hua, Xiao, Andrew, Emili   +4 more
openaire   +2 more sources

Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation

Cell Division, 2008
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj   +1 more source

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Popp, Oliver, Nalabothula, Narasimharao, Gil-Parrado, S., Jochum, M., Ghosh, M., Machleidt, W., Machleidt, Werner, Ghosh, Madhumita, Gil-Parrado, Shirley, Holak, Tad A., Joy, J., Joy, Joma, Holak, T. A., Jochum, Marianne, Popp, O., Nalabothula, N.   +15 more
core   +1 more source

Cyclin D1 goes metabolic [PDF]

Cell Cycle, 2012
Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
openaire   +2 more sources

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neosplasms [PDF]

, 2020
Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored.
Albero, Robert, Martín-Subero, José Ignacio, Beà Bobet, Sílvia M., Karube, Kennosuke, Jares Gerboles, Pedro, López-Guerra, Mónica, Campo Güerri, Elias, Demajo, Santiago, García, Noelia, Suárez-Cisneros, Helena, Colomer Pujol, Dolors, Pinyol, Magda, Capdevila, Cristina, Clot Razquin, Guillem, Castellano, Giancarlo, Shimada, Mariko, Enjuanes, Anna   +16 more
core   +2 more sources

The extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim, Dondu Nergiz, Canan Sadullahoglu, Zelal Akgunduz, Senay Yildirim, Selen Dogan, Cem Sezer   +6 more
doaj   +1 more source

Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer

Current Issues in Molecular Biology, 2022
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha   +7 more
doaj   +1 more source

Histone deacetylase inhibitor, Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells

Molecular Cancer, 2006
Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R, Lam Eric, Stavropoulou Alexandra V, Alao John P, Vigushin David M   +4 more
doaj   +1 more source