Results 21 to 30 of about 259,083 (282)
Cyclin D1 and human neoplasia [PDF]
Molecular Pathology, 1998 Neoplasia is characterised by abnormal regulation of the cell cycle. Cyclin D1 is a protein derived from the PRAD1, CCND1 or bcl-1 gene on chromosome 11q13, which is involved in both normal regulation of the cell cycle and neoplasia. In the G1 (resting) phase of the cell cycle, cyclin D1 together with its cyclin dependent kinase (cdk) partner, is ...
R, Donnellan, R, Chetty
openaire +2 more sources
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. [PDF]
PLoS Pathogens, 2011 EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator of G1 to S phase progression, is tightly associated and aberrantly expressed in numerous human cancers ...
Abhik Saha +7 more
doaj +1 more source
BMC Complementary and Alternative Medicine, 2017 Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park +6 more
doaj +1 more source
Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase [PDF]
Molecular and Cellular Biology, 2003 The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest.
J Alan, Diehl +4 more
openaire +2 more sources
Cell Division, 2008 Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj +1 more source
Cyclin D1 goes metabolic [PDF]
Cell Cycle, 2012 Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
openaire +2 more sources
Molecular Cancer, 2006 Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R +4 more
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2020 Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim +6 more
doaj +1 more source
Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
Current Issues in Molecular Biology, 2022 TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go +7 more
doaj +1 more source
Galectin-3 and cyclin D1 expression in non-small cell lung cancer
Journal of Experimental & Clinical Cancer Research, 2011 Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin +4 more
doaj +1 more source