Results 11 to 20 of about 240,615 (263)
Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer [PDF]
Advanced scienceCyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Alexandrou S +17 more
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Cyclin E, a redundant cyclin in breast cancer [PDF]
Proceedings of the National Academy of Sciences, 1996 Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in ...
J, Gray-Bablin +5 more
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Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas
Archives of Pathology & Laboratory Medicine, 2000 Abstract Background. —Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the ...
K, Allan +4 more
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Cells, 2019 The deubiquitinase DUB3 is frequently overexpressed in non-small cell lung cancer (NSCLC) and contributes to its malignant phenotype. However, the underlying molecular mechanism of DUB3 in NSCLC is largely unknown.
Bin Hu +12 more
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The crystal structure of cyclin A [PDF]
Structure, 1995 Background: Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
NR Brown +8 more
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iScience, 2020 Summary: Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth.
Xian-Feng Wang +8 more
doaj +1 more source
The 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cells. [PDF]
PLoS ONE, 2013 Antimitotic agents are frequently used to treat solid tumors and hematologic malignancies. However, one major limitation of antimitotic approaches is mitotic slippage, which is driven by slow degradation of cyclin B during a mitotic block.
Dominik Schnerch +4 more
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PTBP1 promotes IRES-mediated translation of cyclin B1in cancer
Acta Biochimica et Biophysica Sinica, 2022 Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition. Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.
Fan Xinyi +5 more
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Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K. Teixeira
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Determinants of human cyclin B1 association with mitotic chromosomes. [PDF]
PLoS ONE, 2013 Cyclin B1-CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several compartments of a mitotic cell ...
Kathleen L Pfaff, Randall W King
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