Results 31 to 40 of about 406,416 (358)
Meiotic progression in arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM [PDF]
, 2010 International audienceMeiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation.
Bulankova, Petra +4 more
core +3 more sources
Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas
Archives of Pathology & Laboratory Medicine, 2000 AbstractBackground.—Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the grades of malignancy.
K, Allan +4 more
openaire +2 more sources
médecine/sciences, 1993 La cycline A, associee a la proteine kinase p34 cdc2 , est impliquee dans la transition G2/M du cycle. Elle s'associe aussi a la proteine kinase p33 cdk2 au cours de la phase S du cycle. La cycline A participe a la formation de complexes multimeriques comprenant le facteur de transcription E2F, la proteine kinase p33 cdk2 et la proteine p107 ...
E. Lamas +7 more
openaire +1 more source
Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
BMC Research Notes, 2011 Background The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation ...
Yu Wendong +2 more
doaj +1 more source
The crystal structure of cyclin A [PDF]
Structure, 1995 Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
Brown NR +8 more
openaire +3 more sources
Viruses, 2016 The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber +9 more
doaj +1 more source
Translational Oncology, 2023 Background: The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination.
Yue Xiao +8 more
doaj +1 more source
Cyclin-dependent kinases: a family portrait [PDF]
Nature Cell Biology, 2009 To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Marcos, Malumbres +8 more
openaire +2 more sources
Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S. +4 more
core +4 more sources
Consequence of the tumor‐associated conversion to cyclin D1b
EMBO Molecular Medicine, 2015 Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to
Michael A Augello +12 more
doaj +1 more source