Results 101 to 110 of about 892,112 (398)

Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]

Journal of Chemical Information and Modeling, 2018, 2018
Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv   +1 more source

Characterization of the Human Cyclin-dependent Kinase 2 Gene [PDF]

Journal of Biological Chemistry, 1996
Cyclin-dependent kinase 2 is a serine/threonine protein kinase essential for progression of the mammalian cell cycle from G1 to S phase. CDK2 mRNA has been shown to be induced by serum in several cultured cell types. Therefore, we set out to identify elements that regulate the transcription of the human CDK2 gene and to characterize its structure. This
Christine S. Chan, Alan R. Brooks, Dov Shiffman, Peter G. Milner, Eric E. Brooks   +4 more
openaire   +3 more sources

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]

arXiv, 2022
The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv  

Identification and characterization of an irreversible inhibitor of CDK2 [PDF]

, 2015
Irreversible inhibitors that modify cysteine or lysine residues within a protein kinase ATP binding site offer, through their distinctive mode of action, an alternative to ATP-competitive agents.
Anscombe, Elizabeth, Cano, Celine, Danielson, U Helena, Endicott, Jane A, Geitmann, Matthis, Golding, Bernard T, Griffin, Roger J, Martin, Mathew P, Meschini, Elisa, Mora-Vidal, Regina, Newell, David R, Noble, Martin E M, Reuillon, Tristan, Stanley, Will A, Staunton, David, Wang, Lan Z, Wedge, Stephen R   +16 more
core   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Anticancer activity of Elsholtzia winitiana var. dongvanensis Phuong on gastric cancer cells: phytochemical profiling, cell proliferation inhibition, senescence induction, and cell cycle arrest

Beni-Suef University Journal of Basic and Applied Sciences
Background Elsholtzia, a genus within the Lamiaceae family, comprises 42 species predominantly distributed across East and Southeast Asia. Elsholtzia winitiana var. dongvanensis Phuong (EWD) is a subspecies of Elsholtzia winitiana endemic to the Dong Van–
Van Hung Hoang, Thi Thanh Huong Le, Phu Hung Nguyen, Duy Hung Nguyen, Quang Tan Luc, Thi Kieu Oanh Nguyen, Khac Hung Do   +6 more
doaj   +1 more source

A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit. [PDF]

PLoS ONE, 2007
In Schizosaccharomyces pombe, the nuclear-localized kinase, Lsk1p, promotes cytokinesis by positively regulating the Septation Initiation Network (SIN).
Jim Karagiannis, Mohan K Balasubramanian
doaj   +1 more source

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2 [PDF]

Genes & Development, 32:1-15, 2018, 2019
Saccharomyces cerevisiae target of rapamycin (TOR) complex 2 (TORC2) is an essential regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is modulated in response to changes in the status of the cell envelope is unclear. Here we document that TORC2 subunit Avo2 is a direct target of Slt2, the mitogen-activated protein kinase ...
arxiv   +1 more source

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells [PDF]

Current Biology, 1999
Centrosome duplication is indispensable for the formation of the bipolar mitotic spindle. Surprisingly, even if DNA replication or mitosis is inhibited, centrosome duplication can still occur [1] [2] [3] [4] [5]. Thus, it remains unknown how centrosome duplication is coordinated with the cell cycle.
Ken Hayashi, Eisuke Nishida, Yutaka Matsumoto   +2 more
openaire   +3 more sources