Results 141 to 150 of about 152,744 (302)

The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca²⁺/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner [PDF]

, 2002
Rani Dhavan, Paul L. Greer, Maria A. Morabito, Lianna Orlando, Li‐Huei Tsai   +4 more
openalex   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313. [PDF]

Acta Crystallogr F Struct Biol Commun, 2020
Talapati SR, Nataraj V, Pothuganti M, Gore S, Ramachandra M, Antony T, More SS, Krishnamurthy NR.   +7 more
europepmc   +1 more source

Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3β but not of cyclin-dependent kinase 5 and c-Jun NH ₂ -terminal kinase and concomitantly abolishes hyperphosphorylation of τ: Implications for Alzheimer's disease [PDF]

, 2002
Sozos Ch. Papasozomenos, A. Shanavas
openalex   +1 more source

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source

Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†. [PDF]

Biol Reprod, 2020
Faber EB, Wang N, Georg GI.
europepmc   +1 more source

Cyclooxygenase-2 Overexpression Inhibits Platelet-derived Growth Factor-induced Mesangial Cell Proliferation through Induction of the Tumor Suppressor Gene p53 and the Cyclin-dependent Kinase Inhibitors p21waf-1/cip-1 and p27kip-1 [PDF]

, 2002
Gunther Zahner, Günter Wolf, Murwan Ayoub, Rüdiger Reinking, Ulf Panzer, Stuart J. Shankland, Rolf A.K. Stahl   +6 more
openalex   +1 more source

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Cyclin-Dependent Kinase-2 Controls Oligodendrocyte Progenitor Cell Cycle Progression and Is Downregulated in Adult Oligodendrocyte Progenitors [PDF]

, 2002
Shibeshih Belachew, Adán Aguirre, Hang Wang, François Vautier, Xiaoqing Yuan, Stacie M. Anderson, Martha Kirby, Vittorio Gallo   +7 more
openalex   +1 more source

Real‐world treatment patterns among patients diagnosed with hormone receptor‐positive metastatic breast cancer in the USA

British Journal of Clinical Pharmacology, EarlyView.
Aims Clinical guidelines for breast cancer management have evolved in the past decade. However, limited evidence exists regarding uptake of novel drug classes in management of hormone receptor‐positive (HR+) metastatic breast cancer (MBC) in the USA and whether disparities exist by race and ethnicity.
Kexin Zhu, Coral O. Omene, Antoinette Stroup, Elisa V. Bandera, Farzin Khosrow‐Khavar   +4 more
wiley   +1 more source