Results 161 to 170 of about 152,744 (302)

Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. [PDF]

J Biol Chem, 2020
Xia P, Chen J, Liu Y, Fletcher M, Jensen BC, Cheng Z.   +5 more
europepmc   +1 more source

Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G ₁ Transit via a Src Kinase Pathway

, 2001
Michael J. Bouchard, Stavros Giannakopoulos, Edith H. Wang, Naoko Tanese, Robert J. Schneider   +4 more
openalex   +1 more source

Indole-3-Carbinol (I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and Subcellular Localization of the CDK2 Protein Complex [PDF]

, 2004
Hanh H. Garcia, Gloria A. Brar, David H.H. Nguyen, Leonard F. Bjeldanes, Gary L. Firestone   +4 more
openalex   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source

The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation

, 2001
Lüder Wiebusch
openalex   +2 more sources

Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells [PDF]

, 2004
Richard M. Harwell, Benjamin B. Mull, Donald C. Porter, Khandan Keyomarsi   +3 more
openalex   +1 more source

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights. [PDF]

J Enzyme Inhib Med Chem, 2020
Sabt A, Eldehna WM, Al-Warhi T, Alotaibi OJ, Elaasser MM, Suliman H, Abdel-Aziz HA.   +6 more
europepmc   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Retinoblastoma Tumor Suppressor Protein Signals through Inhibition of Cyclin-Dependent Kinase 2 Activity To Disrupt PCNA Function in S Phase

, 2001
Zvjezdana Sever-Chroneos, Steven P. Angus, Anne F. Fribourg, Huajing Wan, Иван Тодоров, Karen E. Knudsen, Erik S. Knudsen   +6 more
openalex   +1 more source

α2-Chimaerin, Cyclin-Dependent Kinase 5/p35, and Its Target Collapsin Response Mediator Protein-2 Are Essential Components in Semaphorin 3A-Induced Growth-Cone Collapse [PDF]

, 2004
Matthew Brown, Tom Jacobs, Britta J. Eickholt, Giovanna Ferrari, Mabel Teo, Clinton Monfries, Robert Z. Qi, Thomas Leung, Louis Lim, Christine M Hall   +9 more
openalex   +1 more source