Results 161 to 170 of about 161,781 (188)

Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase. [PDF]

Science
Cushing VI, McGeoch AJS, Williams SL, Roumeliotis TI, Feng J, Dan LM, Choudhary JS, Davey NE, Greber BJ.   +8 more
europepmc   +1 more source

Targeting cell cycle in leukemia: "Is palbociclib the game-changer?": A review. [PDF]

Medicine (Baltimore)
Azizan MA, Abeden Z, Shamsuddin NHN, Ahid F, Mohd Yusoff N, Ismail MN, Ng SK, Isa A.   +7 more
europepmc   +1 more source

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2-Aminoquinazoline inhibitors of cyclin-dependent kinases

Bioorganic & Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Yadagiri, Bathini, Inderjit, Singh, Patricia J, Harvey, Paul R, Keller, Rajeshwar, Singh, Ronald G, Micetich, David W, Fry, Ellen M, Dobrusin, Peter L, Toogood   +8 more
openaire   +2 more sources

Crystal structure of cyclin-dependent kinase 2

Nature, 1993
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution.
H L, De Bondt, J, Rosenblatt, J, Jancarik, H D, Jones, D O, Morgan, S H, Kim   +5 more
openaire   +2 more sources

Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity

Journal of Medicinal Chemistry, 2006
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues,
Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM   +5 more
openaire   +3 more sources

Inhibitors of Cyclin-Dependent Kinase 1/2 for Anticancer Treatment

Medicinal Chemistry, 2020
Background: The cell cycle is regulated by cyclin-dependent kinases (CDKs) and their cognate cyclins, along with their endogenous inhibitors (CDKIs). CDKs act as central regulators in this process. Different CDKs play relevant roles in different phases.
Jiajia, Mou, Danghui, Chen, Yanru, Deng
openaire   +2 more sources

When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2

Journal of Medical Virology, 2022
AbstractCyclin‐dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning CDKs' roles in viral infection and host antiviral defense are unknown.
Yan Yan, Yan‐dong Tang, Chunfu Zheng
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Purification and Crystallization of Human Cyclin-dependent Kinase 2

Journal of Molecular Biology, 1993
The major transitions of the eukaryotic cell cycle are triggered by cyclin-dependent protein kinases. We report the purification and crystallization of the catalytic subunit of human cyclin-dependent kinase 2 (CDK2), which has been implicated in the control of the G1/S transition.
J, Rosenblatt, H, De Bondt, J, Jancarik, D O, Morgan, S H, Kim   +4 more
openaire   +2 more sources

Regulation of Cyclin-Dependent Kinase 2 Activity by Ceramide

Experimental Cell Research, 2000
Cyclin-dependent kinases have been implicated in the inactivation of retinoblastoma (Rb) protein and cell cycle progression. Recent studies have demonstrated that the lipid molecule ceramide is able to induce Rb hypophosphorylation leading to growth arrest and cellular senescence.
J Y, Lee, A E, Bielawska, L M, Obeid
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A flavonoid gossypin binds to cyclin-dependent kinase 2

Bioorganic & Medicinal Chemistry Letters, 2008
Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR ...
Hojung, Kim, Eunjung, Lee, Jihye, Kim, Bora, Jung, Youhoon, Chong, Joong-Hoon, Ahn, Yoongho, Lim   +6 more
openaire   +2 more sources