Results 181 to 190 of about 543,132 (243)

Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH₂-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease [PDF]

, 2009
Kai-Hui Sun, Hyoung‐gon Lee, Mark A. Smith, Kavita Shah   +3 more
openalex   +1 more source

Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD?

International Journal of Cancer, EarlyView.
What's New? Currently, no published data on homologous recombination deficiency (HRD) testing in the setting of molecular tumor boards exist. This study in a cohort of 237 patients encompassing 24 different tumor entities assessed by a molecular tumor board shows that inactivating alterations of BRCA1/2 are not always associated with an elevated ...
Christoph Schubart, Lars Tögel, Maria Giulia Carta, Philip Hetzner, Lina Helbig, Charlotte Zaglas, Maria Ziegler, Robert Stöhr, Annett Hölsken, Juliane Hoyer, Fulvia Ferrazzi, Clemens Neufert, Sebastian Lettmaier, Marianne Pavel, Henriette Golcher, Sarina K. Mueller, Florian Fuchs, Carla E. Schulmeyer, Matthias W. Beckmann, Bernd Wullich, Abbas Agaimy, Andre Reis, Arndt Hartmann, Norbert Meidenbauer, Silvia Spoerl, Florian Haller, Evgeny A. Moskalev   +26 more
wiley   +1 more source

Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9 [PDF]

, 2010
Zufan Debebe, Tatiana Ammosova, Denitra Breuer, David B. Lovejoy, Danuta S. Kalinowski, Pradeep K. Karla, K. A. Jeevan Kumar, Marina Jerebtsova, Patricio E. Ray, Fatah Kashanchi, Victor R. Gordeuk, Des R. Richardson, Sergeï Nekhai   +12 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Cyclin dependent kinase 2 (CDK2); cyclin E (CCNE); HER2 (EGFR2; ERBB2; neu) [PDF]

, 2011

openalex   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

Candidate Biomarkers Associated With Circulating Tumor Cell Status in Metastatic Colorectal Cancer

Journal of Clinical Laboratory Analysis, Volume 39, Issue 7, April 2025.
This study investigates circulating miRNA signatures linked to the status of circulating tumor cells (CTC) in metastatic colorectal cancer (mCRC). Using AdnaTest ColonCancer technology and miRNA microarray analysis, we identified downregulated miRNAs associated with CTC status, including miR‐181c‐5p, miR‐199a‐5p, miR‐500b‐5p, and miR‐769‐5p.
Berkcan Doğan, Dilek Pirim, Özgen Işık, Türkkan Evrensel   +3 more
wiley   +1 more source

Ferulic acid: extraction, estimation, bioactivity and applications for human health and food

Journal of the Science of Food and Agriculture, Volume 105, Issue 8, Page 4168-4177, June 2025.
Abstract Ferulic acid ((E)‐3‐(4‐hydroxy‐3‐methoxy‐phenyl) prop‐2‐enoic acid) is a derivative of caffeic acid found in most plants. This abundant phenolic compound exhibits significant antioxidant capacity and a broad spectrum of therapeutic effects, including anti‐inflammatory, antimicrobial, anticancer, antidiabetic, cardiovascular and neuroprotective
Mukul Kumar, Deepika Kaushik, Shubham Shubham, Ashwani Kumar, Vishal Kumar, Emel Oz, Charles Brennan, Maomao Zeng, Charalampos Proestos, Kenan Çadırcı, Muharrem Bayrak, Tahra Elobeid, Sercan Karav, Fatih Oz   +13 more
wiley   +1 more source

Drug Design of Cyclin-Dependent Kinase 2 Inhibitor for Melanoma from Traditional Chinese Medicine [PDF]

, 2014
Hsin‐Chieh Tang, Calvin Yu‐Chian Chen   +1 more
openalex   +1 more source