Results 181 to 190 of about 152,744 (302)

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells

, 2002
Min‐Hsiung Pan
openalex   +1 more source

Interferon γ Induces Neurite Outgrowth by Up-regulation of p35 Neuron-specific Cyclin-dependent Kinase 5 Activator via Activation of ERK1/2 Pathway [PDF]

, 2005
Jin H. Song, Chen Xu Wang, Doyoun K. Song, Peng Wang, Ashfaq Shuaib, Chunhai Hao   +5 more
openalex   +1 more source

Synthesis, Molecular Docking, and Biological Studies of New Naphthalene‐1,4‐Dione‐Linked Phenylpiperazine and Thioether

Chemistry &Biodiversity, EarlyView.
Synthesis, Molecular Docking, and Biological Studies of New Naphthalene‐1,4‐dione Linked Phenylpiperazine and Thioether. ABSTRACT Quinones are an important family of chemical compounds that are used in the development of anticancer drugs. Due to the anticancer properties of quinones, this study aims to investigate the antiproliferative and ...
Berrin Yilmaz, Nahide Gulsah Deniz, Cigdem Sayil, Ozlem Bingol Ozakpinar, Merve Gurboga, Turgut Sekerler, Pervin Rayaman, Erkan Rayaman, Elif Caliskan Salihi   +8 more
wiley   +1 more source

Synthesis, docking, MD simulation, ADMET, drug likeness, and DFT studies of novel furo[2,3-b]indol-3a-ol as promising Cyclin-dependent kinase 2 inhibitors. [PDF]

Sci Rep
Gheidari D, Mehrdad M, Bayat M.
europepmc   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

ChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska, Jan Hendrik Illies, T. Moritz Weber   +2 more
wiley   +1 more source

Cyclin-Dependent Kinase 2/Cyclin E Complex Is Involved in p120 Catenin (p120ctn)–Dependent Cell Growth Control: A New Role for p120ctn in Cancer [PDF]

, 2007
Nicolas T. Chartier, Christiane Oddou, Michèle G. Lainé, Benjamin Ducarouge, Christiane Marie, Marc R. Block, Muriel R. Jacquier‐Sarlin   +6 more
openalex   +1 more source

Macromolecular High‐Affinity Binding Probed by Advanced Fluorescence Techniques

ChemBioChem, EarlyView.
For interacting biomolecules in solution, confocal fluorescence microscopy enables some very effective approaches to characterize intermolecular binding in complex sample environments and with small sample consumption. These approaches range from fluorescence‐based genetically encoded biosensors for use in living cells to the high controllability in ...
Alida Meyer, Benno Schedler, Jörg Fitter   +2 more
wiley   +1 more source

Mechanistic insights into the phosphoryl transfer reaction in cyclin-dependent kinase 2: A QM/MM study. [PDF]

PLoS One, 2019
Recabarren R, Osorio EH, Caballero J, Tuñón I, Alzate-Morales JH.   +4 more
europepmc   +1 more source

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Cancer Communications, EarlyView.
Monika Raab, Balázs Győrffy, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt   +10 more
wiley   +1 more source