Results 11 to 20 of about 152,744 (302)
Cyclin-dependent kinase 2 controls peripheral immune tolerance. [PDF]
J Immunol, 2012 Abstract Adaptive immunity requires signals from both the TCR and the costimulatory molecule CD28. These receptors activate multiple signaling pathways, including the cyclin-dependent kinase (CDK) cascade, and antigenic signals in the absence of costimulation result in a tolerant state that is enforced by the CDK inhibitory protein ...
Chunder N +4 more
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COMPUTATIONAL STUDY OF THE INTERACTION BETWEEN INDENE PYRAZOLE AND CYCLIN DEPENDENT KINASE 2
Química Nova, 2017 Proteins have been traditionally out of reach of electronic structure methods. But with technological advances in the development of powerful computers and the need to extend the methods of computational chemistry to problems of biological interest, such
Juan Enrique Torres +4 more
doaj +4 more sources
Role for cyclin-dependent kinase 2 in mitosis exit [PDF]
Current Biology, 2001 Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity [1]. Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B [2]. Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable [5]. At the end of mitosis, downregulation of cdk2-cyclin
Vincenzo D’Angiolella +5 more
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Cyclin-dependent Kinase 2 Nucleocytoplasmic Translocation Is Regulated by Extracellular Regulated Kinase [PDF]
Journal of Biological Chemistry, 2001 Activation of cyclin-dependent kinase 2 (CDK2)-cyclin E in the late G(1) phase of the cell cycle is important for transit into S phase. In Chinese hamster embryonic fibroblasts (IIC9) phosphatidylinositol 3-kinase and ERK regulate alpha-thrombin-induced G(1) transit by their effects on cyclin D1 protein accumulation (Phillips-Mason, P. J., Raben, D. M.,
Susan M. Keenan +2 more
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Molecular Motions of Human Cyclin-dependent Kinase 2 [PDF]
Journal of Biological Chemistry, 2005 We present a comprehensive description of the dynamic behavior of CDK2 in complex with cyclin A, arrived at by analysis of a total of 0.25 micros of solvated molecular dynamics trajectories and 42 deposited CDK2 structures, and refined using other protein simulation algorithms. The CDK2-cyclin A dimer is a dynamic complex of 6 subdomains.
C. Paul Barrett, M.E.M. Noble
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Modulation of β-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2 [PDF]
Journal of Biological Chemistry, 2004 beta-Catenin functions as a downstream component of the Wnt/Wingless signal transduction pathway, and inappropriate control of cytosolic beta-catenin is a crucial step in the genesis of several human cancers. Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in
Chun Shik Park +6 more
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Cyclin-dependent kinase 2 protects podocytes from apoptosis. [PDF]
Sci Rep, 2016 AbstractLoss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of DN, downregulated CDK2 (cyclin-dependent kinase 2). LPS-treatment of mice also
Saurus P +10 more
europepmc +8 more sources
Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding [PDF]
Biochemical and Biophysical Research Communications, 2008 The cyclin-dependent kinase CDK2 is inactivated by phosphorylation on either of the two neighbouring residues Thr14 or Tyr15. The effect of phosphorylation on metal ion binding has been investigated with peptides incorporating residues 6-20 of CDK2. The stoichiometry of Ca(2+) binding increased from 1 in the un- and singly-phosphorylated peptides to 2 ...
Graham S. Baldwin
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CDK2 (cyclin dependent kinase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on CDK2, with data on DNA, on the protein encoded, and where the gene is implicated.
Wingren, Anette Gjörloff +1 more
openaire +3 more sources
Foxp3 protein stability is regulated by cyclin-dependent kinase 2. [PDF]
J Biol Chem, 2013 Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and inflammatory disease. Expression of Foxp3 is necessary for the anti-inflammatory capacity of Treg, but whether Foxp3 activity is further subject to regulation by extracellular
Morawski PA +4 more
europepmc +5 more sources