Results 11 to 20 of about 684,735 (325)

Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. [PDF]

Mol Med Rep, 2015
Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallmark of cancer. The present study was the first to use idock, a free and open‑source protein‑ligand docking software developed by our group, to identify ...
Shi XN, Li H, Yao H, Liu X, Li L, Leung KS, Kung HF, Lin MC.   +7 more
europepmc   +5 more sources

Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding [PDF]

Biochemical and Biophysical Research Communications, 2008
The cyclin-dependent kinase CDK2 is inactivated by phosphorylation on either of the two neighbouring residues Thr14 or Tyr15. The effect of phosphorylation on metal ion binding has been investigated with peptides incorporating residues 6-20 of CDK2. The stoichiometry of Ca(2+) binding increased from 1 in the un- and singly-phosphorylated peptides to 2 ...
Graham S. Baldwin
openalex   +4 more sources

COMPUTATIONAL STUDY OF THE INTERACTION BETWEEN INDENE PYRAZOLE AND CYCLIN DEPENDENT KINASE 2

Química Nova, 2017
Proteins have been traditionally out of reach of electronic structure methods. But with technological advances in the development of powerful computers and the need to extend the methods of computational chemistry to problems of biological interest, such
Juan Enrique Torres, Juan Pablo Toro, Javier Vergara, Rosa Baldiris, Ricardo Vivas Reyes   +4 more
doaj   +4 more sources

Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. [PDF]

Cancer Sci, 2019
Hepatocellular carcinoma (HCC) is a common and aggressive malignant tumor with a poorly defined molecular mechanism. Cyclin‐dependent kinase 2 (CDK2) and Septin2 (SEPT2) are 2 known oncogenic molecules but the mechanism of functional interactions remains unclear.
Xu C, Zhang W, Zhang X, Zhou D, Qu L, Liu J, Xiao M, Ni R, Jiang F, Ni W, Lu C.   +10 more
europepmc   +5 more sources

A Simple and Efficient Docking Method to the Cyclin-Dependent Kinase 2 [PDF]

Bulletin of the Korean Chemical Society, 2007
The subtle but significant differences and thereby the lack of consensus in active site structures among the crystal structures of cyclin-dependent kinase 2 (CDK2) has hampered structure-based drug design. In this study, we devised a simple but effective ‘mutation, pharmacophore-guided docking, followed by mutation' strategy to generate an “average ...
Kwang‐Su Park, Jinyoung Kim, Youhoon Chong, Hyunah Choo   +3 more
openalex   +4 more sources

Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2 [PDF]

Bulletin of the Korean Chemical Society, 2007
Among several classes ofphenolic compounds, a group with the core structure of C6-C3-C6 is named flavonoids (benzo-γ-pyran derivatives),consisting of phenolic and pyran rings. According to theoxidation state of pyran ring, flavonoids can be furthersubdivided into five major subclasses as follows: flavonols,flavanols, flavones, isoflavones, and ...
Ho Jung Kim, Eunjung Lee, Jihye Kim, Kwang‐Su Park, Haeyoung Lim, Chul‐Hoon Lee, Joong-Hoon Ahn, Youhoon Chong, Yoongho Lim   +8 more
openalex   +4 more sources

Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2. [PDF]

Cell Cycle, 2014
Allosteric targeting of protein kinases via displacement of the structural αC helix with type III allosteric inhibitors is currently gaining a foothold in drug discovery. Recently, the first crystal structure of CDK2 with an open allosteric pocket adjacent to the αC helix has been described, prospecting new opportunities to design more selective ...
Rastelli G, Anighoro A, Chripkova M, Carrassa L, Broggini M.   +4 more
europepmc   +5 more sources

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

CDK2 (cyclin dependent kinase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on CDK2, with data on DNA, on the protein encoded, and where the gene is implicated.
Wingren, Anette Gjörloff, Nyesiga, Barnabas   +1 more
openaire   +3 more sources

ASSOCIATION OF RS2069502 CYCLIN-DEPENDENT KINASE 4 GENE WITH BREAST CANCER [PDF]

Euromediterranean Biomedical Journal, 2020
The goal of this project was to evaluate the association of candidate genetic variant rs2069502 of the CDK4 gene with breast cancer and the effect of variant genotypes on the serum concentration of CDK4 enzyme and consequently, on the occurrence of ...
Dalya Shakir Al-owaidi
doaj   +1 more source