Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. [PDF]
Mol Med Rep, 2015 Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallmark of cancer. The present study was the first to use idock, a free and open‑source protein‑ligand docking software developed by our group, to identify ...
Shi XN +7 more
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CDK2 (cyclin dependent kinase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on CDK2, with data on DNA, on the protein encoded, and where the gene is implicated.
Wingren, Anette Gjörloff +1 more
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Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding [PDF]
Biochemical and Biophysical Research Communications, 2008 The cyclin-dependent kinase CDK2 is inactivated by phosphorylation on either of the two neighbouring residues Thr14 or Tyr15. The effect of phosphorylation on metal ion binding has been investigated with peptides incorporating residues 6-20 of CDK2. The stoichiometry of Ca(2+) binding increased from 1 in the un- and singly-phosphorylated peptides to 2 ...
Graham S. Baldwin
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COMPUTATIONAL STUDY OF THE INTERACTION BETWEEN INDENE PYRAZOLE AND CYCLIN DEPENDENT KINASE 2
Química Nova, 2017 Proteins have been traditionally out of reach of electronic structure methods. But with technological advances in the development of powerful computers and the need to extend the methods of computational chemistry to problems of biological interest, such
Juan Enrique Torres +4 more
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A Simple and Efficient Docking Method to the Cyclin-Dependent Kinase 2 [PDF]
Bulletin of the Korean Chemical Society, 2007 The subtle but significant differences and thereby the lack of consensus in active site structures among the crystal structures of cyclin-dependent kinase 2 (CDK2) has hampered structure-based drug design. In this study, we devised a simple but effective ‘mutation, pharmacophore-guided docking, followed by mutation' strategy to generate an “average ...
Kwang‐Su Park +3 more
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Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. [PDF]
Cancer Sci, 2019 Hepatocellular carcinoma (HCC) is a common and aggressive malignant tumor with a poorly defined molecular mechanism. Cyclin‐dependent kinase 2 (CDK2) and Septin2 (SEPT2) are 2 known oncogenic molecules but the mechanism of functional interactions remains unclear.
Xu C +10 more
europepmc +5 more sources
Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2 [PDF]
Bulletin of the Korean Chemical Society, 2007 Among several classes ofphenolic compounds, a group with the core structure of C6-C3-C6 is named flavonoids (benzo-γ-pyran derivatives),consisting of phenolic and pyran rings. According to theoxidation state of pyran ring, flavonoids can be furthersubdivided into five major subclasses as follows: flavonols,flavanols, flavones, isoflavones, and ...
Ho Jung Kim +8 more
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Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity [PDF]
Journal of Biological Chemistry, 1999 We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) for crystallization using the CDK-activating kinase 1 (CAK1) from Saccharomyces cerevisiae and have grown crystals using microseeding techniques. Phosphorylation of monomeric human CDK2 by CAK1 is more efficient than phosphorylation of the binary CDK2-cyclin A complex ...
Brown, Nicholas +7 more
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Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†. [PDF]
Biol Reprod, 2020 Cyclin-dependent kinase 2 (CDK2) is a member of the larger cell cycle regulating CDK family of kinases, activated by binding partner cyclins as its name suggests.
Faber EB, Wang N, Georg GI.
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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation [PDF]
Cell Division, 2012 Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle ...
Caillava Céline +1 more
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