Results 11 to 20 of about 161,781 (188)

PAK4 phosphorylates cyclin-dependent kinase 2 to promote the G1/S transition during adipogenesis [PDF]

Experimental and Molecular Medicine
p21-activated kinase 4 (PAK4), a member of the PAK family (PAK1–6), was initially recognized for its role in tumor development. Recently, we discovered PAK4’s involvement in triacylglycerol lipolysis in adipocytes.
Hwang Chan Yu, Su Hyeon Park, Hye Jin Jo, Hyunchae Sim, Mi Rin Lee, Gahee Kim, So-Young Park, Yoonji Lee, Eun Ju Bae, Byung-Hyun Park   +9 more
doaj   +2 more sources

Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiaoyuan Li, Ping Huang, Jingrong Jean Cui, Jennifer Zhang, Cho Tang   +4 more
openalex   +4 more sources

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

CDK2 (cyclin dependent kinase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on CDK2, with data on DNA, on the protein encoded, and where the gene is implicated.
Wingren, Anette Gjörloff, Nyesiga, Barnabas   +1 more
openaire   +2 more sources

ASSOCIATION OF RS2069502 CYCLIN-DEPENDENT KINASE 4 GENE WITH BREAST CANCER [PDF]

Euromediterranean Biomedical Journal, 2020
The goal of this project was to evaluate the association of candidate genetic variant rs2069502 of the CDK4 gene with breast cancer and the effect of variant genotypes on the serum concentration of CDK4 enzyme and consequently, on the occurrence of ...
Dalya Shakir Al-owaidi
doaj   +1 more source

Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

Acta Pharmaceutica Sinica B, 2022
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this ...
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung   +12 more
doaj   +1 more source

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

PLoS ONE, 2023
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in ...
Anna McGriff, William J Placzek
doaj   +1 more source

Study of cytostatic and cytotoxic characteristics of modified peptide CDK4/6 inhibitors – functional analogs of p16INK4a (90-97)

Успехи молекулярной онкологии, 2021
Background. Application of mathematical modeling for search for biologically active molecules is currently a promising scientific approach. Application of numerical algorithms for optimization of peptide sequences and molecular dynamics allowed to obtain
V. K. Bozhenko, T. M. Kulinich, E. A. Kudinova, A. V. Ivanov, A. M. Shishkin, V. A. Solodkiy   +5 more
doaj   +1 more source

Molecular Motions of Human Cyclin-dependent Kinase 2 [PDF]

Journal of Biological Chemistry, 2005
We present a comprehensive description of the dynamic behavior of CDK2 in complex with cyclin A, arrived at by analysis of a total of 0.25 micros of solvated molecular dynamics trajectories and 42 deposited CDK2 structures, and refined using other protein simulation algorithms. The CDK2-cyclin A dimer is a dynamic complex of 6 subdomains.
C Paul, Barrett, Martin E M, Noble
openaire   +2 more sources

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Journal of Translational Medicine, 2021
Background Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu   +6 more
doaj   +1 more source