Results 201 to 210 of about 543,132 (243)

Liposome‐Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6‐Bromo‐Indirubin‐3′‐Oxime Enable the Treatment of Refractive Melanoma

Small, EarlyView.
Cancer cells are exposed to heightened levels of endoplasmic reticulum stress and inflammation within the tumor microenvironment which can lead to therapeutic resistance. To address this issue, liposome‐polymer nanoparticles loaded with copper diethyldithiocarbamate (CuET), a potent inhibitor of the p97‐UFD1‐NPL4 protein complex, and the anti ...
Radu A. Paun, Ling Li, Adam Mouncef, Danuta Radzioch, Maryam Tabrizian   +4 more
wiley   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Cyclin-Dependent Kinase 2 Controls Peripheral Immune Tolerance

, 2012
Neelanjana Chunder, Liqing Wang, Chunxia Chen, Wayne W. Hancock, Andrew D. Wells   +4 more
openalex   +1 more source

Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives

VIEW, EarlyView.
In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J. Saladin, Youlan Lei, Weibo Cai, Lei Kang   +6 more
wiley   +1 more source

Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

, 2012
Dai Horiuchi, Noelle E. Huskey, Leonard Kusdra, Lara Wohlbold, Karl A. Merrick, Chao Zhang, Katelyn J. Creasman, Kevan M. Shokat, Robert P. Fisher, Andrei Goga   +9 more
openalex   +1 more source

Extended longevity of termite kings and queens is accompanied by extranuclear localization of telomerase in somatic organs and caste‐specific expression of its isoforms

Insect Science, Volume 32, Issue 2, Page 364-384, April 2025.
We recently reported that long‐lived termite kings and queens display an increased enzymatic activity and abundance of telomerase in their soma when compared to short‐lived workers. We hypothesized that this telomerase activation may represent its noncanonical pro‐longevity function, independent of its canonical role in telomere maintenance.
Marie Pangrácová, Jan Křivánek, Markéta Vrchotová, Hana Sehadová, Romana Hadravová, Robert Hanus, Ondřej Lukšan   +6 more
wiley   +1 more source

Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer

, 2013
Mei Sun, Rui Jiang, Guan Wang, Chao Zhang, Jindong Li, Chengyan Jin, Xingyi Zhang   +6 more
openalex   +2 more sources

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Nuclear respiratory factor‐1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells

Aging Cell, Volume 24, Issue 4, April 2025.
Mitochondrial dysfunction is associated with senescence, the latter proving detrimental to mesenchymal stem cell (MSC)‐based strategies. We induced the expression of nuclear respiratory factor‐1 (NRF1), a driver of mitochondrial biogenesis, to metabolically potentiate MSCs and stave off senescence.
Hyunho Lee, Matteo Massaro, Nourhan Abdelfattah, Gherardo Baudo, Haoran Liu, Kyuson Yun, Elvin Blanco   +6 more
wiley   +1 more source