Results 211 to 220 of about 543,132 (243)

Expression of p27(Kip1), a Cyclin-Dependent Kinase Inhibitor, in Human Peripheral Blood Mononuclear Cells Is Inversely Associated with Potential Carcinogenic Risk in Obese Type 2 Diabetic Individuals Relative to Lean Normal Controls

, 2014
Isao Eto
openalex   +2 more sources

Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast

Aging Cell, Volume 24, Issue 4, April 2025.
Extender of chronological lifespan 1 (Ecl1), which inhibits the target of rapamycin complex 1 (TORC1), physically interacts with TORC1 subunits and is necessary for appropriate cellular responses to various stressors, such as starvation, in fission yeast. Several functions of Ecl1 are suppressed by Thr7 phosphorylation when nutrients are abundant.
Hokuto Ohtsuka, Sawa Kawai, Yurika Ito, Yuka Kato, Takafumi Shimasaki, Kazuki Imada, Yoko Otsubo, Akira Yamashita, Emi Mishiro‐Sato, Keiko Kuwata, Hirofumi Aiba   +10 more
wiley   +1 more source

Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

, 2015
Raj N. Misra, Hai-yun Xiao, Kyoung S. Kim, Songfeng Lu, Wen-Ching Han, Stephanie A. Barbosa, John T. Hunt, David B. Rawlins, Weifang Shan, Syed Z. Ahmed, Ligang Qian, Bang-Chi Chen, Rui-Lin Zhao, Mark S. Bednarz, Kristen A. Kellar, Janet G. Mulheron, Roberta S. Batorsky, Urvashi V. Roongta, Amrita V. Kamath, Punit Marathe, Sunanda A. Ranadive, John S. Sack, John S. Tokarski, Nikola P. Pavletich, Francis Y. F. Lee, Kevin R. Webster, S. David Kimball   +26 more
openalex   +1 more source

Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human‐Induced Pluripotent Stem Cells

Aging Cell, Volume 24, Issue 5, May 2025.
We created an inducible system to control the expression of p16, and found that tau phosphorylation was enhanced upon p16 up‐regulation in neurons differentiated from human iPSCs. As p16 expression is increased during aging, our findings suggest a possible role of age‐associated p16 up‐regulation in Alzheimer's disease. As pathological tau tangles have
Kristopher Holloway, Kashfia Neherin, Yingduo Song, Kazuhito Sato, Andrew Houston, Feng Chen, Li Ding, Hong Zhang   +7 more
wiley   +1 more source

Low‐Intensity Pulsed Ultrasound Treatment Selectively Stimulates Senescent Cells to Promote SASP Factors for Immune Cell Recruitment

Aging Cell, Volume 24, Issue 5, May 2025.
The regulatory effects of low‐intensity pulsed ultrasound (LIPUS) stimulation in senescent cells are presented. LIPUS perturbs the membrane in senescent cells and induces intracellular reactive oxygen species via NOX4 expression. Consequently, secretion of senescence‐associated secretory phenotype, followed by migration of monocytes/macrophages and ...
HyeRan Gwak, Seoyoung Hong, Su Hyun Lee, In Woo Kim, Yonghan Kim, Hyungmin Kim, Ki Joo Pahk, So Yeon Kim   +7 more
wiley   +1 more source

Targeting CRM1 for Progeria Syndrome Therapy

Aging Cell, Volume 24, Issue 5, May 2025.
Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce, Marlon De Ita, Susana Castro‐Obregón, Diego Cortez, Yosef Landesman, Jonathan J. Magaña, Susana Gonzalo, Tania Zavaleta, Angelica Soberano‐Nieto, Juan Unzueta, Isabel Arrieta‐Cruz, Porfirio Nava, Aurora Candelario‐Martínez, Ian García‐Aguirre, Bulmaro Cisneros   +14 more
wiley   +1 more source

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound

Aging Cell, EarlyView.
Optimized low‐frequency ultrasound rejuvenates induced senescent cells and aged mice. Our results show that LFU reverses 15 aspects of senescent cells including growth and revitalizes aged mice. ABSTRACT The presence of senescent cells causes age‐related pathologies since their removal by genetic or pharmacological means, as well as possibly by ...
Sanjay K. Kureel, Rosario Maroto, Maisha Aniqua, Simon Powell, Ekta Singh, Felix Margadant, Brandon Blair, Blake B. Rasmussen, Michael P. Sheetz   +8 more
wiley   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence

Aging Cell, Volume 24, Issue 4, April 2025.
Senescence inducing stimuli leads to large‐cluster hypercondensed DNA globules. This architectural phenomenon is associated with geographically clustered transcriptional repression. Such large‐scale clustered silencing of chromosomal segments may drive deep senescence through two possible ways: (1) one or more critical combination of genes, for example
Aditi U. Gurkar, Satoshi Okawa, Christelle Guillermier, Kritika Chaddha, Matthew L. Steinhauser   +4 more
wiley   +1 more source

BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration

Aging Cell, EarlyView.
This study identifies BRD4 as a key regulator in intervertebral disk degeneration (IDD), linking its upregulation to NP cell senescence and disrupted ECM metabolism through the BRD4/MAP2K7/PGF signaling cascade, offering a potential therapeutic target for IDD treatment.
Guangzhi Zhang, Lei Li, Zhili Yang, Zhenyu Cao, Xuchang Hu, Yonggang Wang, Xuewen Kang   +6 more
wiley   +1 more source