Results 221 to 230 of about 152,744 (302)
Patient‐derived xenograft models in pan‐cancer: From bench to clinic
Interdisciplinary Medicine, EarlyView.Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li +5 more
wiley +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, EarlyView.Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
Cyclin-Dependent Kinase Inhibits Reinitiation of a Normal S-Phase Program during G2 in Fission Yeast
, 2009 Lee Kiang +4 more
openalex +1 more source
Med Research, EarlyView.The incidence and mortality of liver cancer remain consistently high worldwide, with China particularly affected. To identify potential therapeutic components and elucidate their mechanisms of action, this study performed a comprehensive multiomics analysis based on the active ingredients of LCL.
Zixuan Yang +5 more
wiley +1 more source
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression. [PDF]
Oncotarget, 2015 Yang L +8 more
europepmc +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, EarlyView.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2. [PDF]
J Biol Chem, 2015 Lin Y +9 more
europepmc +1 more source
Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment
Molecular Nutrition &Food Research, EarlyView.Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti +4 more
wiley +1 more source