Results 231 to 240 of about 152,744 (302)

Grape Seed Proanthocyanidins: A Potential Microbiome‐Targeted Intervention for Healthy Aging in Rats

Molecular Nutrition &Food Research, EarlyView.
Grape seed proanthocyanidin extract (GSPE) promotes a healthier gut phenotype in aged rats. Aging alters gut microbiota composition, increases inflammation, and compromises intestinal barrier function. This study shows that short‐term GSPE treatment in aged rats partially restores microbial diversity toward a youthful profile, modulates mucus‐related ...
Marta Sierra‐Cruz, Adrià Vilalta, Alba Miguéns‐Gómez, Harry Park, Esther Rodríguez‐Gallego, Maria Teresa Blay, Anna Ardévol, Montserrat Pinent, Jacques Behmoaras, Raúl Beltrán‐Debón, Ximena Terra   +10 more
wiley   +1 more source

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

ChemistryOpen, EarlyView.
Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi   +6 more
wiley   +1 more source

Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2. [PDF]

Cell Cycle, 2014
Rastelli G, Anighoro A, Chripkova M, Carrassa L, Broggini M.   +4 more
europepmc   +1 more source

Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer

, 2013
Mei Sun, Rui Jiang, Guan Wang, Chao Zhang, Jindong Li, Chengyan Jin, Xingyi Zhang   +6 more
openalex   +2 more sources

Salen‐Type Copper(II) Complexes: Synthesis, Characterization, Computational Studies, Molecular Docking, Anticancer Potential, and Pharmacokinetic Prediction

ChemistryOpen, EarlyView.
Integrating synthesis, density functional theory studies, molecular docking, cytotoxicity, and ADMET predictions, this study identifies [CuII(salen)(H2O)2] (2) as a selective anticancer agent. Docking and in vitro assays highlight its favorable target interactions, selective anticancer activity, and reduced toxicity toward normal fibroblasts ...
Abdellatif A. Helaly, Bandar A. Babgi, Yoji Kobayashi, Rohit K. Rai, Ehab M. M. Ali, Abdulaziz A. Kalantan, Walid M. I. Hassan, Mostafa A. Hussien, Muhammad M. I. Ismail   +8 more
wiley   +1 more source

P53 and anti‐p53 autoantibody complex versus anti‐p53 antibody as a biomarker for gastrointestinal cancer

Precision Medical Sciences, EarlyView.
This study compares the diagnostic value of the anti‐p53 autoantibody as potential biomarkers for gastrointestinal cancer with enzyme‐linked immunosorbent assay technique. Abstract Gastrointestinal tract cancer is among the most common types of cancer and includes colorectal cancer (CRC) and gastric cancer (GC).
V. Hamidi Sofiani, A. Ebrahimian Shiadeh, A. Tabarraei, H. Razavi Nikoo, F. Sadeghi, Gh. Kamrani, Y. Yahyapour, A. Moradi   +7 more
wiley   +1 more source

Expression of p27(Kip1), a Cyclin-Dependent Kinase Inhibitor, in Human Peripheral Blood Mononuclear Cells Is Inversely Associated with Potential Carcinogenic Risk in Obese Type 2 Diabetic Individuals Relative to Lean Normal Controls

, 2014
Isao Eto
openalex   +2 more sources

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review

Phytotherapy Research, EarlyView.
Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley   +1 more source

Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

, 2015
Raj N. Misra, Hai-yun Xiao, Kyoung S. Kim, Songfeng Lu, Wen-Ching Han, Stephanie A. Barbosa, John T. Hunt, David B. Rawlins, Weifang Shan, Syed Z. Ahmed, Ligang Qian, Bang-Chi Chen, Rui-Lin Zhao, Mark S. Bednarz, Kristen A. Kellar, Janet G. Mulheron, Roberta S. Batorsky, Urvashi V. Roongta, Amrita V. Kamath, Punit Marathe, Sunanda A. Ranadive, John S. Sack, John S. Tokarski, Nikola P. Pavletich, Francis Y. F. Lee, Kevin R. Webster, S. David Kimball   +26 more
openalex   +1 more source

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Phytotherapy Research, EarlyView.
ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal, Manjusha Pillai, Md. Shimul Bhuia, Muhammad Torequl Islam, Onkar Sharma, Rachna Verma, Eugenie Nepovimova, Kamil Kuca, Dinesh Kumar, Raihan Chowdhury   +9 more
wiley   +1 more source