Results 271 to 280 of about 152,744 (302)
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Regulation of mammalian cyclin-dependent kinase 2
1997Publisher Summary This chapter discusses the regulation of mammalian cyclin-dependent kinase 2. Progression through the cell cycle is ultimately governed by the cyclin-dependent kinases (CDKs). In mammalian cells, Cdk2 is the member of the CDK family responsible for catalyzing the transition from G1 to S phase.
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Medicinal Chemistry, 2007
Cyclin dependent kinases have emerged as important drug targets with a multitude of therapeutic potentials for their inhibitors. With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA study carried out on oxindole derivatives
Sanjeev Kumar Singh +2 more
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Cyclin dependent kinases have emerged as important drug targets with a multitude of therapeutic potentials for their inhibitors. With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA study carried out on oxindole derivatives
Sanjeev Kumar Singh +2 more
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Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors [PDF]
Bioorganic & Medicinal Chemistry Letters, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Li, Xiaoyuan +4 more
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Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2
Neuroscience Letters, 2014The expansion of a polyQ repeat within the ataxin-2 protein causes spinocerebellar ataxia type 2 (SCA2). However, neither the precise pathological mechanism nor the physiological functions of ataxin-2 are known. Ataxin-2 contains 47 (S/T)P sequences, which are targeted by proline-directed protein kinases such as the cyclin-dependent kinase 5 (Cdk5). We
Yoshihiro Kino +8 more
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European Journal of Medicinal Chemistry, 2006
Cyclin dependent kinases (CDKs) have appeared as an important drug targets over the years with diverse therapeutic potentials. With the objective of designing new chemical entities with enhanced inhibitory potencies against CDK 2 (CDK2) and CDK 4 (CDK4), the 3D-QSAR CoMFA study carried out on indenopyrazole derivatives as inhibitors of these kinases is
Nigus Dessalew +2 more
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Cyclin dependent kinases (CDKs) have appeared as an important drug targets over the years with diverse therapeutic potentials. With the objective of designing new chemical entities with enhanced inhibitory potencies against CDK 2 (CDK2) and CDK 4 (CDK4), the 3D-QSAR CoMFA study carried out on indenopyrazole derivatives as inhibitors of these kinases is
Nigus Dessalew +2 more
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Structural Basis for Interaction of Inhibitors with Cyclin-Dependent Kinase 2
Current Computer Aided-Drug Design, 2005Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Processo FAPESP: 01/07532-0 ; Processo FAPESP: 02/04383-7 ; Processo FAPESP: 04/00217-0 ; Cell cycle progression is tightly controlled by the ...
Canduri, Fernanda +1 more
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Cyclin-dependent Kinase 2 (CDK-2) Expression in Nonmelanocytic Human Cutaneous Lesions
Applied Immunohistochemistry & Molecular Morphology, 2010Lesions originating from different types of skin cells differ significantly with respect to their pathologic importance. The aim of this work was to examine as to what extent the differences in the origin are reflected in expression levels of CDK-2 and to investigate whether CDK-2 expression might be considered as potential marker useful for ...
Łukasz Kuźbicki +3 more
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Purification and reconstitution of cyclin-dependent kinase 2 in four states of activity
1997Publisher Summary This chapter discusses the purification and reconstitution of cyclin-dependent kinase 2 in four states of activity. The eukaryotic cell cycle is coordinated by several closely related serine/ threonine protein kinases, each consisting of a catalytic cyclin-dependent kinase (CDK) subunit and a regulatory cyclin subunit. The catalytic
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Immunohistochemical expression of cyclin-dependent kinase-2 in psoriasis
British Journal of Dermatology, 2009A. Bullon +5 more
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Trends in kinase drug discovery: targets, indications and inhibitor design
Nature Reviews Drug Discovery, 2021Helgi B Schiöth +2 more
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