Results 21 to 30 of about 361,160 (377)

Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. [PDF]

J Biol Chem, 2020
Recent clinical investigations indicate that anthracycline-based chemotherapies induce early decline in heart mass in cancer patients. Heart mass decline may be caused by a decrease in cardiac cell number because of increased cell death or by a reduction
Xia P, Chen J, Liu Y, Fletcher M, Jensen BC, Cheng Z.   +5 more
europepmc   +2 more sources

Identification of High-Affinity Inhibitors of Cyclin-Dependent Kinase 2 Towards Anticancer Therapy. [PDF]

Molecules, 2019
Cyclin-dependent kinase 2 (CDK2) is an essential protein kinase involved in the cell cycle regulation. The abnormal activity of CDK2 is associated with cancer progression and metastasis.
Mohammad T, Batra S, Dahiya R, Baig MH, Rather IA, Dong JJ, Hassan I.   +6 more
europepmc   +2 more sources

Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method

Journal of Cheminformatics, 2011
Background The reliable and robust estimation of ligand binding affinity continues to be a challenge in drug design. Many current methods rely on molecular mechanics (MM) calculations which do not fully explain complex molecular interactions.
Mazanetz Michael P, Ichihara Osamu, Law Richard J, Whittaker Mark   +3 more
doaj   +2 more sources

Specific Phosphorylation of Nucleophosmin on Thr199 by Cyclin- dependent Kinase 2-Cyclin E and Its Role in Centrosome Duplication [PDF]

Journal of Biological Chemistry, 2001
The kinase activity of cyclin-dependent kinase 2 (CDK2)-cyclin E is required for centrosomes to initiate duplication. We have recently found that nucleophosmin (NPM/B23), a phosphoprotein primarily found in nucleolus, associates with unduplicated ...
Yukari Tokuyama, Henning F. Horn, Kenji Kawamura, Pheruza Tarapore, Kenji Fukasawa   +4 more
openalex   +2 more sources

Caspase 3-mediated Cleavage of p21 Associated with the Cyclin A-Cyclin-dependent Kinase 2 Complex Is a Prerequisite for Apoptosis in SK-HEP-1 Cells [PDF]

Journal of Biological Chemistry, 2000
Apoptosis of SK-HEP-1 human hepatoma cells induced by treatment with ginsenoside Rh2 (G-Rh2) is associated with rapid and selective activation of cyclin A-associated cyclin-dependent kinase 2 (Cdk2).
Ying Jin, Kye Jin Yoo, You Hui Lee, Seung Ki Lee   +3 more
openalex   +2 more sources

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance The two E-type cyclins E1 and E2 are known to interact with Cdk2 and are thought to trigger cell cycle activity in carcinogenesis. However, the individual contributions of cyclin E1, cyclin E2, and Cdk2 for initiation and progression of ...
Sonntag R, Giebeler N, Nevzorova YA, Bangen JM, Fahrenkamp D, Lambertz D, Haas U, Hu W, Gassler N, Cubero FJ, Müller-Newen G, Abdallah AT, Weiskirchen R, Ticconi F, Costa IG, Barbacid M, Trautwein C, Liedtke C.   +17 more
europepmc   +2 more sources

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

Identification of selective cyclin-dependent kinase 2 inhibitor from the library of pyrrolone-fused benzosuberene compounds: an in silico exploration

Journal of Biomolecular Structure and Dynamics, 2021
The over-expression of cyclin-dependent kinase 2 is related to multiple cancers, which has led them to be a widely researched topic for nearly two decades.
Rahul Singh, Vijay Kumar Bhardwaj, Jatin Sharma, P. Das, Rituraj Purohit   +4 more
semanticscholar   +1 more source

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition. [PDF]

Clin Cancer Res, 2017
Au-Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.   +14 more
europepmc   +2 more sources

ASSOCIATION OF RS2069502 CYCLIN-DEPENDENT KINASE 4 GENE WITH BREAST CANCER [PDF]

Euromediterranean Biomedical Journal, 2020
The goal of this project was to evaluate the association of candidate genetic variant rs2069502 of the CDK4 gene with breast cancer and the effect of variant genotypes on the serum concentration of CDK4 enzyme and consequently, on the occurrence of ...
Dalya Shakir Al-owaidi
doaj   +1 more source