Results 31 to 40 of about 361,160 (377)

A novel binding pocket of cyclin‐dependent kinase 2 [PDF]

Proteins: Structure, Function, and Bioinformatics, 2008
AbstractThe cyclin‐dependent kinase 2 (cdk2) is a serine/threonine protein kinase that plays a key role in the cell cycle control system of all eukaryotic organisms. It has been a much studied drug target for potential anticancer therapy. Most cdk2 inhibitors in clinical development target almost exclusively the catalytic ATP‐binding pocket of cdk2 ...
Fatah Kashanchi, Chen Zeng, Hao Chen, Rachel Van Duyne, Naigong Zhang   +4 more
openaire   +3 more sources

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

PLoS ONE, 2023
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in ...
Anna McGriff, William J Placzek
doaj   +1 more source

Study of cytostatic and cytotoxic characteristics of modified peptide CDK4/6 inhibitors – functional analogs of p16INK4a (90-97)

Успехи молекулярной онкологии, 2021
Background. Application of mathematical modeling for search for biologically active molecules is currently a promising scientific approach. Application of numerical algorithms for optimization of peptide sequences and molecular dynamics allowed to obtain
V. K. Bozhenko, T. M. Kulinich, E. A. Kudinova, A. V. Ivanov, A. M. Shishkin, V. A. Solodkiy   +5 more
doaj   +1 more source

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression. [PDF]

Oncotarget, 2015
CCNE1 gene amplification is present in 15-20% ovary tumor specimens. Here, we showed that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell lines.
Yang L, Fang D, Chen H, Lu Y, Dong Z, Ding HF, Jing Q, Su SB, Huang S.   +8 more
europepmc   +2 more sources

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Journal of Translational Medicine, 2021
Background Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu   +6 more
doaj   +1 more source

CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors

Biomolecules, 2022
In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro, Mathias Fagbemi, Michael Tellier, Justyna Zaborowska, Stephanie Barker, Marjorie Fournier, Shona Murphy   +6 more
doaj   +1 more source

Investigation of the effect of 5-Aza-2'-deoxycytidine in comparison to and in combination with trichostatin a on p16INK4a, p14ARF, p15INK4b gene expression, cell growth inhibition and apoptosis induction in colon cancer Caco-2 cell line

International Journal of Preventive Medicine, 2021
Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei, Fraidoon Kavoosi, Vahid Ghasemzadeh   +2 more
doaj   +1 more source

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific Reports, 2023
p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina   +8 more
doaj   +1 more source

Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer [PDF]

, 2014
BACKGROUND: Lung cancer is one of the leading causes of cancer death worldwide. Even with complete resection, the prognosis of early-stage non-small cell lung cancer is poor due to local and distant recurrence, and it remains unclear which biomarkers are
Hideki Ishihara, Hiroshi Kubo, Kazuya Uchino, Masahiro Yoshimura, Sachiyo Tada, Satoshi Suzuki, Takashi Kondo, Takashi Suzuki, Tomoko Matsushima   +8 more
core   +1 more source

Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1

Scientific Reports, 2021
S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu, Xiao-Jing Li, Moges Dessale Asmamaw, Xiaa-Jing Shi, Hong-Min Liu   +4 more
doaj   +1 more source