Results 31 to 40 of about 161,781 (188)

Wound Healing Potential of Spirulina Protein on CCD-986sk Cells

Marine Drugs, 2019
Wound healing is a dynamic and complex process. The proliferation and migration of dermal fibroblasts are crucial for wound healing. Recent studies have indicated that the extracts from Spirulina platensis have a positive potential for wound healing ...
Ping Liu, Jeong-Wook Choi, Min-Kyeong Lee, Youn-Hee Choi, Taek-Jeong Nam   +4 more
doaj   +1 more source

Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

Cell Death and Disease, 2023
Esophageal squamous cell carcinoma (ESCC) is an upper gastrointestinal cancer with high morbidity and mortality. New strategies are urgently needed to prolong patients’ survival.
Xinning Liu, Yanan Jiang, Hao Zhou, Xiaokun Zhao, Mingzhu Li, Zhuo Bao, Zitong Wang, Chenyang Zhang, Zhenliang Xie, Jimin Zhao, Zigang Dong, Kangdong Liu, Zhiping Guo   +12 more
doaj   +1 more source

Oxidative Stress-Induced Unscheduled CDK1–Cyclin B1 Activity Impairs ER–Mitochondria-Mediated Bioenergetic Metabolism

Cells, 2021
Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation,
Jan-Gowth Chang, Ni Tien, Yi-Chih Chang, Meng-Liang Lin, Shih-Shun Chen   +4 more
doaj   +1 more source

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Cell Reports, 2019
Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat ...
Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart   +18 more
doaj   +1 more source

Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury [PDF]

Journal of Molecular and Cellular Cardiology, 2008
Ischemia/reperfusion (I/R) injury to the heart is accompanied by the upregulation and posttranslational modification of a number of proteins normally involved in regulating cell cycle progression. Two such proteins, cyclin-dependent kinase-2 (Cdk2) and its downstream target, the retinoblastoma gene product (Rb), also play a critical role in the control
Liem, David A, Zhao, Peng, Angelis, Ekaterini, Chan, Shing S, Zhang, Jun, Wang, Guangwu, Berthet, Cyril, Kaldis, Philipp, Ping, Peipei, MacLellan, W Robb   +9 more
openaire   +4 more sources

CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]

PLoS ONE, 2011
C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu, Lifeng Liu, Xueshan Qiu, Lili Jiang, Bo Huang, Haiying Li, Zixuan Li, Wenting Luo, Enhua Wang   +8 more
doaj   +1 more source

A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation

Бюллетень сибирской медицины, 2018
Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management.
E. V. Shakhristova, E. A. Stepovaya, O. L. Nosareva, L. S. Litvinova, D. A. Skuratovskaya, E. V. Rudikov, A. A. Sadykova, V. V. Novitsky   +7 more
doaj   +1 more source

Cervical Liposarcoma Revisited: A Case Report and Scoping Literature Review

Case Reports in Oncology, 2022
The commonest sites for liposarcoma are the retroperitoneum and lower extremities. Liposarcoma of the head and neck region is a rare and potentially life-threatening malignancy.
Takahiro Suzuki, Naoya Noguchi, Shion Shirane, Nanako Ansai, Teruyuki Sato, Kazue Ise, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Nobuo Ohta   +9 more
doaj   +1 more source

Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores

Scientific Reports, 2021
Thyroid hormone (TH) and thyroid hormone receptor (THR) regulate stem cell proliferation and differentiation during development, as well as during tissue renewal and repair in the adult.
Yan-Yun Liu, Jingjing Jiang, Sujie Ke, Anna Milanesi, Kiyomi Abe, Gilberto Gastelum, Jianrong Li, Gregory A. Brent   +7 more
doaj   +1 more source

Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation

Journal of Lipid Research, 2006
Docosahexaenoic acid (DHA), a PUFA of the n-3 family, inhibited the growth of FM3A mouse mammary cancer cells by arresting their progression from the late-G1 to the S phase of the cell cycle.
Naim A. Khan, Kazuhiro Nishimura, Virginie Aires, Tomoko Yamashita, David Oaxaca-Castillo, Keiko Kashiwagi, Kazuei Igarashi   +6 more
doaj   +1 more source