Results 31 to 40 of about 684,735 (325)
Toxicology Reports, 2015 Cell cycle deregulation is common in human hepatocellular carcinoma (HCC). To ensure proper cell cycle controlling, cyclin/cyclin-dependent kinases (CDK) complexes are tightly regulated by CDK inhibitors (CKIs) in normal cells.
Yu-Ting Peng +9 more
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Break CDK2/Cyclin E1 interface allosterically with small peptides. [PDF]
PLoS ONE, 2014 Most inhibitors of Cyclin-dependent kinase 2 (CDK2) target its ATP-binding pocket. It is difficult, however, to use this pocket to design very specific inhibitors because this catalytic pocket is highly conserved in the protein family of CDKs.
Hao Chen +9 more
doaj +1 more source
Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors [PDF]
Indian Journal of Pharmaceutical Sciences, 2010 Cyclin-dependent kinases are most extensively studied targets for cancer chemotherapy since the tumor cells exhibit false checkpoints and can proliferate even if the genome is compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular proteins.
M P Suthar, M M Patel
openaire +3 more sources
Brazilian Journal of Medical and Biological Research, 2014 p15INK4B, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the p15INK4B gene in chronic myeloid leukemia (CML) cells enhances myeloid progenitor formation from common myeloid progenitors. Therefore,
D.Y. Xia +5 more
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Wound Healing Potential of Spirulina Protein on CCD-986sk Cells
Marine Drugs, 2019 Wound healing is a dynamic and complex process. The proliferation and migration of dermal fibroblasts are crucial for wound healing. Recent studies have indicated that the extracts from Spirulina platensis have a positive potential for wound healing ...
Ping Liu +4 more
doaj +1 more source
Cell Death and Disease, 2023 Esophageal squamous cell carcinoma (ESCC) is an upper gastrointestinal cancer with high morbidity and mortality. New strategies are urgently needed to prolong patients’ survival.
Xinning Liu +12 more
doaj +1 more source
Cells, 2021 Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation,
Jan-Gowth Chang +4 more
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Drug design of cyclin-dependent kinase 2 inhibitor for melanoma from traditional Chinese medicine. [PDF]
Biomed Res Int, 2014 Tang HC, Chen CY, Chen CY.
europepmc +3 more sources
CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]
PLoS ONE, 2011 C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu +8 more
doaj +1 more source
Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
J Biol Chem 285,(2), 2010, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway. A novel regulatory motif was thus generated, providing for the combinatorial control of each MAPK intermediate.
arxiv +1 more source