Results 41 to 50 of about 161,781 (188)

The Role of p27kip1 in the Aggressiveness of Papillary Thyroid Carcinoma: A Clinicopathological Analysis

مجلة كلية الطب
Background: Cell-cycle-regulating proteins, including cyclin-dependent kinase inhibitor 1B p27kip1, have been researched in different malignancies, including thyroid carcinoma, and their association with tumor aggressiveness and recurrence has been ...
Wafaa K. Ibrahim, khitam R. Al-khafaji
doaj   +1 more source

Modulation of β-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2 [PDF]

Journal of Biological Chemistry, 2004
beta-Catenin functions as a downstream component of the Wnt/Wingless signal transduction pathway, and inappropriate control of cytosolic beta-catenin is a crucial step in the genesis of several human cancers. Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in
Chun Shik, Park, Sung Il, Kim, Mi Su, Lee, Cho-Ya, Youn, Dae Joong, Kim, Eek-Hoon, Jho, Woo Keun, Song   +6 more
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Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. [PDF]

PLoS Genetics, 2016
E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division.
Junko Odajima, Siddharth Saini, Piotr Jung, Yasmine Ndassa-Colday, Scott Ficaro, Yan Geng, Eugenio Marco, Wojciech Michowski, Yaoyu E Wang, James A DeCaprio, Larisa Litovchick, Jarrod Marto, Piotr Sicinski   +12 more
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Direct Activation of Cyclin-Dependent Kinase 2 by Human Papillomavirus E7 [PDF]

Journal of Virology, 2003
ABSTRACT Addition of human papillomavirus (HPV) E7 CDK2/cyclin A or CDK2/cyclin E, purified from either insect cells or bacteria, dramatically upregulates histone H1 kinase activity. Activation is substrate specific, with a smaller effect noted for retinoblastoma protein (Rb). The CDK2 stimulatory activity is equivalent in high-risk (HPV type
Wanxia, He, Doug, Staples, Clark, Smith, Chris, Fisher   +3 more
openaire   +2 more sources

Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells. [PDF]

PLoS ONE, 2013
There were studies investigating the effects of broadband infrared radiation (IR) on cancer cell, while the influences of middle-infrared radiation (MIR) are still unknown.
Hsin-Yi Chang, Meng-Her Shih, Hsuan-Cheng Huang, Shang-Ru Tsai, Hsueh-Fen Juan, Si-Chen Lee   +5 more
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Genistein Inhibits Rat Aortic Smooth Muscle Cell Proliferation Through the Induction of p27kip1

Journal of Pharmacological Sciences, 2008
Diet is one of the most important factors that influence the risks for cardiovascular diseases. Genistein, an isoflavone found in soy, may benefit the cardiovascular system. Here, we investigated the effect of genistein on platelet-derived growth factor (
Ji-Yeon Yu, Jung-Jin Lee, Yong Lim, Tack-Joong Kim, Yong-Ri Jin, Yhun Y. Sheen, Yeo-Pyo Yun   +6 more
doaj   +1 more source

Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding [PDF]

Biochemical and Biophysical Research Communications, 2009
The cyclin-dependent kinase CDK2 is inactivated by phosphorylation on either of the two neighbouring residues Thr14 or Tyr15. The effect of phosphorylation on metal ion binding has been investigated with peptides incorporating residues 6-20 of CDK2. The stoichiometry of Ca(2+) binding increased from 1 in the un- and singly-phosphorylated peptides to 2 ...
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Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2

BMC Bioinformatics, 2007
Background The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure yet are mediated by only a few key residues.
Gu Jenny, Bourne Philip E
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Anticancer activity of Elsholtzia winitiana var. dongvanensis Phuong on gastric cancer cells: phytochemical profiling, cell proliferation inhibition, senescence induction, and cell cycle arrest

Beni-Suef University Journal of Basic and Applied Sciences
Background Elsholtzia, a genus within the Lamiaceae family, comprises 42 species predominantly distributed across East and Southeast Asia. Elsholtzia winitiana var. dongvanensis Phuong (EWD) is a subspecies of Elsholtzia winitiana endemic to the Dong Van–
Van Hung Hoang, Thi Thanh Huong Le, Phu Hung Nguyen, Duy Hung Nguyen, Quang Tan Luc, Thi Kieu Oanh Nguyen, Khac Hung Do   +6 more
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Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases [PDF]

Journal of Biological Chemistry, 2009
The regulation of metabolism and growth must be tightly coupled to guarantee the efficient use of energy and anabolic substrates throughout the cell cycle. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glycolysis.
YALÇIN, ABDULLAH, Chesney, Jason, Telang, Sucheta, Wattenberg, Binks, Siow, Deanna, Brock, Erin, Clem, Amy L., Nelson, Kristin, Lane, Andrew, Simmons, Alan, Clem, Brian F.   +10 more
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