Results 41 to 50 of about 684,735 (325)
A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation
Бюллетень сибирской медицины, 2018 Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management.
E. V. Shakhristova +7 more
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Cyclin-Dependent Kinase-2 in the Birth and Death of Cardiac Muscle Cells [PDF]
Circulation Research, 2001 The proliferative cell cycle in both vertebrates and much simpler organisms entails the transduction of mitogenic signals to cyclically expressed proteins known as cyclins and, hence, to their catalytically active targets, the cyclin-dependent protein kinases (cdks).1 2 In yeast, a single kinase, cdc28, suffices to partner with all of the cyclins ...
W. Robb MacLellan, Michael D. Schneider
openaire +3 more sources
Using the structural kinome to systematize kinase drug discovery [PDF]
arXiv, 2021 Kinase-targeted drug design is challenging. It requires designing inhibitors that can bind to specific kinases when all kinase catalytic domains share a common folding scaffold that binds ATP. Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
arxiv
Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores
Scientific Reports, 2021 Thyroid hormone (TH) and thyroid hormone receptor (THR) regulate stem cell proliferation and differentiation during development, as well as during tissue renewal and repair in the adult.
Yan-Yun Liu +7 more
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Acta Pharmaceutica Sinica B, 2022 Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this ...
Sha-Sha Cheng +12 more
doaj
Cervical Liposarcoma Revisited: A Case Report and Scoping Literature Review
Case Reports in Oncology, 2022 The commonest sites for liposarcoma are the retroperitoneum and lower extremities. Liposarcoma of the head and neck region is a rare and potentially life-threatening malignancy.
Takahiro Suzuki +9 more
doaj +1 more source
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008 Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv +1 more source
Direct Activation of Cyclin-Dependent Kinase 2 by Human Papillomavirus E7 [PDF]
Journal of Virology, 2003 ABSTRACT Addition of human papillomavirus (HPV) E7 CDK2/cyclin A or CDK2/cyclin E, purified from either insect cells or bacteria, dramatically upregulates histone H1 kinase activity. Activation is substrate specific, with a smaller effect noted for retinoblastoma protein (Rb). The CDK2 stimulatory activity is equivalent in high-risk (HPV type
Chris Fisher +3 more
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Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. [PDF]
PLoS Genetics, 2016 E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division.
Junko Odajima +12 more
doaj +1 more source
Prediction of kinase inhibitor response using activity profiling, in-vitro screening, and elastic net regression [PDF]
BMC Systems Biology 2014, 8:74, 2013 Many kinase inhibitors have been approved as cancer therapies. Recently, libraries of kinase inhibitors have been extensively profiled, thus providing a map of the strength of action of each compound on a large number of its targets. These profiled libraries define drug-kinase networks that can predict the effectiveness of new untested drugs and ...
arxiv +1 more source