Results 51 to 60 of about 361,160 (377)

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]

, 2014
Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick, Andrew D. McAinsh, Christopher A. Smith, Clute, Collin, Daniel W. Gerlich, Daum, Dick, D’Angiolella, Gavet, Hagting, He, Higuchi, Hümmer, Joglekar, Kabeche, Lara-Gonzalez, Laurent Sansregret, Mark Petronczki, María Dolores Vázquez-Novelle, Mirchenko, Morin, Nasmyth, Nezi, Oliveira, Palframan, Parry, Peters, Rattani, Santaguida, Stemmann, Stevens, Vázquez-Novelle, Vázquez-Novelle, Wolf, Yamaguchi, Zhai   +36 more
core   +1 more source

Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.

Current Drug Targets, 2019
BACKGROUND Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-cycle progression. The elucidation of the CDK2 structure paved the way to investigate the molecular basis for inhibition of this enzyme, with the coordinated efforts
Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, A. A. Souto, W. F. de Azevedo   +3 more
semanticscholar   +1 more source

Экономические перспективы повышения уровня использования попутного нефтяного газа [PDF]

, 2004
A novel method employing filter arrays of a cDNA expression library for the identification of substrates for protein kinases was developed. With this technique, we identified a new member of the cyclin family, cyclin L2, as a substrate of the nuclear ...
Becker, Walter, Buessow, Konrad, de Graaf, Katrin, Hekerman, Paul, Herrmann, Andreas, Mueller-Newen, Gerhard, Packman, Len C., Spelten, Oliver   +7 more
core   +1 more source

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells [PDF]

Journal of Biological Chemistry, 2008
The human pregnane X receptor (hPXR) regulates the expression of critical drug metabolism enzymes. One of such enzymes, cytochrome P450 3A4 (CYP3A4), plays critical roles in drug metabolism in hepatocytes that are either quiescent or passing through the ...
Wenwei Lin, Jing Wu, Hanqing Dong, David C. Bouck, Fu-Yue Zeng, Taosheng Chen   +5 more
openalex   +2 more sources

CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]

PLoS ONE, 2011
C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu, Lifeng Liu, Xueshan Qiu, Lili Jiang, Bo Huang, Haiying Li, Zixuan Li, Wenting Luo, Enhua Wang   +8 more
doaj   +1 more source

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]

, 2016
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng, Hornicek, Francis J, Kan, Quancheng, Shen, Jacson K, Zhou, Yubing   +4 more
core   +1 more source

S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. [PDF]

, 2017
Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD.
Chao, Che-Yi, Chiang, En-Pei Isabel, Chiu, Shao-Chih, Rodriguez, Raymond L, Syu, Jia-Ning, Tang, Feng-Yao, Tsai, Shu-Yao, Yang, Mei-Due   +7 more
core   +1 more source

Cyclin-Dependent Kinase-2 in the Birth and Death of Cardiac Muscle Cells [PDF]

Circulation Research, 2001
The proliferative cell cycle in both vertebrates and much simpler organisms entails the transduction of mitogenic signals to cyclically expressed proteins known as cyclins and, hence, to their catalytically active targets, the cyclin-dependent protein kinases (cdks).1 2 In yeast, a single kinase, cdc28, suffices to partner with all of the cyclins ...
W. Robb MacLellan, Michael D. Schneider
openaire   +3 more sources

Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors

Journal of Chemical Information and Modeling, 2019
The hit-to-lead and lead optimization processes usually involve the design, synthesis, and profiling of thousands of analogs prior to clinical candidate nomination.
Kyle D. Konze, P. H. Bos, Markus K. Dahlgren, K. Leswing, Ivan Tubert Brohman, A. Bortolato, B. Robbason, Robert Abel, Sathesh Bhat   +8 more
semanticscholar   +1 more source

A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation

Бюллетень сибирской медицины, 2018
Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management.
E. V. Shakhristova, E. A. Stepovaya, O. L. Nosareva, L. S. Litvinova, D. A. Skuratovskaya, E. V. Rudikov, A. A. Sadykova, V. V. Novitsky   +7 more
doaj   +1 more source