Results 61 to 70 of about 161,781 (188)

Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors

Indian Journal of Pharmaceutical Sciences, 2010
Cyclin-dependent kinases are most extensively studied targets for cancer chemotherapy since the tumor cells exhibit false checkpoints and can proliferate even if the genome is compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular proteins.
Suthar, M. P., Patel, M. M.
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The impact of cyclin-dependent kinases 4 and 6 inhibitors in the immune response to mRNA SARS-CoV-2 vaccine in women with breast cancer. [PDF]

, 2022
Cristina Saavedra, Alejandro Vallejo, Federico Longo, J.J. Serrano Domingo, María Fernández-Abad, María Gión, Elena López-Miranda, Noelia Martínez-Jáñez, Eva Guerra, Jesús Chamorro, Diana Isabel Rosero, Héctor Velasco, Adrián Martín, Alfredo Carrato, José L. Casado, Alfonso Cortés   +15 more
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Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells

Molecules, 2017
Colorectal cancer is a leading cause of death worldwide and occurs through the highly complex coordination of multiple cellular pathways, resulting in carcinogenesis.
Sung-Suk Suh, Tai Kyoung Kim, Jung Eun Kim, Ju-Mi Hong, Trang Thu Thi Nguyen, Se Jong Han, Ui Joung Youn, Joung Han Yim, Il-Chan Kim   +8 more
doaj   +1 more source

Supplementary Figure 2 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity [PDF]

, 2023
Sally Trent, Chuanwei Yang, Cuiqi Li, Mary Lynch, Emmett V. Schmidt   +4 more
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Case report: a rare clinical presentation of a difficult diagnosis of dedifferentiated liposarcoma showing leiomyosarcoma phenotype in the ileocecal region

Frontiers in Oncology
Dedifferentiated liposarcoma is a malignant lipomatous tumor that rarely occurs in the gastrointestinal tract, including the ileocecal region. In this case, computed tomography and magnetic resonance imaging showed no fatty mass located in the mesenteric
Tomonori Kawasaki, Tomoaki Tashima, Kojiro Onohara, Yasumitsu Hirano, Misuzu Yamato, Suguru Shirotake, Tomoaki Torigoe, Yasuo Yazawa, Masataka Hirasaki, Masanori Wako, Taro Fujimaki, Jiro Ichikawa   +11 more
doaj   +1 more source

Ethanol Extract of Elaeagnus glabra f. oxyphylla Branches Alleviates the Inflammatory Response Through Suppression of Cyclin D3/Cyclin-Dependent Kinase 11^p58 Coupled to Lipopolysaccharide-Activated BV-2 Microglia

, 2022
Hye-Sun Lim, Eunjin Sohn, Yu Jin Kim, Bu‐Yeo Kim, Joo‐Hwan Kim, Soo‐Jin Jeong   +5 more
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Supplementary Materials and Methods, Figure Legends, Tables 1 - 2 from Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts [PDF]

, 2023
Sonya C. Tate, Shufen Cai, Rose T. Ajamie, Teresa Burke, Richard P. Beckmann, Edward M. Chan, Alfonso de Dios, Graham N. Wishart, Lawrence M. Gelbert, Damien M. Cronier   +9 more
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Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2 [PDF]

Bulletin of the Korean Chemical Society, 2007
Among several classes ofphenolic compounds, a group with the core structure of C6-C3-C6 is named flavonoids (benzo-γ-pyran derivatives),consisting of phenolic and pyran rings. According to theoxidation state of pyran ring, flavonoids can be furthersubdivided into five major subclasses as follows: flavonols,flavanols, flavones, isoflavones, and ...
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone

Journal of Diabetes Research, 2019
Metformin and pioglitazone are two commonly prescribed oral hypoglycemic agents for diabetes. Recent evidence suggests that these drugs may contribute to bladder cancer.
Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee   +13 more
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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation

Cell Division, 2012
Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle ...
Caillava Céline, Baron-Van Evercooren Anne   +1 more
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