Results 71 to 80 of about 361,160 (377)

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. [PDF]

PLoS Genetics, 2016
E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division.
Junko Odajima, Siddharth Saini, Piotr Jung, Yasmine Ndassa-Colday, Scott Ficaro, Yan Geng, Eugenio Marco, Wojciech Michowski, Yaoyu E Wang, James A DeCaprio, Larisa Litovchick, Jarrod Marto, Piotr Sicinski   +12 more
doaj   +1 more source

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]

, 2003
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A., Eppenberger, H. M., Magyar, J. P., Wagner, E., Weikert, C., Wightman, L.   +5 more
core   +1 more source

Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells. [PDF]

PLoS ONE, 2013
There were studies investigating the effects of broadband infrared radiation (IR) on cancer cell, while the influences of middle-infrared radiation (MIR) are still unknown.
Hsin-Yi Chang, Meng-Her Shih, Hsuan-Cheng Huang, Shang-Ru Tsai, Hsueh-Fen Juan, Si-Chen Lee   +5 more
doaj   +1 more source

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance [PDF]

, 2015
Seliciclib (R-Roscovitine) was identified as an inhibitor of CDKs and has undergone drug development and clinical testing as an anticancer agent. In this review, the authors describe the discovery of Seliciclib and give a brief summary of the biology of ...
Cavicchi, Laura, Khalil, Hilal S., Mitev, Vanio, Vlaykova, Tatyana, Zhelev, Nikolai   +4 more
core   +4 more sources

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Berberich, Nina, Fürst, Robert, Joore, Jos, Khandoga, Alexander G., Krombach, Fritz, Mayer, Bettina A., Sass, Gabriele, Schmerwitz, Ulrike K., Tiegs, Gisa, Totzke, Frank, Vollmar, Angelika M., Zahler, Stefan   +11 more
core   +1 more source

Cyclin dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway

Oncogene, 2015
Cyclin-dependent kinase 2 (CDK2) is a known regulator in the cell cycle control of the G1/S and S/G2 transitions. However, the role of CDK2 in tumorigenesis is controversial.
C. Peng, W. Zeng, Juan Su, Y. Kuang, Yijing He, Shuang Zhao, Jianglin Zhang, Weiya Ma, A. Bode, Z. Dong, Xiang Chen   +10 more
semanticscholar   +1 more source

Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2

BMC Bioinformatics, 2007
Background The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure yet are mediated by only a few key residues.
Gu Jenny, Bourne Philip E
doaj   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Best, A.K., Columbus, L., Dunn, C.A., Isakson, B.E., Johnstone, S.R., Koval, M., Kroncke, B.M., Lampe, P.D., Lo, C.W., Mitchell, L.A., Nakamoto, R.K., Peskova, Y., Straub, A.C.   +12 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source