Results 71 to 80 of about 161,781 (188)

Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2). [PDF]

ACS Med Chem Lett, 2023
Zeng M, Grandner JM, Bryan MC, Verma V, Larouche-Gauthier R, Leclerc JP, Zhao L, Haghshenas P, Aubert-Nicol S, Yadav A, Ashley M, Chen JZ, Durk M, Samy KE, Nespi M, Levy E, Merrick K, Moffat JG, Murray J, Oh A, Orr C, Segal E, Sims J, Sneeringer C, Prangley M, Vartanian S, Magnuson S, Parr BT.   +27 more
europepmc   +1 more source

Supplementary Methods and Figure legends from Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

, 2023
George Au‐Yeung, Franziska Lang, Walid J. Azar, Thomas J. Mitchell, Kate E. Jarman, Kurt Lackovic, Diar Aziz, Carleen Cullinane, Richard B. Pearson, Linda Mileshkin, Danny Rischin, Alison M. Karst, Ronny Drapkin, Dariush Etemadmoghadam, David D.L. Bowtell   +14 more
openalex   +1 more source

Recent Development of CDK2 Inhibitors as Anticancer Drugs: An Update (2015–2023)

Pharmaceutical Fronts
Cyclin-dependent kinase 2 (CDK2) is a critical regulator of cell division and has emerged as a promising target for anticancer treatment. In this article, we summarize the structural features of CDK2 inhibitors and corresponding binding modes, in ...
Yumei Jin, Hao Lu, Hu Ge, Xuben Hou, Hao Fang   +4 more
doaj   +1 more source

Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method

Journal of Cheminformatics, 2011
Background The reliable and robust estimation of ligand binding affinity continues to be a challenge in drug design. Many current methods rely on molecular mechanics (MM) calculations which do not fully explain complex molecular interactions.
Mazanetz Michael P, Ichihara Osamu, Law Richard J, Whittaker Mark   +3 more
doaj   +1 more source

Corrigendum: Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors. [PDF]

Front Chem, 2022
Shawish I, Nafie MS, Barakat A, Aldalbahi A, Al-Rasheed HH, Ali M, Alshaer W, Al Zoubi M, Al Ayoubi S, De La Torre BG, Albericio F, El-Faham A.   +11 more
europepmc   +1 more source

Clitocybin A, a Novel Isoindolinone, From the Mushroom Clitocybe aurantiaca, Inhibits Cell Proliferation Through G1 Phase Arrest by Regulating the PI3K/Akt Cascade in Vascular Smooth Muscle Cells

Journal of Pharmacological Sciences, 2012
Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an essential role in the pathogenesis of vascular diseases, such as atherosclerosis, hypertension, and restenosis.
Kyu-Dong Yoo, Eun-Seok Park, Yong Lim, Shin-Il Kang, Su-Hyang Yoo, Ha-Hee Won, Young-Hee Kim, Ick-Dong Yoo, Hwan-Soo Yoo, Jin Tae Hong, Yeo-Pyo Yun   +10 more
doaj   +1 more source

The Association between Cyclin Dependent Kinase 2 Associated Protein 1 (CDK2AP1) and Molecular Subtypes of Lethal Prostate Cancer. [PDF]

Int J Mol Sci, 2022
Gamallat Y, Bakker A, Khosh Kish E, Choudhry M, Walker S, Aldakheel S, Seyedi S, Huang KC, Ghosh S, Gotto G, Bismar TA.   +10 more
europepmc   +1 more source

Vaccinia virus regulates expression of p21WAF1/Cip1 in A431 cells

Memorias do Instituto Oswaldo Cruz, 2010
In this paper, we provide evidence that both the mRNA and protein levels of the cyclin-dependent kinase (CDK) inhibitor p21WAF1/CDK-interacting protein 1 (Cip1) increase upon infection of A431 cells with Vaccinia virus (VACV).
Anderson A Andrade, Bruno SAF Brasil, Anna CTC Pereira, Paulo CP Ferreira, Erna G Kroon, Cláudio A Bonjardim   +5 more
doaj   +1 more source

Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. [PDF]

J Med Chem, 2023
Faber EB, Wang N, John K, Sun L, Wong HL, Burban D, Francis R, Tian D, Hong KH, Yang A, Wang L, Elsaid M, Khalid H, Levinson NM, Schönbrunn E, Hawkinson JE, Georg GI.   +16 more
europepmc   +1 more source

Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors. [PDF]

Front Chem, 2022
Shawish I, Nafie MS, Barakat A, Aldalbahi A, Al-Rasheed HH, Ali M, Alshaer W, Al Zoubi M, Al Ayoubi S, De la Torre BG, Albericio F, El-Faham A.   +11 more
europepmc   +1 more source