Results 101 to 110 of about 338,209 (343)
The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation*
Journal of Biological Chemistry, 2006 Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including Alzheimer disease.
F. Plattner, Marco Angelo, P. Giese
semanticscholar +1 more source
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C [PDF]
European Journal of Pharmacology, 2008 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed protein serine/threonine kinase essential for brain development and implicated in synaptic plasticity, dopaminergic neurotransmission, drug addiction, and neurodegenerative disorders. Relatively little is known about the molecular mechanisms that regulate the activity of Cdk5 in vivo.
Bogachan, Sahin +4 more
openaire +2 more sources
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. [PDF]
PLoS ONE, 2015 Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases.
Bo S Kim +9 more
doaj +1 more source
Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival [PDF]
The Journal of Neuroscience, 2001 Cyclin-dependent kinase 5 (Cdk5) null mice exhibit a unique phenotype characterized by perinatal mortality, disrupted cerebral cortical layering attributable to abnormal neuronal migration, lack of cerebellar foliation, and chromatolytic changes of neurons in the brainstem and the spinal cord.
T, Tanaka +9 more
openaire +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
The Turkish Journal of Pediatrics, 2015 Cyclin-dependent kinase-like 5 gene-related epileptic encephalopathy is gradually becoming better known in child neurology practice. The related gene mutations cause early infantile epileptic encephalopathy characterized by intractable epilepsy ...
Sarenur Gökben +4 more
doaj
Frontiers in Cellular Neuroscience, 2018 p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease.
Eriko Kamiki +5 more
doaj +1 more source
Journal of Biological Chemistry, 1998 Cyclin-dependent kinase 5 (Cdk5) was originally isolated by its close homology to the human CDC2gene, which is a key regulator of cell cycle progression. However, unlike other Cdks, the activity of Cdk5 is required in post-mitotic neurons.
G. Patrick +4 more
semanticscholar +1 more source
Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis [PDF]
Journal of Biological Chemistry, 2010 Angiogenesis contributes to various pathological conditions. Due to the resistance against existing antiangiogenic therapy, an urgent need exists to understand the molecular basis of vessel growth and to identify new targets for antiangiogenic therapy.
Johanna, Liebl +6 more
openaire +2 more sources