Results 81 to 90 of about 185,382 (296)

6-Br-5methylindirubin-3′oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis [PDF]

, 2009
Indirubins known to target mammalian cyclin-dependent kinases (CDKs) and glycogen synthase kinase (GSK-3) were tested for their antileishmanial activity.
Smirlis, Despina, Soteriadou, Ketty, Myrianthopoulos, Vassilios, Meijer, Laurent, Prokopios, Magiatis, Grant, Karen, Mikros, Emmanuel, Xingi, Evangelia, Skaltsounis, Alexios-Leandros   +8 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator [PDF]

Journal of Biological Chemistry, 1995
Neuronal Cdc2-like kinase is a heterodimer of Cdk5 and a 25-kDa subunit that is derived from a 35-kDa brain- and neuron-specific protein called the neuronal Cdk5 activator (p35/p25nck5a) (Lew, J., Huang, Q.-Q., Qi, Z., Winkfein, R. J., Aebersold, R., Hunt, T., and Wang, J. H. (1994) Nature 371, 423-426; Tsai, L. H., Delalle, I., Caviness, V.
Tang, Damu, Yeung, Jeffrey T.F., Lee, Kiyoung, Matsushita, Masayuki, Matsui, Hideki, Tomizawa, Kazuhito, Hatase, Osamu, Wang, Jerry Hsueh-ching   +7 more
openaire   +3 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability

Frontiers in Cellular Neuroscience, 2018
p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease.
Eriko Kamiki, Eriko Kamiki, Roman Boehringer, Denis Polygalov, Toshio Ohshima, Thomas J. McHugh   +5 more
doaj   +1 more source

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway [PDF]

, 2012
Background Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes.
Hamelin, R., Hamelin Romain, Marc Moniatte, Amit Sharma, Chêne Arnaud, Doerig Christian, Lopez-Rubio, Jose-Juan, Dayer Guillem, Sharma, Amit, Dorin-Semblat Dominique, Dominique Dorin-Semblat, Doerig, C., Holland, Zoe M., Claes, Aurelie, Scherf, Artur, Guillem Dayer, Moniatte Marc, Sharma, A., Dayer, Guillem, Moniatte, Marc, Eeshita G Dastidar, Moniatte, M., Dorin-Semblat, Dominique, Chene, A., Dastidar, Eeshita, Claes Aurélie, Scherf, A., Aurelie Claes, Artur Scherf, Jose-Juan Lopez-Rubio, Lopez-Rubio Jose-Juan, Romain Hamelin, Claes, A., Sharma Amit, Dastidar Eeshita G, Zoe M Holland, Lopez-Rubio, J-J., Hamelin, Romain, Chene, Arnaud, Dayer, G., Scherf Artur, Dastidar, E.G., Doerig, Christian, Arnaud Chene, Dastidar, Eeshita G., Holland, Z.M., Dorin-Semblat, D., Holland Zoe M, Holland, Zoe, Christian Doerig   +49 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: The Wnt signaling pathway has essential functions in the central nervous system, where it regulates the major physiological functions of neurons, including development, differentiation, and plasticity.
Yang Shu, Min Xiang, Pei Zhang, Guangjian Qi, Feng He, Qian Zhang, Zheng Zhang, Zexi Lv, Xiang Peng, Hongwei Cai, Bo  Tian   +10 more
doaj   +1 more source

Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]

, 2005
Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core   +1 more source