Results 71 to 80 of about 185,382 (296)

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation [PDF]

, 2011
Background: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Jason Greenwald, Perozzo Remo, Greenwald Jason, Dirk Kostrewa, Leonardo Scapozza, Remo Perozzo, Kuettel Sabine, Perozzo, Remo, Shaheen Ahmed, Kostrewa Dirk, Scapozza Leonardo, Kuettel, Sabine, Greenwald, Jason, Scapozza, Leonardo, Ahmed Shaheen, Kostrewa, Dirk, Sabine Kuettel, Ahmed, Shaheen   +17 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cyclin-dependent kinase 5 activity regulates pain signaling [PDF]

Proceedings of the National Academy of Sciences, 2006
Several molecules and cellular pathways have been implicated in nociceptive signaling, but their precise molecular mechanisms have not been clearly defined. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system.
Tej K, Pareek, Jason, Keller, Sashi, Kesavapany, Harish C, Pant, Michael J, Iadarola, Roscoe O, Brady, Ashok B, Kulkarni   +6 more
openaire   +2 more sources

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cyclin‐dependent kinase 5 in synaptic plasticity, learning and memory [PDF]

Journal of Neurochemistry, 2006
AbstractCyclin‐dependent kinase 5 (Cdk5) is a serine/threonine kinase with a multitude of functions. Although Cdk5 is widely expressed, it has been studied most extensively in neurons. Since its initial characterization, the fundamental contribution of Cdk5 to an impressive range of neuronal processes has become clear.
Angelo, Marco, Plattner, Florian, Giese, K Peter   +2 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach

Frontiers in Aging Neuroscience, 2014
Alzheimer's disease (AD) is the most common cause of dementia worldwide. One of the main pathological changes that occurs in AD is the intracellular accumulation of hyperphosphorylated Tau protein in neurons.
John Fredy Castro-Alvarez, Sergio Alejandro Uribe Arias, Daniel eMejia Raigoza, Gloria Patricia eCardona Gomez   +3 more
doaj   +1 more source

Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival [PDF]

The Journal of Neuroscience, 2001
Cyclin-dependent kinase 5 (Cdk5) null mice exhibit a unique phenotype characterized by perinatal mortality, disrupted cerebral cortical layering attributable to abnormal neuronal migration, lack of cerebellar foliation, and chromatolytic changes of neurons in the brainstem and the spinal cord.
T, Tanaka, , Veeranna, T, Ohshima, P, Rajan, N D, Amin, A, Cho, T, Sreenath, H C, Pant, R O, Brady, A B, Kulkarni   +9 more
openaire   +2 more sources