Results 211 to 220 of about 165,369 (255)

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer.

Biosci Rep, 2019
Kapora E, Feng S, Liu W, Sakhautdinova I, Gao B, Tan W.   +5 more
europepmc   +1 more source

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Extraneuronal roles of cyclin‐dependent kinase 5

BioEssays, 2006
AbstractCyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the brain, where it regulates several neuronal activities, including cytoskeletal remodeling and synaptic transmission. While activity of Cdk5 has primarily been associated with neurons, there are now substantial data indicating that the kinase's activity and function ...
Jesusa L, Rosales, Ki-Young, Lee
openaire   +2 more sources

Acetylation of cyclin-dependent kinase 5 is mediated by GCN5

Biochemical and Biophysical Research Communications, 2014
Cyclin-dependent kinase 5 (CDK5), a member of atypical serine/threonine cyclin-dependent kinase family, plays a crucial role in pathophysiology of neurodegenerative disorders. Its kinase activity and substrate specificity are regulated by several independent pathways including binding with its activator, phosphorylation and S-nitrosylation.
Juhyung, Lee, Nuri, Yun, Chiho, Kim, Min-Young, Song, Kang-Sik, Park, Young J, Oh   +5 more
openaire   +2 more sources

The Activation and Inhibition of Cyclin-Dependent Kinase-5 by Phosphorylation

Biochemistry, 2007
Despite the very similar 3-dimensional structures as reflected by the more than 60% identity in amino acid sequences, CDK2 and CDK5 have very different functions and characteristics. Phosphorylation on a conserved Thr14 can inhibit activities of both the kinases, but phosphorylating another conserved Tyr15, however, can lead to totally opposite ...
Zhang, B., Tan, V.B.C., Lim, K.M., Tay, T.E.   +3 more
openaire   +2 more sources

Cyclin-dependent Kinase 5 and Neurodegenerative Diseases

Molecular Neurobiology
Neurodegenerative diseases are a group of diseases characterized by the progressive loss of neurons, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. These diseases have a high incidence and mortality rate globally, placing a heavy burden on patients and their families.
Mingxue Song, Yalong Qiang, Xiulan Zhao, Fuyong Song   +3 more
openaire   +2 more sources

Cyclin-dependent kinase-5 targeting for ischaemic stroke

Current Opinion in Pharmacology, 2009
Recovery from ischaemic stroke is dependent on survival of neurones, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels resulting in the re-formation of collateral circulation associated with enhanced neuronal survival and reduced morbidity and mortality.
Mark, Slevin, Jerzy, Krupinski
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Cyclin-Dependent Kinase 5--A Neuronal Killer?

Science of Aging Knowledge Environment, 2003
In dividing cells, cyclin-dependent kinases (Cdks) are cell cycle-associated protein kinases that regulate proliferation, differentiation, senescence, and apoptosis. In neurons that no longer divide, deregulation of Cdks, especially Cdk5, occurs in many neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD).
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A brain-specific activator of cyclin-dependent kinase 5

Nature, 1994
Phosphorylation of the neurofilament proteins of high and medium relative molecular mass, as well as of the Alzheimer's tau protein, is thought to be catalysed by a protein kinase with Cdc2-like substrate specificity. We have purified a novel Cdc2-like kinase from bovine brain capable of phosphorylating both the neurofilament proteins and tau.
Lew, J., Huang,Q Q., Qi, Robert Zhong, Winkfein, R.J., Aebersold, R., Hunt, T., Wang, J.H.   +6 more
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Cyclin Dependent Kinase 5 (Cdk5)

2008
Neuronsmigrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration.
Ip, Nancy Yuk-Yu LIFS, Tsai, Li-Huei
openaire   +2 more sources