Results 221 to 230 of about 165,369 (255)

Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration

NeuroReport, 2012
In addition to senile plaque and neurofibrillary tangles, granulovacuolar degeneration is a hallmark of Alzheimer's disease. A number of tau kinases, such as c-jun N-terminal kinase (JNK), glycogen-synthase kinase-3β (GSK3β), and casein kinase 1 (CK1), have been reported to be markers of granulovacuolar degeneration.
Masahiro, Nakamori, Tetsuya, Takahashi, Yuu, Yamazaki, Takashi, Kurashige, Takemori, Yamawaki, Masayasu, Matsumoto   +5 more
openaire   +2 more sources

Modulation of Reelin signaling by Cyclin-dependent kinase 5

Brain Research, 2007
The Reelin signaling and Cyclin-dependent kinase 5 (Cdk5) both regulate neuronal positioning in the developing brain. Using double-transgenic mice, we have previously shown that these two signaling pathways lie in parallel fashion and have a genetic interaction.
Toshio, Ohshima, Hiromi, Suzuki, Toshifumi, Morimura, Masaharu, Ogawa, Katsuhiko, Mikoshiba   +4 more
openaire   +2 more sources

The roles of cyclin‐dependent kinase 5 in dendrite and synapse development

Biotechnology Journal, 2007
AbstractSince the isolation of cyclin‐dependent kinase 5 (Cdk5), this proline‐directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Recently, a number of players implicated in dendrite and synapse development have been identified as Cdk5 substrates.
Ip, NY, Cheung, ZH
openaire   +4 more sources

Cyclin-dependent kinases 5 template: Useful for virtual screening

Computers in Biology and Medicine, 2012
The present study reports the development of a template for the active binding site of Cdk5 for structure-based drug design. The developed template of Cdk5 was validated by redocking with ligands I (PBD code 1UNG), II (PBD code 1UNL) and III (PBD code 1UNH).
Siripit Pitchuanchom, Chantana Boonyarat, Stefano Forli, Arthur J. Olson, Chavi Yenjai   +4 more
openaire   +2 more sources

Reelin and Cyclin-Dependent Kinase 5

2008
Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter,
openaire   +1 more source

Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration

2012
Injury to the central nervous system often leads to irreversible deficits because of the failure of damaged axons to regrow and restore the functional neural circuitry. Coordinated orchestration of multiple cellular processes including cytoskeletal dynamics and gene expression are essential for both developmental and regenerative axon growth. Recently,
Ye, Tao LIFS, Fu, Kit Yu, Ip, Nancy Y.
openaire   +3 more sources

Role of cyclin-dependent kinase 5 in capsaicin-induced cough

European Journal of Pharmacology, 2007
The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.
Junzo, Kamei, Shun-suke, Hayashi, Yoshiki, Takahashi, Chihiro, Nozaki   +3 more
openaire   +2 more sources

Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium

Neuroscience, 2005
Although numerous studies have demonstrated a neuroprotective and anti-apoptotic role of lithium in neuronal cell cultures, the precise mechanism by which this occurs, remains to be elucidated. In this study, we evaluated the lithium-mediated neuroprotection against colchicine-induced apoptosis in cultured cerebellar granule neurons. Previously, it has
E G, Jordà, E, Verdaguer, A M, Canudas, A, Jiménez, S, Garcia de Arriba, C, Allgaier, M, Pallàs, A, Camins   +7 more
openaire   +2 more sources

Cyclin-Dependent Kinase 5 and Insulin Secretion

2008
Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood.
Christina Bark, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, Per-Olof Berggren   +4 more
openaire   +1 more source

Cyclin-Dependent Kinase 5

2009
T. Ohshima, K. Mikoshiba
openaire   +1 more source