Results 291 to 300 of about 338,209 (343)

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Cell cycle follows ‘pause and play’ mechanism in salt and cold stress recovery in diverse plant species

New Phytologist, EarlyView.
Summary Changes to organismal growth induced by environmental stress are orchestrated at the cellular level. These periods of stress may be followed by recovery periods, when plants have the opportunity to return to normal growth conditions. However, the cell cycle mechanisms underlying recovery are poorly understood.
Olivia S. Hazelwood, Kamryn A. Diehl, Vicky Hollenbeck, Joh Demura‐Devore, Dustin Herb, Joseph P. Gallagher, M. Arif Ashraf   +6 more
wiley   +1 more source

MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer.

Biosci Rep, 2019
Kapora E, Feng S, Liu W, Sakhautdinova I, Gao B, Tan W.   +5 more
europepmc   +1 more source

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A brain-specific activator of cyclin-dependent kinase 5

Nature, 1994
Phosphorylation of the neurofilament proteins of high and medium relative molecular mass, as well as of the Alzheimer's tau protein, is thought to be catalysed by a protein kinase with Cdc2-like substrate specificity. We have purified a novel Cdc2-like kinase from bovine brain capable of phosphorylating both the neurofilament proteins and tau.
J. Lew, Qi-Quan Huang, Z. Qi, R. Winkfein, R. Aebersold, T. Hunt, Jerry H. Wang   +6 more
semanticscholar   +3 more sources

A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases.

International Journal of Biological Macromolecules, 2023
Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly found in the brain and plays a significant role in developing the central nervous system.
Shivani Batra, Shagufta Jahan, A. Ashraf, B. Alharby, Talha Jawaid, A. Islam, Imtaiyaz Hassan   +6 more
semanticscholar   +1 more source

Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5

Journal of Pineal Research, 2021
Melatonin helps to maintain circadian rhythm, exerts anticancer activity, and plays key roles in regulation of glucose homeostasis and energy metabolism.
Jinpeng Wu, Zengqi Tan, Hongjiao Li, Meixuan Lin, Yazhuo Jiang, Liang Liang, Qilong Ma, Junjie Gou, Lulu Ning, Xiang Li, F. Guan   +10 more
semanticscholar   +1 more source

Extraneuronal roles of cyclin‐dependent kinase 5

BioEssays, 2006
AbstractCyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the brain, where it regulates several neuronal activities, including cytoskeletal remodeling and synaptic transmission. While activity of Cdk5 has primarily been associated with neurons, there are now substantial data indicating that the kinase's activity and function ...
Jesusa L, Rosales, Ki-Young, Lee
openaire   +2 more sources

Cyclin-dependent kinase-5 targeting for ischaemic stroke

Current Opinion in Pharmacology, 2009
Recovery from ischaemic stroke is dependent on survival of neurones, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels resulting in the re-formation of collateral circulation associated with enhanced neuronal survival and reduced morbidity and mortality.
Mark, Slevin, Jerzy, Krupinski
openaire   +2 more sources

Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration

NeuroReport, 2012
In addition to senile plaque and neurofibrillary tangles, granulovacuolar degeneration is a hallmark of Alzheimer's disease. A number of tau kinases, such as c-jun N-terminal kinase (JNK), glycogen-synthase kinase-3β (GSK3β), and casein kinase 1 (CK1), have been reported to be markers of granulovacuolar degeneration.
Masahiro, Nakamori, Tetsuya, Takahashi, Yuu, Yamazaki, Takashi, Kurashige, Takemori, Yamawaki, Masayasu, Matsumoto   +5 more
openaire   +2 more sources

Cyclin Dependent Kinase 5 (Cdk5)

2008
Neuronsmigrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration.
Ip, Nancy Yuk-Yu LIFS, Tsai, Li-Huei
openaire   +2 more sources