Results 271 to 280 of about 185,382 (296)

Molecular model of cyclin-dependent kinase 5 complexed with roscovitine

Biochemical and Biophysical Research Communications, 2002
Here is described a structural model for the binary complex CDK5-roscovitine. Roscovitine has been shown to potently inhibit cyclin-dependent kinases 1, 2 and 5 (CDK1, 2, and 5), and the structure of CDK2 complexed with roscovitine has been reported; however, no structural data are available for complexes of CDK5 with inhibitors.
de Azevedo, W. F., Gaspar, R. T., Canduri, F., Camera, J. C., da Silveira, NJF   +4 more
openaire   +3 more sources

Cyclin-Dependent Kinase 5

2009
T. Ohshima, K. Mikoshiba
openaire   +1 more source

A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)

Expert Opinion on Therapeutic Patents, 2023
Markéta Kovalova, Václav Mik, Radek Jordá   +2 more
exaly  

Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy?

European Heart Journal, 1999
J M Li, Gavin Brooks
exaly  

Cyclin-Dependent Kinase Inhibitor P27Kip1 Is Required for Mouse Mammary Gland Morphogenesis and Function

Journal of Cell Biology, 2001
Rebecca S Muraoka, CARLOS L Arteaga, Arteaga CARLOS L   +2 more
exaly  

Cyclin-Dependent Kinase 5

2006
openaire   +1 more source

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

Bioorganic and Medicinal Chemistry Letters, 2004
Christopher J Helal, Michael K Ahlijanian, Frank S Menniti   +2 more
exaly  

Cyclin-Dependent Kinase 5

2018
openaire   +1 more source

The cyclin-dependent kinase inhibitor p21 is required for TGF-β1-induced podocyte apoptosis

Kidney International, 2005
Jeffrey W Pippin, Stuart J Shankland
exaly  

Cyclin-Dependent Kinase 5

2003
openaire   +1 more source